Abstract Background The quadriceps tendon (QT) has emerged as a reliable autograft for anterior cruciate ligament reconstruction (ACLR), but uncertainty remains regarding several key comparative aspects—particularly donor-site morbidity, long-term graft survival, knee stability, and complication rates—when evaluated against hamstring tendon (HT) and bone–patellar tendon–bone (BPTB) autografts. High-level evidence restricted to randomized controlled trials directly comparing QT with HT or BPTB remains limited. To compare clinical outcomes, graft failure, donor-site morbidity, and knee stability among QT, HT, and BPTB autografts for primary ACLR using level-I and level-II randomized controlled trials (RCTs). Methods The MEDLINE (PubMed), Embase (Elsevier), and Cochrane Library databases were searched on 1 September 2025, and repeated 2 weeks later. Only level-I or -II RCTs comparing QT to HT or BPTB in primary ACLR were included. Random-effects meta-analyses were performed for International Knee Documentation Committee (IKDC) and Lysholm scores, instrumented laxity, graft failure, donor-site morbidity, and reoperation. Risk of bias was assessed with RoB 2.0, and small-study effects with funnel and doi plots. Results Eleven RCTs (mean follow-up, 2–10 years) were included. Pooled IKDC scores averaged 84.8 (95% CI 81.9–87.9) and Lysholm scores averaged 93.1 (95% CI 91.6–94.6), with no significant differences between QT and either comparator (P > 0.05). Side-to-side anterior tibial translation averaged 1.2 mm (95% CI 0.99–1.54 mm) across all grafts, also without significant differences (P > 0.05). Pooled graft failure and ipsilateral reoperation rates were 0.7% (95% CI 0.0–1.9%) and 2.3% (95% CI 0.6–4.7%), respectively, again with no between-graft differences (P > 0.05). Donor-site morbidity did not differ significantly between QT and HT (mean 13.83 [95% CI 9.6–19.83]; P > 0.05). Conclusion This meta-analysis of level-I/II randomized controlled trials found no statistically significant differences among quadriceps tendon, hamstring tendon, and bone–patellar tendon–bone autografts in patient-reported outcomes, knee stability, graft re-rupture, or additional knee surgery. Donor-site morbidity comparisons were limited by incomplete reporting, particularly for BPTB. These findings suggest that contemporary surgical techniques and rehabilitation protocols may minimize graft-specific differences in mid-term outcomes, although interpretation should consider the limited number of direct comparative trials across all three graft types. Level of evidence Systematic review and meta-analysis; level of evidence, 1 and 2.
Septic arthritis (SA) of the native knee is a severe and increasingly prevalent condition, particularly among elderly and comorbid patients. When associated with end-stage degenerative joint disease, a two-stage total knee arthroplasty (TKA) with an antibiotic-loaded articulating spacer is commonly adopted. However, evidence directly comparing different spacer designs is limited. The aim of this study was to compare the clinical and functional outcomes of two two-stage strategies: a preformed cement articulating spacer and a Hofmann-type metal-on-polyethylene articulating spacer. We retrospectively reviewed 15 consecutive patients treated between June 2022 and December 2024 at a tertiary referralcentre. Inclusion criteria were native knee SA with end-stage arthritis managed with planned two-stage TKA and minimum 12-month follow-up. Seven patients received a Hofmann spacer and eight a preformed cement spacer. The primary endpoint was septic failure, defined as recurrent infection requiring surgical intervention; secondary endpoints included functional outcomes (Knee Society Score [KSS], Oxford Knee Score [OKS], Forgotten Joint Score [FJS]), pain (VAS), and range of motion (ROM) during the interstage period and after reimplantation. Mean follow-up was 24.2 months. Infection eradication was comparable between groups, with one reinfection (6.7
Although the Woven EndoBridge (WEB) device is increasingly used for the treatment of wide-neck intracranial aneurysms, including in the acute rupture setting, comparative evidence assessing the impact of rupture status remains limited. This study compared angiographic, safety, and clinical outcomes between ruptured and unruptured intracranial aneurysms treated with WEB. We conducted a retrospective analysis of prospectively collected data from the multicenter cohort registry WorldWideWEB, including consecutive adult patients with intracranial aneurysms treated with the WEB. Patients were stratified into groups of ruptured and unruptured aneurysms. Propensity score matching was used to balance baseline characteristics between both groups. Retreatment rate was the primary outcome. Secondary outcomes included mRS, safety events (thromboembolic complications) and angiographic outcomes (periprocedurally and last follow-up). Among 1,220 patients, 342 (28.0
In robotic medial unicompartmental knee arthroplasty (mUKA), a preoperative alignment strategy can be defined and subsequently adjusted through stress testing to achieve optimal soft-tissue balance. However, the application of uniform planning principles does not necessarily yield equivalent balance in all patients. The aim of this study was to examine differences in intraoperative balance according to patient sex and the degree of preoperative varus deformity. A single-center retrospective cohort study including 254 MAKO® robotic-assisted medial UKAs (2018–2025) was performed using a uniform intraoperative planning protocol. Gap widths were measured in millimeters at full extension and 90° of flexion (F90) and classified as tight (< 0.5 mm and negative values), balanced (0.5–2 mm), or loose (> 2 mm). Patients were stratified by sex and preoperative varus severity, and gaps were analyzed quantitatively and categorically. The independent effects of sex, varus deformity, and operating surgeon on extension and flexion gaps has been assessed. Mean preoperative alignment was 174.2 ± 2.8°, with no sex-related difference in baseline varus (p = 0.058). Flexion gaps were significantly tighter in female patients (p = 0.0045). A tight F90 gap was observed in 17.2
