Pharmacological Characterization of a Novel Neuroactive Steroid Prodrug, NTS-104, and Its Neuroprotective Activity in Experimental Stroke Models.

Li Zhang,Robin Schwartz-Byrne,Steven Gertz,Matthew McGuire,Colleen Woodhouse,Brianna Powell,Min Wei,Chao Li, Clare B Billing,Todd A Verdoorn, Leslie Lam,Tom J Parry,Benjamin Buller,Zheng Gang Zhang,David Poulsen,Michael Chopp

Stroke（2022）

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摘要

NTS-104 is a novel prodrug that converts to a novel neuroactive steroid, NTS-105, which improves functional outcomes in experimental ischemic stroke models.

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关键词

brain,cytokine,middle cerebral artery,plasma,prodrug

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