Gujarat Cancer & Research Institute (GCRI) is a state owned cancer research institute in Gujarat, India. It was established in 1972. It is one of the 25 government funded Regional Cancer Centres in India.
Esophageal cancers ranked the sixth leading cause of cancer-related mortality, pose a significant health challenge in India. Neo-adjuvant chemoradiotherapy (NACTRT) followed by surgery is the current standard, yet its outcomes among Indian patients remains unclear. Many patients receiving NACTRT default therapy or do not proceed with the surgical procedure due to various factors. Our aim in this study was to elucidate the diverse factors contributing to this phenomenon and obtain a comprehensive understanding of the issue. This analysis was done on the data of esophageal cancer patients treated at our institute, between January 2019 and December 2023. The study included the patients with biopsy-proven, non-metastatic squamous cell carcinoma/ adenocarcinoma of the middle and lower third esophagus, ranging from cT1 to T4 and N0 to N3 stages, who underwent NACTRT as per our institutional protocol. Data from electronic databases and patient case-sheets, supplemented by telephonic interviews, provided insights into the treatment outcomes and reasons for treatment discontinuation. Of 227 patients receiving NACTRT, 81 (35.7
Vulvar cancer is a rare gynecological malignancy accounting for approximately 5
Philadelphia chromosome-positive (Ph+) B-cell acute lymphoblastic leukemia (B-ALL) by the t(9;22)(q34;q11.2) translocation produces the BCR-ABL fusion gene and tends to have an aggressive clinical course. Here, we report a case of a 59-year-old woman with B-ALL carrying a complex karyotype with trisomy 5 (+5) and monosomy 20 (-20) in addition to the classical Ph chromosome. This report summarizes the clinical presentation, hematological and immunophenotypic features, extensive cytogenetic and molecular diagnosis, treatment regimen, and prognostic significance. The coexistence of other chromosomal abnormalities most probably reflects clonal evolution and is associated with a worse prognosis, emphasizing the importance of tailored therapy including tyrosine kinase inhibitors and strict molecular follow-up.
Background: Medical imaging procedures involving ionizing radiation are widely used for diagnosis and management, but they carry potential health risks if not properly understood and managed. Aim: To assess the knowledge and awareness of radiation exposure and safety practices among patients undergoing medical imaging. Methods: A hospital-based cross-sectional study was conducted among 150 patients using a structured questionnaire. Data were analyzed using SPSS, and associations were tested using the Chi-square test with p < 0.05 considered significant. Results: Only 29.3% of patients had good knowledge, while 42.0% and 28.7% had moderate and poor knowledge respectively. Awareness regarding CT radiation was 65.3%, while only 38.0% were aware of X-ray exposure and 32.7% knew about cancer risk. Significant association was found between education and knowledge (p = 0.002). Awareness of safety practices such as lead apron use (48.0%) and dose minimization (36.0%) was limited. Conclusion: Knowledge and awareness of radiation exposure and safety practices among patients are inadequate, highlighting the need for improved education and communication strategies in healthcare settings
Severe Plasmodium falciparum malaria is associated with life-threatening complications due to widespread microvascular dysfunction and multiorgan involvement. While cerebral malaria, acute kidney injury, and acute lung injury are recognized complications, rare manifestations such as peripheral gangrene and subarachnoid hemorrhage are seldom reported. We report the case of a 60-year-old female from rural India who presented with high-grade fever, chills, and respiratory distress. Laboratory evaluation confirmed P. falciparum malaria with severe parasitemia. Her clinical course was complicated by acute lung injury, generalized seizures, subarachnoid hemorrhage, acute kidney injury, coagulopathy, and evolving peripheral gangrene. She required intensive care support, intravenous artesunate, ventilatory assistance, anticonvulsants, and transfusions. Despite developing dry gangrene necessitating partial amputation of fingers, the patient improved with aggressive management and was discharged in stable condition. This case highlights the potential for P. falciparum malaria to cause rare and severe complications, including asymmetrical peripheral gangrene and subarachnoid hemorrhage. Early recognition of atypical manifestations, multidisciplinary care, and timely intervention are crucial for improving survival and reducing morbidity in severe malaria.
