Liquid BIOpsy for MiNimal RESidual DiSease Detection in Head and Neck Squamous Cell Carcinoma (LIONESS) – A personalised analysis of circulating cell-free tumour DNA

Introduction Circulating cell-free tumour DNA (ctDNA) is an emerging biomarker but has not yet been studied sufficiently for head and neck squamous cell carcinoma (HNSCC). The detection of ctDNA as a marker of minimal residual disease following curative-intent treatment holds promise for identifying patients at an increased risk of relapse, who may benefit from adjuvant radio(chemo)therapy or facilitate close monitoring with repeat resection if needed.