Fundamental studies comparing nanobubbles and microbubbles as vascular disrupting agents: Elucidating on the mechanism of action using photoacoustic imaging (Conference Presentation)

In this work, we examine the potential of photoacoustic imaging for understanding the biophysical mechanism of nanobubble and microbubble-based vascular disrupting therapies. We present for the first time, a direct in-vivo comparison between sub-micron nanobubbles and the commercially available microbubbles. Our results show that PA imaging of tumor oxygenation is capable of measuring the nanobubble-induced almost 40% cell death as a result of vascular disruption.