The American University of Beirut (AUB) (Arabic: الجامعة الأميركية في بيروت) is a private, non-sectarian, and independent university chartered in New York with its campus in Beirut, Lebanon. AUB is governed by a private, autonomous board of trustees and offers programs leading to bachelor's, master's, MD, and PhD degrees.AUB has an operating budget of $423 million with an endowment of approximately $768 million. The campus is composed of 64 buildings, including the American University of Beirut Medical Center (AUBMC, formerly known as AUH – American University Hospital) (420 beds), four libraries, three museums and seven dormitories. Almost one-fifth of AUB's students attended secondary school or university outside Lebanon before coming to AUB. AUB graduates reside in more than 120 countries worldwide. The language of instruction is English. Degrees awarded at the university are officially registered with the New York Board of Regents.
To describe the ergonomic challenges inherent to otolaryngology–head and neck surgery and to synthesize current evidence on their impact on surgeon wellness, performance, and career sustainability. This narrative review integrates published literature addressing ergonomic risk factors across otolaryngology subspecialties, operative modalities, and clinical settings. Key themes include posture-related strain, visualization systems, operating room design, gender-based anthropometric mismatch, and mitigation strategies reported in observational studies, surveys, and ergonomic frameworks. The literature consistently demonstrates a high prevalence of work-related musculoskeletal disorders among otolaryngologists, most commonly affecting the neck, shoulders, and back. Ergonomic burden varies by subspecialty and surgical modality and is driven by sustained cervical flexion, static postures, asymmetric upper-limb loading, visual strain, and noise exposure. Female surgeons experience a disproportionate ergonomic burden related to mismatch between body dimensions and equipment design, resulting in added cognitive and workflow demands. These factors are associated with pain, reduced efficiency, burnout, and, in severe cases, early modification or cessation of operative practice. Ergonomic strain in otolaryngology is widespread, cumulative, and modifiable. Incorporating precision ergonomics, individualized operating room configuration, microbreaks, and early ergonomic education into surgical practice and training is essential to preserve surgeon health, optimize performance, and ensure long-term workforce sustainability.
This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA(2)LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), with the participation of 210 delegates from 107 national and international societies, from 59 countries. The consensus conference was held on December 6th, 2024. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease, defined by a rapid appearance of wheals, angioedema, or both. The lifetime prevalence of acute urticaria is estimated to be approximately 20%. Chronic urticaria, categorized as either chronic spontaneous urticaria or chronic inducible urticaria, is disabling, impairs quality of life, and affects performance at work and school, however, novel therapies are available. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert-guided and evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.
Paired box (PAX) genes encode a family of nine transcription factors that function as master regulators of embryogenesis, organogenesis, and lineage specification. Their tightly regulated spatial and temporal expression is essential for the development of multiple organ systems, including the central nervous system, eyes, kidneys, immune system, musculoskeletal system, and endocrine organs. Germline mutations of PAX genes result in a broad and often pleiotropic spectrum of human disease, reflecting the developmental programs governed by each family member. Pathogenic variants in PAX genes underlie diverse congenital disorders such as aniridia (PAX6), renal coloboma syndrome (PAX2), otofaciocervical syndrome with immunodeficiency (PAX1), Waardenburg syndrome (PAX3), maturity-onset diabetes of the young (PAX4), and tooth agenesis (PAX9). These conditions frequently demonstrate variable expressivity, incomplete penetrance, and overlapping phenotypes, which make it challenging to be clinically recognized. Beyond embryogenesis and embryologic development, emerging evidence indicates that several PAX proteins remain active in postnatal tissue maintenance, adult stem cell regulation, immune function, and regenerative responses (particularly PAX7 in skeletal muscle satellite cells and PAX5 in B-cell homeostasis), further expanding their clinical relevance. This review provides a synopsis of the major, clinically relevant, germline PAX gene mutations, emphasizing genotype–phenotype correlations, developmental mechanisms, and disease classification across the organ systems. By integrating molecular genetics with human pathology, we highlight the diagnostic implications of PAX genes as central determinants of congenital disease and provide a framework for understanding how alterations in the developmental transcriptional networks translate into human pathology.
Previous studies have demonstrated poor outcomes in pediatric patients with H3 G34-mutant diffuse hemispheric glioma (DHG). However, the biological basis for this therapeutic resistance remains poorly understood. Furthermore, the effectiveness of temozolomide (TMZ) and the role of surgery in pediatric patients remain uncertain. Therefore, we performed a multi-institutional retrospective analysis of the clinical, imaging, and molecular characteristics of 36 pediatric (≤ 18 years) patients with newly diagnosed H3 G34-mutant DHG. The median age of the cohort was 14 years (8–18 years). The median progression-free survival (PFS) was 0.7 years (95
BACKGROUND:Prostate cancer in the Middle East and North Africa (MENA) region is shaped by a complex interplay of behavioral and environmental risk factors, yet comprehensive estimates of preventable cases remain scarce. To address this gap, we estimated population-attributable fractions (PAFs) for a range of modifiable exposures among men aged 50 years and older and assessed potential reductions in incidence under feasible intervention scenarios. METHODS:Regional prevalence data were combined with relative risks from meta-analyses to compute closed-form PAFs for tobacco smoking, obesity, physical inactivity, high dairy and calcium intake, heavy alcohol use, drinking water nitrates, trihalomethanes, arsenic, lead, selenium status, ambient PM2.5 and NO2, and occupational diesel exhaust, covering an estimated 47 million men. Estimates were validated using a synthetic cohort simulation of 100,000 individuals, with uncertainty quantified through Monte Carlo sampling. RESULTS:Results showed that drinking water nitrate exposure accounted for the largest single fraction (17.4%), followed by tobacco smoking (9.5%), physical inactivity (6.7%), and trihalomethane exposure (5.0%), while other exposures contributed smaller but meaningful shares. Joint elimination of all exposures projected a 45.5% reduction in incidence, and simultaneous feasible reductions in four targeted exposures yielded a combined potential impact fraction of 12.1%. CONCLUSIONS:These findings suggest that integrated water quality management, tobacco control, lifestyle interventions, and targeted environmental surveillance should be prioritized to reduce prostate cancer burden in the MENA region. However, estimates of drinking-water nitrate exposure rely on limited evidence from a single case-control study with a relatively small sample size, and should therefore be considered exploratory and primarily hypothesis-generating.
