Rescue stenting (RS) is increasingly used for intracranial artery stenosis-related large vessel occlusion (ICAS-LVO), but optimal patient selection remains uncertain. We investigated the baseline and procedural factors associated with receiving RS and whether they modified the association between RS and clinical outcome. This retrospective multicenter study included patients with middle cerebral artery (MCA) ICAS-LVO treated with mechanical thrombectomy (MT) alone or MT followed by RS. Baseline and procedural characteristics associated with receiving RS were identified using multivariable logistic regression and incorporated into inverse probability of treatment weighting models to assess treatment-effect heterogeneity for the 90-day modified Rankin Scale score. Among 264 patients, 193 received RS and 71 MT alone. MT failure, severe stenosis (> 75
AIM:Older adults living with type 2 diabetes represent a particularly vulnerable population. We investigated which continuous glucose monitoring (CGM)-derived targets are associated with all-cause mortality in this population. METHODS:HYPOAGE is prospective multicenter study including 141 insulin-treated older adults living with type 2 diabetes aged 75 and older, under insulin therapy for at least 6 months. All participants underwent standardized geriatric and diabetic assessments and wore an ambulatory blinded CGM (FreeStyle Libre Pro®) for 28 consecutive days. In this ancillary study, multivariable cox regressions were performed to identify factors associated with mortality after adjustment for age, sex, HbA1c, kidney function, geriatric status, and metformin use. RESULTS:At baseline, participants were 81.5 years old on average. After a median follow-up of 44 months, 58 of 141 patients had died. In adjusted model, higher percentages of level 1 time below range (TBR), level 2 TBR and glycemic variability assessed by the coefficient of variation (CV) were independently associated with an increased mortality risk (hazard ratio [95% CI] 1.51 [1.11; 2.06], 1.25 [1.02; 1.53], and 1.76 [1.21; 2.56] for an interquartile range (IQR)% increase of each parameter, respectively). When recommended CGM targets were considered, only glycemic variability (CV ≤ 36%), remained significantly associated with a lower risk of mortality (hazard ratio 0.57 [0.32; 0.99]), whereas TIR > 50% and TBR ≤ 1% were not. CONCLUSION:Among insulin-treated older adults living with type 2 diabetes, glycemic variability was independently associated with all-cause mortality, highlighting its potential relevance for clinical management in geriatric diabetes care.
Although recommended for the early identification and intervention for developmental impairments, monitoring of preterm infants over several years is hampered by loss of follow-up that inevitably occurs. This study aimed to assess the non-participation of preterm infants in their two- and five-year visits as well as associated factors. Infants born before 33 weeks of gestational age, who were enrolled between 2016 and 2022 in a prospective, population-based cohort in Paris area, France, and were eligible for their two- and five-year visits were selected. Among factors reflecting parental socio-economic characteristics, medical characteristics of the mother and her pregnancy, perinatal characteristics of the child, and contextual variables, those associated with the likelihood of non-participation in the two- or five-year visit were investigated using univariate and multivariable logistic regression models and multiple imputations. Of the 12,685 and 6,661 preterm infants followed-up at two- and five-years, respectively, 4,871 (38.4
Poor glycaemic control in type 2 diabetes is associated with low bone turnover and skeletal fragility. Osteocalcin has been linked to glucose homeostasis, but its short-term response to rapid improvement in chronic hyperglycaemia in adults remains insufficiently described. We conducted a single-centre observational comparative study in adults with type 2 diabetes. Group 1 had chronic poor control (HbA1c > 8.5
