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    • One-Pot Synthesis of Luminescent and Photothermal Carbon Boron-Nitride Quantum Dots Exhibiting Cell Damage Protective Effects

    Grazia M. L. Consoli,Ludovica Maugeri,Nicolo Musso,Antonino Gulino,Luisa D'Urso,Paolo Bonacci,Gianpiero Buscarino,Giuseppe Forte,Salvatore Petralia

    ADVANCED HEALTHCARE MATERIALS（2024）

    CNR Inst Biomol Chem | Univ Catania | Univ Palermo

    Cited 2|Views16
    Abstract
    Zero-dimensional boron nitride quantum dots (BNQDs) are arousing interest for their versatile optical, chemical, and biochemical properties. Introducing carbon contents in BNQDs nanostructures is a great challenge to modulate their physicochemical properties. Among the carbon moieties, phenolic groups have attracted attention for their biochemical properties and phenol-containing nanomaterials are showing great promise for biomedical applications. Herein, the first example of direct synthesis of water dispersible BNQDs exposing phenolic and carboxylic groups is presented. The carbon-BNQDs are prepared in a single-step by solvent-assisted reaction of urea with boronic reagents and are characterized by optical absorption, luminescence, Raman, Fourier transform infrared and NMR spectroscopy, X-ray photoelectron spectroscopy, dynamic light scattering, and atomic force microscopy. The carbon-BNQDs exhibit nanodimension, stability, high photothermal conversion efficiency, pH-responsive luminescence and Z-potential. The potential of the carbon-BNQDs to provide photothermal materials in solid by embedding in agarose substrate is successfully investigated. The carbon-BNQDs exhibit biocompatibility on colorectal adenocarcinoma cells (Caco-2) and protective effects from chemical and oxidative stress on Caco-2, osteosarcoma (MG-63), and microglial (HMC-3) cells. Amplicon mRNA-seq analyses for the expression of 56 genes involve in oxidative-stress and inflammation are performed to evaluate the molecular events responsible for the cell protective effects of the carbon-BNQDs. An innovative one-pot synthesis for the preparation of luminescent and photothermal carbon content boron nitride quantum dots (BNQDs), showing an efficiently cell damage protective effects driven by antioxidant and anti-inflammatory processes. image
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    Key words
    anti-inflammatory effect,antioxidant,luminescent boron nitride quantum-dots,nanomaterials,photothermal
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    【要点】：本文报道了一种创新的一锅合成法，制备出具有发光和光热性能的碳硼氮量子点，这些量子点对细胞损伤具有保护作用。
    

    【方法】：通过溶剂辅助反应，将尿素与硼酸试剂直接反应，合成了暴露酚羟基和羧基的水分散性碳硼氮量子点。
    

    【实验】：采用光学吸收、发光、拉曼、红外光谱、核磁共振、X射线光电子能谱、动态光散射和原子力显微镜对碳硼氮量子点进行了表征。实验使用的数据集名称未在文中明确提及，但文中指出对Caco-2、MG-63和HMC-3细胞进行了mRNA-seq分析，研究了56个与氧化应激和炎症相关的基因表达，以评估碳硼氮量子点对细胞保护作用的分子机制。结果显示，这些量子点具有良好的生物相容性，并能保护细胞免受化学和氧化压力的伤害。