Dum Dum Motijheel College, established in 1950, is a bachelor's degree college in Kolkata, India. It offers undergraduate courses in Science and Arts. It is affiliated to West Bengal State University.
Raja Ram Mohan Roy, commonly known as the “Father of Modern India” or the “Father of Indian Renaissance,” was a famous Indian reformist who brought reforms in various fields of social, religious, and education. He tried to convert India into a modern nation with his modern and scientific thoughts. His ideas and thoughts tried to merge the gap between traditional Indian high values and modern western rationalism. He promoted rationalism and asked the Indians to build a new modern India with rationalism and scientific thoughts. He presented several bold ideas and thoughts for various social, religious, and educational reforms and used newspapers and periodicals as a tool of communication. The article entitled “Raja Ram Mohan Roy: The Beginning of Vernacular Newspaper in India and the Reforms” depict how Raja Ram Mohan Roy uses vernacular and English newspapers and periodicals to bring social, religious, and educational reforms in India and to challenge the press restrictions imposed by the British colonial government.
The clinical utility of platinum-based chemotherapeutics is limited by severe toxicity and acquired resistance, motivating the development of alternative metallo drugs. Here, we report a series of rhenium complexes, Re[HL1-4]3, synthesized via reduction of Re(VII) precursors followed by coordination with aromatic thiohydrazide ligands. The lead complex, Re[HL2]3, adopts an unusual trigonal-prismatic geometry and a favorable redox profile, correlating with enhanced cytotoxic potency. It demonstrates selective antiproliferative activity against cancer cells with minimal toxicity toward nonmalignant cells in both 2D and 3D culture systems. Mechanistic studies reveal DNA binding, induction of DNA damage, and reactive oxygen species (ROS) generation, triggering apoptosis via PARP and caspase 3 cleavage. Pharmacokinetic analysis indicates moderate stability and plasma retention, supporting sustained therapeutic levels while limiting accumulation-related toxicity. In a syngeneic 4T1 murine breast cancer model, Re[HL2]3 significantly inhibited tumor growth without observable systemic toxicity, supporting its further preclinical evaluation.
Lichens are extraordinary organisms known for their ability to thrive in harsh climates, some of which are akin to the environmental conditions found on Mars. Despite extensive research, mysteries still shroud the mechanisms underlying lichen survival in such extreme environments. Numerous studies have investigated the resilience of various lichen species in space and simulated Martian conditions. Especially, evidence supporting their classification as extremophiles is multifaceted: (i) experiments conducted aboard the International Space Station (ISS) have further demonstrated their capacity to withstand extreme conditions akin to those found on Mars, (ii) scrutiny of Martian surface imagery has prompted speculation regarding the presence of structures resembling lichens, and (iii) observations in extreme terrestrial environments suggest the potential for lichens to inhabit Martian rocks, hinting at the existence of “endolithic lichens”. Under this scenario, this work encapsulates the multifaceted evidence based on the data analytic techniques supporting the extremophilic nature of lichens and their potential implications for understanding life beyond Earth. However, the results thus obtained do not claim a full-scale positive signature of the existence of lichen rather provide a statistical high probability and demand further experimental evidences.
The ferromagnetism in Cu doped Zinc oxide (ZnO) has been investigated and the possible origin of magnetism in the system has been discussed. The Cu doped ZnO has been successfully prepared by solid state reaction method. Magnetization measurement of these Cu doped ZnO samples show ferromagnetic behavior at room temperature. Room temperature Photoluminescence spectroscopy measurements shows defect related blue emission peak together with the UV emission. Employing positron annihilation spectroscopy all the Cu doped and undoped ZnO samples has been characterized. Positron annihilation lifetime results suggest no significant increase of cation defect in Cu doped ZnO.
