All Poly (AP) tibial unicompartmental knee arthroplasty (UKA) seems to have advantages in comparison with metal-based (MB) UKA, such as greater polyethylene thickness, wear resistance, bone stock preservation and lower implant costs. The objective of this retrospective study was to evaluate the short-term clinical-functional and radiographic results, complications and survivorship of AP UKA performed consecutively with a minimum follow-up of 2 years. Retrospective cohort analysis all consecutive knees operated with medial and lateral AP UKAs, including bilateral cases, with a minimum follow-up of 2 years. Demographic data were analyzed at the patient level and clinical-functional results were assessed per knee using the KSS, KOOS and VAS scales. Radiographically, mechanical axis (HKA) correction and the presence of radiolucency > 2mm were evaluated. Complications incidence and prosthetic survivorship was determined. Pre-postoperative comparisons were performed using linear mixed-effects models with random intercept per patient to account for the non-independence of bilateral cases. Subgroup analyses involving fewer than 10 observations were considered exploratory and no formal statistical inference is drawn. A value of p < 0.05 was considered statistically significant with a confidence interval (CI) 95
To evaluate the effectiveness and safety of personalized embryo transfer (pET) guided by TERTs compared with standard embryo transfer (sET) in assisted reproductive technology. Systematic review and meta-analysis of randomized controlled trials (RCTs) and cohort studies (CS) at low or moderate risk of bias was conducted. PubMed/MEDLINE, EMBASE, CENTRAL, LILACS, and CINAHL were searched to November 2025 without restrictions. Conference abstracts and reference lists were also screened. Reviewers independently screened, extracted data, and assessed risk of bias. RCTs and CS were pooled separately using random-effects models. Odds ratios (ORs) were synthesized using the generic inverse-variance method. Prespecified subgroups included prior failures and euploid transfers. We included 44 studies (4 RCTs; 40 CS). Thirty-five studies evaluated ERA, six rsERT, and four other platforms. In women with limited or no prior failures, two low-risk RCTs showed pET with ERA probably results in little or no difference in LBR versus sET (RR 0.98, 95
Study and assess the differences in the prognostic factors in pregnancy associated breast cancer by assisted technical reproduction and without . Study 164 pregnancy associated breast cancer, 124 without assisted technical reproduction and 40 with assisted technical reproduction, treated in the same hospital. Analyze prognostic factors: estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 , histological grade and ki67, of pregnancy associated breast cancer with and without assisted technical reproduction. Patients with pregnancy associated breast cancer without assisted technical reproductio: estrogen receptor is positive in 91 (73’38 %), negative in 33 (26’61 %) patients with assisted technical reproduction ,estrogen receptor is positive in 34 (94’44 %), negative in 2 (5’55%) patients. (p<0’05), ki67 <20 in 50 (46’72%) patients and > 20 in 57 (53’27%) patients without assisted technical reproduction, and ki67 < 20 in 19 (67’85 %) patients, and Ki 67 >20 in 9 (32’14%) patients with assisted technical reproduction (p<0’05). Progesterone receptor and HER2 receptor there was no difference between with and without assisted tecnical reproduction. (p=ns). Pregnancy associated breast cancer by assisted technical reproduction influence estrogen receptor and Ki67, and do not influence progesterone receptor and HER2 receptor M. Izquierdo, S. Baulies, M. Gallardo, C. Ara, F. Fargas, F. Tresserra, R. Fabregas, P. Barri S. Prognostic factor pregnancy associated breast cancer by assisted technical reproduction [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS5-10-09
BACKGROUND:Chronic postsurgical pain (CPSP) following caesarean delivery remains poorly studied despite being one of the most common surgeries and its potential devastating consequences on patients and their newborn babies. We conducted a prospective evaluation of data from a large multicentric cohort to calculate its prevalence, describe its characteristics, risk factors associated and measure its consequences on patients' quality of life and daily functioning. METHODS:A prospective multicentre observational study with women undergoing elective caesarean section. All participants were contacted at 3 months postoperatively to assess the presence or absence of persistent pain. Pain patients were assessed in person to collect data from a focused clinical interview, a targeted physical exam and a set of comprehensive quality of life and functional questionnaires. RESULTS:CPSP was diagnosed in 69 women (14.59%) of the 514 total participants. Most (94.20%) described their pain with somatic-like characteristics. 46.38% also screened positive for neuropathic features and 41.51% fulfilled diagnostic criteria for chronic pelvic pain. Preoperative SF-12 and catastrophic scale and worse postoperative pain at 24 h were related to a higher risk of developing CPSP. Patients with CPSP reported moderate interference in mood, general activity and occupational functioning being more severe in patients with neuropathic pain. CONCLUSIONS:The prevalence of persistent pain after caesarean delivery is noticeably high for such a common, simple and benign surgical procedure. A subset of patients develops mixed neuropathic pain and chronic pelvic pain syndromes. CPSP causes a significant negative impact on quality of life, particularly among patients with neuropathic symptoms. SIGNIFICANCE STATEMENT:This manuscript presents the analysis of the results of a multicentre study regarding the prevalence of CPSP after a caesarean section. Moreover, we have also looked for clinical characteristics of CPSP and its effects on quality of life and daily functioning. The study we describe provides new insights about which the incidence, type, location of CPSP after a caesarean section and association with chronic pelvic pain. It also shows the impact that having CPSP has on these patients' quality of life and activities of daily living.
