Faisalabad Medical University (Urdu: فیصل آباد جامعه طب; abbr. FMU), is located in Faisalabad, Pakistan, on a 158-acre (0.64 km2) campus on Sargodha Road. It was established in 1973. Teaching hospitals affiliated with the university are Allied Hospital, District Headquarters Hospital and Government General Hospital Ghulam Muhammad Abad Faisalabad. The chief executive is Dr. Zafar Chaudhry, a laparoscopic surgeon. The first group of graduates with M.B.B.S degrees finished in 1978.With a grant of Rs. 460mn from the government, the construction of new buildings, laboratories and the teaching hospital was completed in 1982. FMU is recognized with the General Medical Council based in London, England, and is listed on World Directory of Medical Schools (it was also listed in the now discontinued International Medical Education Directory).
Glioblastoma (GBM) remains the most common and lethal primary central nervous system tumor, with a median survival of only 14.6 months under standard care. The tumor’s characteristic "Warburg effect"—a dependency on aerobic glycolysis for energy—creates a metabolic vulnerability. This review evaluates the efficacy and safety of the ketogenic diet (KD) as an adjunctive metabolic therapy aimed at exploiting this glucose dependency. This PRISMA-compliant systematic review updates clinical evidence by synthesizing data from databases from 2000 to September 2025. We searched PubMed, Embase, Cochrane, and Web of science for human studies assessing the ketogenic diet (KD) in glioblastoma and high-grade gliomas. Primary outcomes included overall survival (OS), progression-free survival (PFS), feasibility, and adverse events. Study quality was assessed using Joanna Briggs Institute tools. Prospero registration: CRD420251232650. Forty-one studies were included, ranging from randomized trials to case series and abstracts, utilizing interventions such as the classic 4:1 ketogenic diet, Modified Atkins Diet, and calorie restriction. Adherence was high (> 75
Endovascular options for infrapopliteal artery disease include plain balloon angioplasty (PTA), drug‑coated balloons (DCB), drug‑eluting and bare‑metal stents (DES), and atherectomy. Retrievable scaffold therapy (RST) has recently emerged as a temporary scaffolding strategy used with DCB, but its comparative effectiveness remains uncertain. A comprehensive literature search identified 21 randomized and 4 single‑arm trials (n = 3184). Eligible studies reported at least one prespecified outcome: 30‑day major adverse events (MAE), 12‑month all‑cause mortality, 6‑month clinically driven target lesion revascularization (CD‑TLR), or 6‑month major amputation. Random‑effects models generated odds ratios (ORs) with 95
Congenital sensorineural hearing loss (CSNHL) is a very common subtype of pediatric hearing loss disorders. Less severe deformities in CSNHL might not be recognized during a simple visual inspection in computed tomography (CT) of the temporal bone. Therefore, the present study aimed to compare the inner ear measurements between CSNHL patients with grossly normal CT appearance and the healthy population. Children with confirmed CSNHL were enrolled along with a control group of healthy children. Their CT scans of the temporal bone were retrospectively reviewed. Ten inner ear radiologic measurements, including cochlea height (CH) and width (CW), width of cochlear nerve bony canal (WCN), superior and lateral semicircular canals (SSCC and LSCC) bony island widths, posterior semicircular canal (PSCC) inferior limb length, vestibule height (VH) and width (VW), and vestibular aqueduct (VA) width at the midpoint and operculum were compared between the two groups. 62 children (30 CSNHL, 37 females, mean age: 7.1 ± 3.4 years) were included. The intra-observer repeatability was very good to excellent across all parameters (Intraclass correlation coefficient: 0.83–0.96). CH (P ≤ 0.001) and VA midpoint width (P ≤ 0.001) were significantly higher in CSNHL patients than healthy individuals, and WCN (P ≤ 0.001), SSCC bony island width (P ≤ 0.001) and LSCC bony island width (P = 0.01) were significantly lower. There was no statistically significant difference in terms of CW (P = 0.83), PSCC inferior limb length (P = 0.54), VH (P = 0.67), VW (P = 0.83), and VA operculum width (P = 0.15). WCN (ROC-AUC: 0.80, cut-off point = 1.9 mm, sensitivity = 60
Aortic Dissection (AD) is a life-threatening condition and one of the major causes of death in the U.S. Despite its clinical significance, trends in AD related mortality remain understudied. We aim to analyze nationwide mortality trends in AD in the U.S. Data from CDC WONDER (1999–2024) identified U.S mortality rates in adults aged ≥ 25 years with AD (ICD-10: I71.0). Crude mortality rates (CMRs) and age-adjusted mortality rates (AAMRs) per 100,000 were calculated. Trends were analyzed using Joinpoint regression to estimate annual percent change (APC) and average annual percent change (AAPC). From 1999 to 2024, a total of 115,449 deaths from AD were recorded. The AAMR increased from 2.1 in 1999 to 2.4 in 2024 (AAPC of 0.46; 95
Hospital-acquired infections (HAIs) associated with increasing antimicrobial resistance (AMR) are becoming a global health challenge, causing AMR spread and a serious health threat. This study was designed to evaluate the phenotypic and genotypic status of AMR in Gram-negative HAI-associated bacteria, to gain a current insight into the local settings. Kirby-Bauer method and Double Disc Synergy Test were used for phenotypic assessment of AMR and extended-spectrum β-lactamase (ESBL) producers, respectively. Genes encoding antimicrobial resistance, ESBLs, and carbapenemases were identified by PCR followed by Sanger sequencing. Among 102 HAI samples, 62 were Gram-negative, identified as Escherichia coli (E. coli) (42.2
