Krishna Institute of Medical Sciences is located in Karad, Maharashtra, The green, eco-friendly campus is spread over 57 acres and is well connected by rail, road & air.The University is accredited by NAAC 'A+' grade and has been conferred with ISO 9001 : 2015 certification. The constituent faculties of the University include Medical, Dental, Physiotherapy, Nursing, Pharmacy and Biotechnology offering undergraduate and postgraduate courses in the respective faculties. It also runs Ph.D. programs and Post Doctoral Fellowships in various subjects.The medical college is about 35 years old and is recognized by the Medical Council of India, Medical Council of Malaysia and is listed in the WHO's World Directory of Medical Schools. MBBS and postgraduate degree/diploma courses in clinical and basic sciences in 17 disciplines are recognized by Medical Council of India. It also admits the international students from all over the globe for undergraduate courses.It has state-of-the-art museums with large collection of specimens and models. The KIMS diagnostic laboratory has been accredited by National Accreditation Board for Testing and Calibration Laboratories (NABL). The Lead Referral Laboratory is the first of its kind in Maharashtra state, which was ranked the first amongst 40 such centres in India. The well equipped Molecular & Human Genetics Laboratory is a feather in the cap.The teaching hospital KH&MRC (Krishna Hospital and Medical Research Centre) is recognised by National Accreditation Board for Hospitals & Healthcare Providers (NABH).The teaching hospital is 1125 bedded multispecialty tertiary care hospital with facilities for Critical Care, Endoscopic Surgeries, Dialysis, Cardiology, Cardio-vascular-thoracic-surgery, Oncology, Urology, Neurosurgery, Plastic surgery, Oral and Maxillofacial Surgery and a recognized Renal Transplant Unit. It has fully equipped major operation theaters, minor theaters, labour rooms, blood bank accredited by NABH, radiodiagnosis and radiotherapy, computerized medical records, counseling services etc. There are separate intensive care units like Medical, Surgical, Coronary care, Pediatric, Neonatal (accredited by Neonatology Forum of India), Respiratory and Obstetrics. The neonatal ICU is recognized by Neonatology Forum of India. The radio-diagnosis department has facilities for MRI, color doppler, mammography, DSA etc. It also actively participates in national healthcare programs and various extensions and outreach community programs initiated by the institute.The University has been ranked 5th amongst the cleanest higher Educational Institutions in the category of 'Technical Institutions - Universities (Residential)' in the year 2018. The University has also received certificate for 'Maintaining, Promoting and Encouraging the Culture of Swachhta in Higher Education Institutions in the country'.Experienced faculty, secure and spacious hostels, a sports complex, various extra-curricular activities have succeeded in attracting the students from all over India and from USA, UK, New Zealand, Middle East countries, Sri Lanka, Canada, Mauritius and many other countries.
Background VEXAS syndrome is a recently recognized, acquired monogenic adult onset hemato-inflammatory syndrome characterized by somatic mutations within the UBA1 gene. The acronym VEXAS stands for vacuoles, E1 enzyme, X-linked inheritance, autoinflammatory tendencies, and somatic mutations. It presents as a severe progressive disease displaying varied characteristics that bridge hematologic and rheumatologic domains. Herein, we describe a series with a detailed evaluation of 11 cases of VEXAS syndrome. Materials and methods A comprehensive retrospective analysis of patients diagnosed with VEXAS syndrome over the last 5 years (2020-2025) was conducted. Data on clinical presentation, histopathological findings, genetic characteristics, and outcomes were recorded for systematic characterization. Results A total of 11 cases of VEXAS syndrome were identified. All the patients were males with an age range from 42 to 77 years. Prominent clinical characteristics included history of fever (11), arthritis/arthralgia (10), inflammatory skin lesions (7), vasculitis (6), ocular inflammatory conditions (6), relapsing polychondritis (6), unprovoked venous thrombosis (5), and auricular chondritis (4). Persistent unexplained cytopenia was present in all the patients, manifesting as anemia (10, 8 of which were macrocytic), thrombocytopenia (4), and neutropenia (2). Bone marrow examination was performed in nine cases, five showed morphologic dysplasia. Furthermore, all nine cases characteristically showed cytoplasmic vacuolations in hematopoietic precursors. UBA1 somatic mutations included p.Met41Thr (c.122 T>C Exon 3) (55%), p.Met41Val (c.121 A>G Exon 3) (27%), p.Met41Leu (c.121 A>C Exon 3) (9%), and a variant in the acceptor splice site of Exon 3 (c.118 G>C) (9%). p.Met41Val is associated with inferior overall survival (OS). Conclusion This study characterizes the clinical, morphologic, and laboratory features of VEXAS syndrome and presents the first comprehensive patient cohort from India. With a complex and heterogeneous clinical profile, awareness of the disease is particularly essential among hematologists, rheumatologists, and dermatologists for accurate diagnosis and management.
Near-Peer-Assisted Teaching (NPAT) is an innovative instructional approach in which senior students facilitate learning among their junior peers in a structured and supportive environment. This study evaluated the effectiveness of NPAT in improving basic clinical skills among undergraduate medical students at a rural tertiary care teaching institution. A study with a quasi-experimental design was conducted at a rural tertiary care teaching institution in Maharashtra, India, wherein Phase III MBBS students were divided into an intervention group receiving NPAT and a control group undergoing conventional faculty-led teaching. Trained senior students conducted sessions on temperature, pulse, respiratory rate, and blood pressure measurement. Clinical competence was assessed using Objective Structured Clinical Examination (OSCE) scores. Out of 80 Phase III, Part 1 MBBS students included in the study, the ones exposed to NPAT (n = 40) demonstrated significantly higher mean OSCE scores and greater attainment of expected competency levels across all skills: temperature [8.97 (0.99) vs. 5.20 (2.10)], pulse rate [7.07 (1.02) vs. 5.12 (1.74)], respiratory rate [6.45 (0.67) vs. 4.49 (1.58)], and blood pressure measurement [13.85 (1.20) vs. 8.02 (2.61)]; P < 0.001 for all comparisons with controls (n = 40). Attendance and engagement were also better in the NPAT group as compared to control group, respectively (88
Nutrition plays a fundamental role in maintaining human health and modulating disease risk across the life course. This narrative review synthesizes contemporary evidence on the clinical significance of macronutrients, including carbohydrates, proteins, and fats, and micronutrients, including vitamins and minerals, establishing nutritional balance as a central determinant of human health, disease susceptibility, and therapeutic efficacy. These nutrient categories function within an integrated metabolic network in which macronutrients provide energy and structural substrates, while micronutrients serve as essential cofactors and regulatory agents in enzymatic, hormonal, and cellular signalling processes. The synthesis demonstrates that nutritional imbalance, arising from either deficiency, such as iron-deficiency anaemia and vitamin D insufficiency, or excess, including high intakes of refined carbohydrates and saturated fats, constitutes a major contributor to global disease burden, particularly the phenomenon described as the double burden of malnutrition. In response to these challenges, the review highlights the role of evidence-based nutritional therapy, encompassing established dietary patterns such as the Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets, as well as the clinical implementation of medical nutrition therapy in chronic disease management. It further emphasizes a paradigmatic shift from population-level dietary recommendations toward precision nutrition, an emerging framework that integrates nutrigenomics, metabolomics, and gut microbiome profiling to inform personalized dietary interventions. By conceptualizing nutrition as a dynamic and interactive system, this review offers a comprehensive perspective that integrates biochemical mechanisms with individualized clinical care, positioning nutritional balance as a foundational component of contemporary preventive and therapeutic medicine.
BackgroundEndometrial carcinoma is a common gynecological malignancy with rising incidence rates. While histopathological staging remains a cornerstone for treatment decisions, its limitations in addressing tumor heterogeneity and molecular complexity have led to the incorporation of molecular subtypes in recent endometrial carcinoma guidelines.ObjectiveTo assess global practice patterns regarding the adoption of genomic profiling, molecular classification, and morphological assessment in endometrial carcinoma, with a focus on recent updates to the International Federation of Gynecology and Obstetrics staging system.MethodsA survey of 68 gynecologic pathologists from Asia, North America, and Europe was conducted, collecting data on their use of morphologic assessments, ancillary immunohistochemical (IHC) tests, and molecular characterization.ResultsOur study indicated significant regional variations, with North American and European pathologists more likely to adopt molecular testing, such as mismatch repair (MMR) and p53 IHC, than their Asian counterparts. Despite the growing recognition of molecular subtypes, many pathologists continue to rely on traditional methods, and barriers such as resource limitations and a lack of standardized protocols hinder widespread molecular testing.ConclusionOur results suggest a need for more uniform adoption of updated guidelines to improve endometrial carcinoma staging accuracy and patient outcomes. Further research and standardized protocols are necessary to ensure the effective and consistent application of molecular biomarkers in clinical practice.
Lateral ventricular tumors are rare intracranial lesions, accounting for approximately 1–1.3
