CEU San Pablo University (Spanish: Universidad CEU San Pablo) is a private Catholic university in Madrid.It is involved in a number of academic exchange programmes with renowned universities worldwide (Columbia, Chicago, Duke, Boston, Colgate), work practice schemes and international projects with over 200 higher education institutions in Europe, Latin America, North America and Asia.It is run by the CEU Foundation..
Biological invasions, driven by the spread of non-native species, have become a critical global issue because of their far-reaching ecological and socioeconomic impacts. Effective communication of the risks of biological invasions is essential for implementing robust policy and legislation and gaining public support for conservation efforts. However, current policies often suffer from fragmentation and ineffectiveness, largely due to inadequate risk communication and complex multi-level governance. To address this challenge, we develop a global framework designed to enhance clearer communication about biological invasion risks. The framework contextualizes key terms across three domains in invasion science: species invasiveness, risk analysis, and decision support tools. Using both diffusion-of-English and ecology-of-language paradigms, and following a three-step process involving preliminary consensus, AI querying, and ground-truthing with final consensus, we validate the framework in 70 non-English languages which, together with English, have official status in at least one country and collectively cover all 195 countries worldwide. Our findings reveal that while terminology for risk analysis is well established, terminology for species invasiveness and, especially, for decision support tools remains underdeveloped in many languages, hindering effective communication and policy implementation. Our framework underscores the importance of cultural and political neutrality. By promoting clearer risk communication among scientists, policymakers, and the public globally, we aim to reduce policy fragmentation and foster enhanced collaboration in risk mitigation. We recommend expanding multilingual decision support tools to include the full risk analysis process: risk identification, risk assessment, and risk management. This will support intergovernmental mitigation efforts and promote a unified global response to biological invasions.
The numerical simulation of composite materials brings in a challenge in the resolution of problems with a high nonlinearity of both, material, and geometry (geometrically complex structures), with different size scales. Some common examples such as additive manufacturing 3D, metal alloys, porous media, polycrystalline materials and composites, a significant computing challenge is shown where all length scales are resolved by a single finite element model. This would require many elements, and computing the solution would be unfeasible, even using modern and near-future computing resources. The standard way to solve this situation of scale in finite element analysis is numerical homogenization technique. Material properties for a composite material are average, instead of simulating the full microstructure. With homogenized material data, it only required a macroscopic simulation using significantly less computational sources. The mechanical behavior of composites materials reinforced with natural fibers, is studied by means of a short fiber composite numerical model. The influence that the spatial distribution and the volumetric fraction of the cylindrical fibers have on the effective elastic properties of the numerical model was established (Youngs modulus E, Shear modulus G, Poissons ratio)-curves are presented corresponding to tension test applied on fique fibers and polylactic acid-biopolymer.
PurposeThis study investigates how experiences generated in digital environments - specifically perceived personalization and brand sensory experience - impact the experiential value of physical in-store interactions within the fashion industry. Additionally, it examines the extent to which consumer sensory orientation modulates these effects in omnichannel contexts.Design/methodology/approachA quantitative research design was employed, structured around an experiment combining a simulated digital shopping journey, in-person exposure, and the administration of a standardized questionnaire. The sample, consisting of 445 participants, was recruited through Prolific. Data were analyzed using exploratory and confirmatory factor analyses (EFA and CFA), hierarchical regression models, and interaction tests with bootstrapping, ensuring psychometric robustness and external validity.FindingsThe results reveal that digital personalization, when lacking coherent sensory alignment, may diminish the perceived value of the in-store experience. Conversely, the online brand sensory experience significantly enhances such valuation. Furthermore, consumers with high sensory orientation amplify these effects: they exhibit greater positive responsiveness to sensory stimuli and lower receptivity to personalizations perceived as generic or intrusive.Originality/valueThe primary contribution of this study lies in integrating, within a single explanatory model, the effects of digital experiences on physical evaluations through a sensory and personalized lens. By introducing consumer sensory orientation as a moderating variable, this research advances understanding of omnichannel behavior and offers a more nuanced perspective on the design of effective hybrid experiences in the retail sector. It provides both theoretical insights and managerial implications in a landscape increasingly shaped by technological convergence.
Breast cancer is a highly heterogeneous malignancy, characterized by diverse genetic, epigenetic, and phenotypic variations, as well as by metabolic reprogramming and oxidative stress. Lipid peroxidation bioactive product 4-hydroxynonenal (4-HNE) plays a significant role in the development and progression of cancer. In this study, we quantified circulating 4-HNE-modified proteins and performed comprehensive untargeted metabolomic profiling of the patients' plasma using LC-ESI-QTOF-MS and GC-EI-QMS, aiming to investigate systemic metabolic pathways associated with oxidative damage in breast cancer. Significantly elevated levels of 4-HNE-modified proteins were detected in breast cancer patients compared to healthy controls, accompanied by distinct metabolomic signatures enriched in lipid metabolism. Several metabolites, including specific long-chain fatty acids, exhibited significant correlations with circulating 4-HNE-modified proteins, suggesting an interaction between lipid peroxidation-driven protein modification and breast cancer-associated metabolic reprogramming. Overall, this study provides evidence of associations between systemic 4-HNE-mediated protein modification and altered metabolic profiles in breast cancer, highlighting oxidative stress-related metabolites as potential biomarkers and pointing to redox-metabolic crosstalk in breast cancer patients.
Introduction:Digital impression techniques have gained popularity in dentistry due to their potential advantages in accuracy, efficiency, and patient comfort. This systematic review aims to evaluate and compare the accuracy, chairside time, and patient perception of conventional vs. digital impressions. Methods:A systematic search was conducted in Medline/PubMed, EBSCO, Web of Science, and Scopus databases. Inclusion criteria comprised clinical or in vivo studies comparing conventional and digital impression techniques in terms of accuracy, working time, and/or patient comfort. Reviews, meta-analyses, editorials, and studies involving fully edentulous patients or edentulous spans exceeding two teeth were excluded. Study quality was assessed using the QUADAS-2 tool, and intra-operator agreement was evaluated using the Cohen's Kappa statistic. Results:From 269 initially identified articles, 10 met the inclusion criteria. All studies assessed accuracy; only two evaluated working time and patient comfort. The included studies, published between 2016 and 2024, were cross-sectional observational in design, with sample sizes ranging from 5 to 50 participants. A variety of intraoral scanners were evaluated, including Cerec, Trios, iTero, and Primescan. The QUADAS-2 tool indicated an overall unclear risk of bias in patient selection and mixed concerns regarding applicability. While findings on accuracy were mixed, most studies concluded that both techniques are clinically acceptable, with conventional impressions performing better in full-arch cases. Digital impressions were consistently reported as faster and more comfortable for patients. Limitations:The findings of this review should be interpreted with caution due to methodological heterogeneity, small sample sizes, and the inclusion of predominantly young, fully dentate participants. Conclusion:Intraoral scanners offer advantages in workflow efficiency and patient experience, although conventional impressions remain reliable and widely used. The variability in study designs and outcome measures underscores the need for standardized evaluation protocols in future research. Systematic Review Registration:https://doi.org/10.17605/OSF.IO/62RCY.