The article is devoted to a little-studied aspect of the history of the fishing industry in the North. The history of record-keeping historical sources related to the fishing industry does not relate to the developed topic. By studying this type of historical sources, it is possible to reliably establish a fairly broad aspect of historical facts: the full name of a particular historical person (captain), the exact name of the vessel, the ship's affiliation to a particular port, and socio-economic aspects of a particular era.
BACKGROUND: Ankle joint and foot injuries are the most common type of musculoskeletal trauma in children. Their mechanism of injury mainly determines the pattern of damage. AIM: To optimize the diagnosis and treatment of inversion injuries of the ankle joint and foot in children and assess their association with sports participation and comorbidities. METHODS: Outpatient medical records of patients treated at the consultative and diagnostic department between 2014 and 2023 were analyzed. Overall, 1518 cases involving ankle joint and foot injuries were determined, including 111 patients referred with a preliminary diagnosis of sprain and an inversion injury mechanism. RESULTS: The study included boys and girls aged 10–16 years, one-third of them participated in sports, primarily team and gymnastic disciplines. Recurrent inversion injuries occurred more often in children who participated in sports, which should be considered when planning training programs and return to sport. Analysis of the incidence of injuries associated with inversion trauma showed that ligament sprains were most common in nonathlete children (39%), whereas bone fractures predominated in children who participated in sports (38%). CONCLUSION: This study revealed a high incidence of bone and ligament injuries associated with inversion trauma in children and elucidated the contribution of sports participation to these injuries. The broader use of magnetic resonance imaging and ultrasound, along with the refinement and standardization of their protocols, improves the understanding of inversion injuries of the foot and facilitates development of more effective diagnostic and treatment algorithms.
Purpose: To evaluate the proportion of BRCA1 / 2 mutations in patients with serous and endometrioid cancer of the ovary, fallopian tube, and peritoneum in Russia, to evaluate the percentage of germinal and somatic mutations, to identify the spectrum of mutations in BRCA1 / 2 genes, to evaluate clinical and morphological features of the BRCA-associated ovarian cancer (OC).Patients and methods: The study enrolled patients of 18 years and older with newly diagnosed serous and endometrioid cancer of the ovary, fallopian tube, and peritoneum. Biological material (blood, tumor tissue) was collected, followed by molecular genetic analysis. The method of mutations detecting in the blood were: allele-specific PCR, high-resolution melting (HRM), Sanger sequencing method. Advanced genetic testing included the use of generation sequencing (NGS) and multiplex amplification of ligated probes (MLPA). The collection of clinical data, family history, clinical and morphological characteristics of the tumor was performed.Results: 500 patients were included in the study, the evaluation of BRCA1 / 2 mutations was performed in 496 patients (99,2 %). The frequency of BRCA1 / 2 mutations in the Russian patient population was 28,4 % (n = 141 / 496). The incidence of germinal mutations was 23,5 % (n = 117 / 141), and somatic — 4,8 % (n = 24 / 141). Frequent mutations in the Russian population were identified in 50 % of cases. When analyzing the ethnicity of patients in the Russian Federation BRCA-associated OC was most common in Russian (83,6 %, n = 118 / 141), Ukrainian (4,2 %, n = 6 / 141) and Tatar (3,5 %, n = 5 / 141) women. A family history of cancer was detected in 44 % of patients (n = 62 / 141) with BRCA1 / 2 mutations.Conclusions: Due to the high frequency of germinal and somatic BRCA1 / 2 mutations in the Russian patients it is recommended to conduct the advanced testing methods not only in blood samples but also in tumor tissue.
Gastric and colorectal cancer models are essential for the advancement of precision medicine discovery and development. 2D attached monolayer, spheroid and organoid approaches have all been used in the formation of biobanks containing primary patient-derived cells. Here, we report an assessment of those procedures for a panel of nine patient-derived adenocarcinoma samples, along with the most applicable method for the bio-banking of these cell types. A live cell biobank of tumour specimens would facilitate drug discovery laboratories to evaluate drugs on the population of cell cultures, prior to the clinical phase.
BACKGROUND: A flatfoot is the most common condition in the practice of a pediatric orthopedist. A flatfoot is primarily diagnosed based on the assessment of the degree of the foot flattening. Along with clinical examination, footprint analysis is often used in practice due to the safety of this study and convenience and ease of implementation. AIM: This study aimed to determine how much footprints can correlate with the clinical assessment of flatfoot in children and which footprint indices are the most valuable in flatfoot assessment. MATERIALS AND METHODS: The study included the survey results of 76 children aged 715 years of the St. Petersburg 49th school School of Health for 20212022. In this study, anthropometric data, clinical parameters (value of the heel valgus, arch angle, and Friedland index) and footprint indices and angles (Schwartz and Clarke angle, ChippauxSmirak index, Staheli index, Cavanagh and Rodgers index, and Irwin index) were analyzed. In the study, the average values were calculated, and correlation and regression analyses were performed. RESULTS: The footprint parameters did not have moderate and strong correlations with clinical parameters. Footprint parameters that assessed the area of the barefoot zone on the footprints (Irwin index and Cavanagh and Rodgers index) showed statistically significant moderate and strong correlations among plantographic parameters. Among linear and angular footprint parameters, the ChippauxSmirak index showed statistically significant moderate and strong correlations. CONCLUSIONS: The footprint criteria weakly correlated with the foot shape criteria in a clinical assessment, which does not allow us to interpolate the footprints data to the clinical evaluation data of the foot. The Cavanagh and Rodgers index, Irwin index, and ChippauxSmirak index had statistically significant moderate and strong correlations with other indices, which makes them more valuable in the assessment of feet according to the footprint analysis.
