Himalayan University, Itanagar, Arunachal Pradesh, India, is a non-profit university recognized by University Grant Commission, Government of India under section of 2f of UGC act 1956. The university was established to develop and uplift the economy through higher education to raise the literacy rate that make up especially North Eastern part of India as well as all other parts of India. The University is accredited and recognized by All India Council for Technical Education (AICTE), Pharmacy Council of India (P.C.I), Bar Council of India (B.C.I), Rehabilitation Council of India (R.C.I) and is also a member of AIU, AIMA, CII.
The brain is one of the most delicate protected organs of the human body. The circulation of blood to the brain is secured by the blood–brain barrier (BBB), blood-cerebrospinal fluid barrier (BCSFB), and cerebrospinal fluid-brain barrier (CBB). These barriers also restrict the distribution of therapeutics to the central nervous system (CNS) for the treatment of any psychotic disorder. Oral parenteral routes are the main routes for the delivery of anti-psychotics to the brain. Still, associated drawbacks include the stomach's acidic pH, first-pass metabolism, enzymatic degradation, plasma protein binding and finally, the barriers of brain. One of the novel routes for directly targeting the drug to the brain is the intranasal route, which bypasses the BBB. The drug is delivered to the brain via the olfactory trigeminal nerve regions located in the septum ceiling of the nasal cavity, reaching the brain more quickly and at higher concentrations than viat the systemic circulation or other tissues. In most cases, nasal doses are 2–10 times less than the oral dose. Nanoemulsions (NE) are bi-phasic dosage forms of two immiscible liquids stabilized by surfactants having a mean droplet size of 100-300 nm. NE is attracting increasing interest in nose-to-brain delivery (N2B) due to its ability to address issues related to drug solubility drug stability. The smaller droplet size of NE provides a larger surface area, thereby increasing the dissolution rate according to the Noyes-Whitney equation.
Pigeonpea (Cajanus cajan L. Millsp.) is an important legume crop worldwide. However, its productivity is severely constrained by insect pests, particularly Helicoverpa armigera, which damages flowers and pods, leading to significant yield losses. To develop eco-friendly pest management strategies, six bacterial strains (A–F) were isolated from naturally dead larvae, and their protein extracts were evaluated for effects on larval growth and mortality. Protein from strain B caused the highest mortality (68.75
In recent pasts, HFE-7100 finds its industrial applications like cleaning electronic equipment, secondary refrigerant and carrier fluids for lubricant. Detailed theoretical investigations have been carried out on the mechanism, kinetics and thermochemistry of the gas-phase reactions between CF3CF2CF2CF2OCH3 (HFE-7100) and HO2 and NH2 radicals using DFT-based M06-2X/6-311++G(d,p) level of theory. Two important H abstraction channels have been identified and one transition state has been located for each reaction channel. The pre-reactive and post-reactive complexes are validated at entrance and exit channels, respectively. The potential energy surface of the HFE-7100 with HO2 and NH2 radicals has been investigated using DFT method. The rate constants of the two reactions are computed over the temperature range of 250–450 K for the first time. Our results suggest that hydrogen abstraction by NH2 radical is likely the dominant route for the atmospheric oxidation of HFE-7100 under reaction conditions. Keywords: Segregated HFE; M06-2X; DFT; Rate constant; Amino radical
In the present study the investigation on the geographical processes responsible for the formation of monazite placer deposits in the southern coastal region of Kerala were carried out. The sand samples were collected from the southern coastal environment of Kerala. The activity concentration of natural radionuclides viz. 40 K, 226 Ra and 232 Th in the collected sand samples were measured using high efficiency 3"×3" NaI (Tl) detector. The radiological parameters were measured and compared with the Indian and World average values. The results show that the activity concentration of natural radionuclides in the collected sand samples was much higher than the values reported in other regions in the World. The enhanced level of natural radioactivity is due to the monazite bearing black sand present in the study area. The geographical processes are the key deciding factor in the distribution of monazite rich black sand in the southern coastal regions of Kerala. The results of the present investigation are discussed detail in the manuscript.
