Downregulation of BCRP (ABCG2) in Placenta of Rat Model of Preeclampsia.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology（2022）
摘要
Our data demonstrates that the endotoxin PE rat model exhibits proteinuria and immune activation consistent with human disease. Importantly, our observations of decreased placenta expression of BCRP in this PE model is consistent with findings in humans. This indicates that this preclinical model may serve as a useful translational tool to examine the impact of PE on the disposition and fetal exposure of BCRP drug substrates.
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