Key Points * R 41 Q and R 46 Q point mutations in PAR 1 in mice enabled studies of APC ’ s in vivo mechanism of action in lethal sepsis and ischemic stroke

Ranjeet K. Sinha,* Yaoming Wang,* Zhen Zhao, Xiao Xu, Laurent Burnier, Naveen Gupta, José A. Fernández, Greg Martin, Sergey Kupriyanov, Laurent O. Mosnier, Berislav V. Zlokovic, and John H. Griffin The Scripps Research Institute, La Jolla, CA; Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, Los Angeles, CA; Department of Medicine, University of California, San Diego, CA.