Escuela de Emprendedoras Juana Millán
Este estudio examina las percepciones de jóvenes universitarias en Perú sobre los discursos de género y empoderamiento femenino presentes en la publicidad. A través de un enfoque cualitativo, se exploran las interpretaciones y reacciones de estas jóvenes ante la representación del género en la publicidad, enfocándose en identificar los elementos que influyen en sus percepciones de autenticidad y oportunismo. El análisis revela que, dentro de estas percepciones, emerge el fenómeno del femvertising como una preocupación significativa, donde se cuestiona la sinceridad de las marcas en su compromiso con el empoderamiento femenino. Este hallazgo subraya la complejidad de la relación entre publicidad, género y cultura en el contexto peruano.
e14033 Background: IDH-mutant tumors are a distinct disease entity accounting for one third of gliomas with a more favourable prognosis despite still harboring high morbidity and mortality rates. Most IDH mutations (muts) in gliomas group at R132/R172 hotspots in IDH1/IDH2, respectively. Our aim was to study IDH non-canonical muts and IDH co-mutations (co-muts) since the evidence is still limited. Methods: Prospective study of patients (pts) with gliomas at 4 third-level hospitals in Spain (Hospital Clinico Universitario San Carlos, Hospital Universitario La Paz, Hospital Universitario de Canarias, Hospital Universitario Nuestra Señora de la Candelaria). High throughput next generation sequencing (NGS) using a customized gene panel ((Illumina, Inc) including IDH1 and IDH2 was used in FFPE and/or fresh tumor samples, and run in an Illumina MiSeq instrument (Illumina, Inc). Only pathogenic mutations were considered as valid. Clonal IDH (cIDH) muts were defined as those with a MAF ≥ 1% and subclonal IDH (scIDH) muts as those with a MAF < 1%. Results: Between February 2017 and February 2021, 49 glioma pts enrolled and sequenced for IDH1/IDH2 tumor muts. Median age 51 (Min-max: 20-78). WHO 5th Ed (n = 42): IDH-MUT astrocytoma (n = 14), IDH-MUT oligodendroglioma (n = 7), IDH-WT glioblastoma (n = 21). 37/49 pts (75.5%) presented cIDH and/or scIDH muts, of which 21 pts (43%) harbored cIDH muts in IDH1 (R132H (n = 17), R132C (n = 1), R132G (n = 1), R100Q (n = 1), G161R (n = 1)) and in IDH2 (R140W (n = 1), R140Q (n = 1)). In 17/21 pts (81%) cIDH-mut MAF ≥ 10%. Of 21 cIDH-mutant pts, there were IDH co-muts in 11 pts (52%). Of these 11 pts, IDH co-muts were scIDH in 91%: #2 (IDH1 R100Q/G161R), #3 (IDH1 R132H/R119Q/G161R), #4 (IDH1 R132H/R132C; IDH2 R172G/R140Q), #11 (IDH1 R132H/R132C), #21 (IDH1 R132H/G161R; IDH2 R140Q), #23 (IDH1 R132H/R132C), #31 (IDH1 R132H/G161R; IDH2 R140Q/P162L), #32 (IDH1 R132H/R100Q), #33 (IDH1 R132H/R100Afs*29/I130V), #37 (IDH1 R132H; IDH2 R159H), #40 (IDH1 R132H; IDH2 R172G). Median overall survival (OS) longer in cIDH-mut vs IDH-wt (159 vs 16 months, P = 0.000). No difference in OS in: cIDH vs cIDH + scIDH (NR vs 67 m, P = 0.437), in scIDH vs cIDH (79 vs 159 m, P = 0.111), and scIDH vs IDH-wt (79 vs 12 m, P = 0.229). Conclusions: Subclonal (defined as MAF < 1%) canonical and non-canonical IDH-mutations and co-mutations occur frequently in gliomas. This may have implications for the design of future clinical trials and in the development of IDH inhibitors including the anticipation of potential resistance mechanisms.
Biodiversity is under threat in Haiti. FAO, in its 2020 report on the state of the world's forests, indicates that forest coverage in Haiti represents 12.6% of its territory; thus, this lack in wooded areas increases its vulnerability to natural disasters. To try recovering in losses of forest coverage and biodiversity at the local level, the organization of farmers in Vallue a rural area of Petit-Goâve (a city in the western department), has mobilized its members, taped to its resources and embarked into reforestation projects while helping to improve habitat in the village. This research analyzes the relationship among biodiversity resources in reforestation projects involving native and exotic species, habitat and landscape transformation in an environment that is vulnerable to natural disasters with the goal to seek for solutions that can benefit rural communities. A field investigation is conducted with 156 families who live in the village and a series of satellite images are analyzed to evaluate the percentage of forest coverage. The results obtained indicate habitats are destroyed by disasters that regularly hit the region; reforestation projects that include exotic species do not have adverse effects on native ones and wooded areas are improved in the village of Vallue. Furthermore, the landscape retains a visual quality that can facilitate the valorization of the territory. It is proposed that reforestation projects with plants that resist to high winds to be used and develop a bio-reactive habitat that may reduce the vulnerability of rural families living in areas too often struck by hurricanes.
The Cetaceans of Mauritania, West Africa: a concise zoogeographical review with two new species records
