Bingham University

Biophilic design provides an architectural approach for introducing contact with natural environmental qualities into healthcare settings, yet its application within rehabilitation architecture in Nigeria remains insufficiently documented. This study assessed the provision of selected biophilic design attributes at Amazing Healthcare and Rehabilitation Centre, Abuja, and examined their recognition among patients and healthcare staff. A descriptive case study design combining architectural assessment and questionnaire administration was adopted. Six attributes were assessed: indoor plants and green walls, natural light and daylighting, water features, views of outdoor landscapes and gardens, natural materials, and biomorphic forms and organic patterns. A study developed Biophilic Design Assessment Checklist was used to assess observed provision on an ordinal scale from 0 to 100, while 43 valid questionnaire responses were analysed using frequencies and percentages. Natural light and daylighting recorded the highest provision score at 60/100. Indoor plants and green walls, views of outdoor landscapes and gardens, natural materials, and biomorphic forms and organic patterns each recorded 20/100, while no water feature was observed. Respondent recognition was highest for indoor plants and green walls (76.7%), followed by natural light and daylighting and water features (67.4% each), and views of outdoor landscapes and gardens (65.1%). The findings indicate a clear difference between respondents’ recognition of biophilic qualities and their physical provision within the facility. They also establish the importance of giving greater architectural attention to natural environmental qualities in rehabilitation settings. The findings provide a basis for strengthening biophilic design consideration in rehabilitation facilities across Nigeria, particularly through appropriate provision of daylight, vegetation, landscape views, natural materials and outdoor spaces. The study does not establish clinical or psychological effects of biophilic design, but provides a structured basis for advancing its consideration in rehabilitation architecture and for further investigation across Nigerian healthcare facilities.

This study investigated anti-fibroid potential of Piliostigma thonningii leaf extract using in vivo hormonal and histopathological evaluations of the ethanolic extract in female wistar rats complimented by in silico molecular docking of phytochemical compounds. In vivo fibroid induction with diethylstilbestrol and progesterone significantly increased serum estradiol and progesterone levels (p < 0.05), accompanied by cystic degenerative changes in uterine and ovarian tissues. Treatment with P. thonningii crude extract (250 and 500 mg/kg) significantly reduced elevated hormone levels as well as showed observable improvements in uterine gross morphology and histopathological features. Molecular docking of thirty-one phytoconstituents identified via GCMS profiling of the plant's crude ethanol extract were docked at the ligand-binding domains of progesterone receptor (PR, PDB ID: 4OAR) and estrogen receptor (ER, PDB ID: 1QKU) using AutoDock Vina to explore possible mechanistic interactions. Among the top-ranked compounds, cyclopropaneoctanal-2-octyl exhibited favorable predicted binding interactions with key catalytic residue for PR (CYS891 and THR894) and ER catalytic residue (HIS524) comparable to the reference ligands ulipristal acetate and estrogen. Drug-likeness and ADMET prediction suggested that this compound possess acceptable pharmacokinetic properties and dynamic stability. These findings indicate that P. thonningii extract exerts anti-fibroid effects in vivo while in silico analysis provide mechanistic hypotheses regarding the potential contribution of the individual compounds to estrogen and progesterone receptor modulation.

Hypertension is a leading contributor to cardiovascular morbidity and mortality and a major driver of the noncommunicable disease burden in low- and middle-income countries. In Nigeria, prevalence estimates vary widely due to methodological heterogeneity across studies. We conducted a systematic review and meta-analysis to generate a current and geographically representative pooled estimate of hypertension prevalence among Nigerian adults. To estimate pooled prevalence of hypertension in Nigeria and examine subgroup differences. We conducted a systematic review and meta-analysis of primarily cross-sectional studies to estimate the pooled prevalence of hypertension and examine subgroup differences (sex, settings, and geopolitical zones). Eligible studies were identified through comprehensive database searches and screened according to predefined inclusion criteria. Pooled estimates were calculated using a random-effects model to account for between-study variability. Seven databases (MEDLINE, EMBASE, Scopus, Web of Science, CINAHL, PsychInfo, and African Journals Online) were systematically searched for primary studies published from January 2015 to September 2025. Eligible studies measured hypertension among adult Nigerians 18 years and above as systolic blood pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg or on antihypertensive medication). Titles and abstracts were screened, data were extracted, and the quality of studies evaluated by two independent reviewers using the Newcastle-Ottawa Scale. Heterogeneity was assessed through Q-test, I2, tau2, and 95

We study a new Halpern-type iterative process enhanced with both inertial and error terms for the approximation of fixed points of pseudocontractions and zeros of monotone operators in real Hilbert spaces. Implementation of our algorithm is illustrated using numerical examples in real Hilbert spaces. It complements the results of Qihou (J Math Anal Appl 148:55–62, 1990) which are proved in compact, convex subset C of a real Hilbert space H and which is restricted to continuous pseudocontractions T:C→ C with finite set of fixed points F(T) and the results of Zegeye et al. (Nonlinear Anal 74:7304–7311, 2011) which are proved for Lipschitz pseudocontractions T:C→ C where C is a nonempty closed convex subset of H and the interior of F(T) is nonempty. In all our examples, our algorithm enhanced with inertial and error terms is faster than the algorithms in Chidume and Zegeye (Proc Am Math Soc 132(3):831–840, 2004), Osilike et al. (J Appl Math Inform 31(3–4):565–575, 2013) and several other recent results which also yield strong convergence result for our class of maps. Extensions to double inertial schemes are also discussed.

This study examines how manufacturing emissions, urbanization, and globalization impact Nigeria’s crop production (1981–2023) using the ARDL approach. Results show emissions harm agriculture, while urbanization and globalization boost it via demand, infrastructure, and technology. The structural breaks highlights political and economic shifts for the sampled country. Thus, stricter environmental regulations, strategic urban planning, and leveraging globalization for technology transfer and investment are essential to balancing industrial growth, sustainability, and agricultural productivity.