High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk John I. Nurnberger , Yumin Wang , Yong Zang , Dongbing Lai , Leah Wetherill , Howard J. Edenberg , Fazil Aliev , Martin H. Plawecki , David Chorlian , Grace Chan , Kathleen Bucholz , Lance Bauer , Chella Kamarajan , Jessica E. Salvatore , Manav Kapoor , Victor Hesselbrock , Danielle Dick , Laura Bierut , Vivia McCutcheon , Jacquelyn L. Meyers , Bernice Porjesz , John Kramer , Samuel Kuperman , Sivan Kinreich , Andrey P. Anokhin , B. Porjesz , V. Hesselbrock , T. Foroud , A. Agrawal , D. Dick , V. Hesselbrock , H.J. Edenberg , T. Foroud , J. Nurnberger , Y. Liu , S. Kuperman , J. Kramer , B. Porjesz , J. Meyers , C. Kamarajan , A. Pandey , L. Bierut , J. Rice , K. Bucholz , A. Agrawal , M. Schuckit , J. Tischfield , A. Brooks , R. Hart , L. Almasy , D. Dick , J. Salvatore , A. Goate , M. Kapoor , P. Slesinger , D. Scott , L. Bauer , L. Wetherill , X. Xuei , D. Lai , S. O’Connor , M. Plawecki , Y. Zang , L. Acion , G. Chan , D.B. Chorlian , J. Zhang , S. Kinreich , G. Pandey , M. Chao , A. Anokhin , V. McCutcheon , S. Saccone , F. Aliev , P. Barr , H. Chin , A. Parsian Biological Psychiatry Global Open Science（2021）
摘要
Predictive power for PRSs in the extremes of the distribution suggests that these may have future clinical utility. Uncertainties in interpretation at the individual level still preclude current application.
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关键词
Alcohol use disorder, Clinical variables, Polygenic risk scores, Prediction of illness, Receiver operating characteristics curves, Survival analysis
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