The combined finding of HPV 16, 18, or 45 and cytologic Atypical Glandular Cells (AGC) indicates a greatly elevated risk of in situ and invasive cervical adenocarcinoma

Mark Schiffman,Lisa Mirabello,Didem Egemen,Brian Befano,Yanzi Xiao,Nicolas Wentzensen,Tina Raine-Bennett,Ritu Nayar,Li C. Cheung,Anne Rositch,Terri Beaty,Rebecca B. Perkins,Silvia de Sanjose,Thomas Lorey,Philip E. Castle,Robert D. Burk

Gynecologic Oncology（2023）

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摘要

•Cervical screening has not controlled cervical adenocarcinoma.•We looked for early markers of adenocarcinoma that might be useful for early detection of adenocarcinoma precursors.•The combination of HPV 16/18/45 and cytologic AGC predicts high risk of adenocarcinoma and adenocarcinoma in situ.

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关键词

Cervix,Screening,HPV,Adenocarcinoma,Cytology

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