Dr. D. Y. Patil Medical College, Hospital & Research Centre is a medical college facility located in Pune, India. It is named after D. Y. Patil or Dnyandeo Yashwantrao Patil. It has 250 undergraduate seats for MBBS course.
Oral squamous cell carcinoma (OSCC) and basal cell carcinoma (BCC) are epithelial malignancies with distinct etiologies. We report a rare case of synchronous OSCC and BCC in a 62-year-old female with comorbidities. The patient was non-syndromic, obese, and had no history of adverse habits. An initial biopsy of buccal mucosa lesion confirmed moderately differentiated squamous cell carcinoma (grade II). The patient underwent composite resection of the left buccal mucosa lesion along with marginal mandibulectomy and reconstruction. In view of suspicious clinical appearance, excisional biopsy of the adjacent skin lesion was performed. Histopathological examination of the intraoral lesion revealed poorly differentiated squamous cell carcinoma (PDSCC) and extra oral lesion as BCC. The patient was subsequently planned for adjuvant postoperative radiotherapy for buccal mucosal lesion. In conclusion, this case highlights the importance of timely diagnosis and multidisciplinary management for improved outcomes. Clinicians should maintain a high index of suspicion for synchronous malignancies in elderly patients with comorbidities, even in the absence of traditional risk factors.
Cancer remains a major global health challenge. Current diagnostic and therapeutic strategies are often limited by the complexity and heterogeneity of the disease. Long non-coding RNAs (lncRNAs) have recently emerged as important regulators of cancer. They influence tumor initiation, progression, metastasis, immune evasion, and therapy resistance. This review summarizes the clinical significance of lncRNAs and their potential as tools for cancer diagnosis, prognosis, and treatment. We describe their molecular functions, including interactions with DNA, RNA, and proteins, and explain how they regulate oncogenic pathways, contribute to drug resistance, and modulate immune responses. We also highlight the translational potential of lncRNAs as diagnostic and prognostic biomarkers, as well as therapeutic targets in multiple cancer types. Completed and ongoing clinical trials further support their relevance, particularly in cancer immunotherapy and lncRNA-based vaccine development. Despite these advances, important challenges remain. Efficient delivery, target specificity, and robust clinical validation are still major hurdles. Emerging strategies aim to address these issues and improve the clinical feasibility of lncRNA-based approaches. By integrating current molecular insights with clinical progress, this review underscores the promise of lncRNAs in oncology. They hold significant potential to advance precision medicine and shape future directions in cancer management.
ABSTRACT Background: Selfie-taking is increasing nowadays, mainly in the younger age group. Aim: To assess the proportion of selfie-taking in male and female medical undergraduates and its relation to self-esteem. Materials and Methods: A cross-sectional study was carried out on consenting medical undergraduates who were assessed using a self-prepared semi-structured questionnaire about their demographic characteristics and selfie-taking habits. Self-esteem was assessed using the Rosenberg Self-esteem scale. Information obtained was analyzed using SPSS 20. Results: The majority of participants were females (56%). Compared to males, more females were found to be involved in selfie-taking, with the majority in the third year (68%). Most of the participants took 0–3 selfies/day. Regarding selfie-taking, 48% of study participants felt it was fun, 38% expressed that it allows them to control how they present themselves, and 28% commented that it could turn deadly or disastrous if not used promptly. The majority of medical undergraduates had normal self-esteem. Multiple regression analysis revealed that addictive behaviors and body shaming were significant negative predictors of self-esteem scores. Conclusion: Selfie-taking behavior is widespread among young adults, with no significant gender differences in frequency or motivation. Females reported more body shaming and associated selfies with risk, but the overall impact on self-esteem was minimal. The study highlights the detrimental roles of addictive behaviors and body shame in predicting self-esteem. The normalization of selfie culture may have diluted its differential impact across genders. Selfie-seeking behavior is not related to self-esteem.
