Prognostic and Predictive Value of Immune-Related Gene Expression Signatures vs Tumor-Infiltrating Lymphocytes in Early-Stage ERBB2/HER2-Positive Breast Cancer: A Correlative Analysis of the CALGB 40601 and PAMELA Trials.

Aranzazu Fernandez-Martinez,Tomás Pascual,Baljit Singh,Paolo Nuciforo,Naim U Rashid,Karla V Ballman,Jordan D Campbell,Katherine A Hoadley,Patricia A Spears,Laia Pare,Fara Brasó-Maristany,Nuria Chic,Ian Krop,Ann Partridge,Javier Cortés,Antonio Llombart-Cussac,Aleix Prat,Charles M Perou,Lisa A Carey

JAMA oncology（2023）

引用 6|浏览23

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摘要

Results of this study suggest that multiple B-cell-related signatures were more strongly associated with pCR and EFS than TILs, which largely represent T cells. When both TILs and gene expression are available, the prognostic value of immune-related signatures appears to be superior.

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