AMRI Hospitals is a private hospital chain which is headquartered in the city of Kolkata, West Bengal, India. The company's head office is in Kolkata, West Bengal, with 3 units in Kolkata (Dhakuria, Salt Lake and Mukundapur), 1 clinic in Kolkata (Southern Avenue) and 1 unit Bhubaneshwar in the Indian State of Odisha. The hospital had also opened a health center in Dhaka for its Bangladeshi patients.
This study evaluated the relationship between fixed flexion deformity (FFD), hip range of motion (ROM), and dynamic spinopelvic parameters, and explored factors associated with early postoperative sacral slope (SS) mobility in patients with advanced hip arthritis undergoing total hip arthroplasty (THA). In this prospective study, 45 patients with unilateral hip arthritis and FFD undergoing primary THA were evaluated preoperatively and at three months postoperatively. Clinical assessments included the Thomas test, hip ROM, Harris Hip Score (HHS), and Visual Analogue Scale (VAS) for pain. Radiographic measurements in standing and sitting positions included pelvic incidence, sacral slope, pelvic tilt, ante-inclination (AI), and pelvic–femoral angle. Spinopelvic mobility was defined by the change in sacral slope (ΔSS) between standing and sitting positions. The mean age was 56.2 years. Mean FFD improved from 16.4° preoperatively to 0° postoperatively, while hip flexion increased from 72.5° to 114.1°. Preoperatively, 11
Purpose This study evaluated the relationship between Fixed flexion deformity (FFD), hip range of motion (ROM), and dynamic spinopelvic parameters and identified predictors of early postoperative sacral slope (SS) mobility in patients with advanced hip arthritis undergoing total hip arthroplasty (THA). Methods In this prospective study, 45 patients with unilateral hip arthritis and FFD undergoing primary THA were evaluated preoperatively and at three months postoperatively. Clinical assessments included the Thomas test, hip ROM, Harris Hip Score (HHS), and Visual Analogue Scale (VAS) for pain. Radiographic measurements in standing and sitting positions included pelvic incidence, sacral slope, pelvic tilt, ante-inclination (AI), and pelvic–femoral angle. Spinopelvic mobility was defined by the change in sacral slope (ΔSS) between standing and sitting positions. Results The mean age was 56.2 years. Mean FFD improved from 16.4° preoperatively to 0° postoperatively, while hip flexion increased from 72.5° to 114.1°. Preoperatively, 11% of patients exhibited a stiff spinopelvic pattern, 63% had normal mobility, and 26% were hypermobile. Following THA, spinopelvic mobility shifted toward a more physiological distribution. Preoperative FFD correlated positively with ΔSS (r = 0.45, p = 0.002). Regression analysis identified preoperative hip ROM (β = −0.35) and dynamic AI (β = 0.23) as significant predictors of postoperative ΔSS. Conclusion Correction of FFD through THA improves spinopelvic mobility and promotes pelvic realignment. Preoperative hip ROM and dynamic AI predict early postoperative SS mobility, suggesting that acetabular component positioning based solely on preoperative spinopelvic parameters may not accurately reflect postoperative biomechanics in patients with substantial FFD.
IntroductionThe delay in diagnosis and management of cerebral aspergillosis leads to high mortality. The major challenges include low recognition of the disease, long turnaround time, and low sensitivity of available diagnostic modalities, and absence of standardized molecular diagnosis. Management is also suboptimal due to lack of optimal surgical strategies, the emergence of antifungal resistance, and poor penetration of antifungal drugs into the brain parenchyma. This article emphasizes new modalities for early diagnosis and optimal management that may improve outcomes. Area coveredWe searched the PubMed and Embase databases (since 2015 till 31 March 2025) using the terms 'cerebral aspergillosis,' 'diagnosis ca,' 'management ca,' and 'treatment ca.' The search was augmented by reviewing the references of those articles. Expert opinionEarly diagnosis may be achieved by high index of suspicion, neuroimaging, stereotactic brain biopsy, and the use of galactomannan in serum and cerebrospinal fluid. Whole-genome sequencing and detection of cell-free nucleic acid can improve diagnostic capabilities. Surgical debridement of infected tissue will reduce disease burden and allow enhanced antifungal drug penetration. Voriconazole, posaconazole, and isavuconazole are recommended as primary therapy and therapeutic drug monitoring guided higher doses of azoles may improve outcomes. Olorofim and fosmanogepix are promising agents for the future.
The color and physical appearance of pills influence people’s expectations of their effectiveness, alongside their actual medicinal purpose. Therefore, the present study aimed to evaluate how pill color influences medication adherence. This questionnaire-based survey was conducted among Indian patients visiting cardiologists with cardiovascular diseases. Patients were asked to fill out a form that included 9 questions designed to assess the impact of pill color on drug adherence. In addition, demographic characteristics of the patients were collected. A total of 901 patients were included in the study. Approximately 91% of the 876 patients reported that they were taking medications that needed to be taken daily. When taking multiple pills, 29.4% of patients remember the medication by the pill color, 28.4% remember by the strip color, and 28.0% remember by the brand name. The proportion of patients aged >50 years who reported that similar-looking medications confused identifying their medication was significantly higher compared to those aged ≤50 years (63.2% vs. 50.5%; P < 0.001). When managing multiple medications, female patients primarily relied on pill color (33.1% vs. 26.6%) and strip color (30.7% vs. 26.4%) for identification compared to male patients. The proportion of patients with a high school education who believed that unique pill colors could help in easy identification, reduce forgetfulness, and enhance medication adherence was significantly higher compared to those with a college education and above ( P < 0.001). This study emphasizes that pill color significantly aids in medication identification and adherence, particularly among older adults, women, and individuals with lower educational levels.
Managing atrial fibrillation (AF) in elderly patients with comorbidities is a clinical challenge requiring multiple strategies. They are at high risk of bleeding and thromboembolism requiring alternative approaches such as left atrial appendage occlusion (LAAO). Some of these patients may have symptomatic bradycardia with complete heart block and require permanent pacemaker implantation (PPI). However, there is limited global experience on the safety of simultaneous implantation of both devices through the same venous access. We report a case of simultaneous implantation of LAAO device and leadless pacemaker in a multi-morbid very elderly frail individual with Tachy-brady syndrome and high bleeding risk.
