The Instituto Nacional de Engenharia, Tecnologia e Inovação (National Institute of Engineering, Technology and Innovation), usually known as INETI for short, was a state-run R&D institution in Lisbon, Portugal, with scientific and technological activities in areas like new systems, processes and products; environmental and sustainable management; geological resources and risks; citizen protection, health and safety; space and defence; laboratory support and testing; etc.In 2007 it was merged into the Laboratório Nacional de Energia e Geologia.The Instituto Nacional de Engenharia, Tecnologia e Inovação (National Institute for Engineering, Technology and Innovation) carries out research, testing and technological development. Its mission is to promote technological innovation focused on science and technology with the overriding objective of raising company competitiveness within a framework of sustainable economic progress.Within the scope of competences attributed by Portuguese government strategies and policies for economic and social development, INETI takes up the role of an interface between the results generated by research and development programmes and their technological integration into the private sector (including companies, and other organizations).Its participation in a range of international projects positions it both as a key partner for internationalisation and a source of specialist information across its respective fields.INETI, as a Portuguese Ministry of Economy and Innovation entity, further serves as consultant for public policies in a diverse range of fields including: energy, the environment, sustainability, metrology, norms and certification.
Medicinal plants have been an inspiration source for developing new chemical entities, providing diverse chemical structures and modes of action for medicinal chemistry strategies. Modern medicinal chemistry approaches promote functional group changes to improve NCE’s biological activity. Incorporating the trifluoromethyl (-CF3) group into organic compounds is crucial in modern drug design. It may affect the compound's lipophilicity, solubility, stability, molecular conformation, and pKa, changes that may lead to the discovery of new medicines to treat diseases of our times. For this reason, this chemical transformation is currently a hot topic in the organic chemistry field. Chemists are competing to develop better methods to carry out this transformation efficiently, less hazardously, and cost-effectively. The high number of annual scientific publications on trifluoromethylation evidences the competition. This review profiles 21 trifluoromethylated New Chemical Entities (NCE) selected in December 2020 from the GlobalData database, mainly in late stages of clinical trials (Phase II and III) or already in the commercial phase, containing one or two -CF3 groups in para or meta positions of benzene, or a pyridine ring. Synthetic approaches, therapeutic applications, and manufacturing industrial challenges are provided.
This paper presents a novel multi-variable high-order sliding mode quasi-optimal control method for unmanned helicopters. In order to facilitate the theoretical design and engineering implementation, the control system is divided into attitude and position subsystem, and the latter is further subdivided into two parts, horizontal and vertical position control. Then the multi-variable adaptive high-order continuous sliding mode controllers are designed for attitude and position, respectively, based on integral sliding mode surface. A new quadratic performance index is proposed in the design process, which enables the control system to converge in finite time, and the convergence rate can be adjusted by control parameters. Finally, the effectiveness and robustness of the proposed method are verified and compared with existing literature by simulation and practical experiments. The comparison results show that the proposed method has higher tracking accuracy and better robustness.
A previsao do vento com exactidao e actualmente uma ferramenta necessario para a analise do potencial e estimativa de producao de energia eolica. Apesar do progresso significativo nos modelos de previsao meteorologica, os modelos apresentam erros sistematicos que podem ser corrigidos com a aplicacao de modelos estatisticos, lineares ou nao, a partir das estatisticas acumuladas de um certo modelo de previsao. Esses modelos correctivos tem o nome generico de MOS (Model Output Statistics) que tem como base o uso de regressoes multilineares. Neste estudo, realizaramse previsoes MOS para as 24, 48 e 72 horas, para as componentes horizontais do vento, assim como, para o prazo de previsao de 36 horas, nas 61 estacoes da rede do Instituto de Meteorologia Portugues. Os resultados mostram uma melhoria do erro medio quadratico na ordem de 80% na previsao, sendo menos significativa com o aumento do prazo de previsao.
Com o acentuado desenvolvimento da capacidade de producao de energia eolica onshore, onde Portugal ja excede, actualmente, 3500 MW de capacidade instalada, e de esperar que este numero ascenda a patamares muito elevados, tendo em conta os objectivos ambiciosos que a Uniao Europeia planeia para o sector ate 2020, prevendo-se que, em 2013, Portugal atinja a meta dos 5100M de capacidade instalada. No entanto, o recurso eolico onshore nacional nao e infinito, tendo o LNEG ja estimado uma meta nacional para a capacidade eolica sustentavel onshore para Portugal Continental de, aproximadamente, 6000MW [1], capacidade so ultrapassavel com a libertacao de regiao actualmente protegidas ambientalmente de forma severa, bem como com a introducao de impactos nao desprezaveis sobre as populacoes, que seria desejavel evitar. Desta forma, e para um horizonte temporal alem de 2013, ha que fomentar e redireccionar as oportunidades de investimento do sector para outro nicho de mercado que se espera emergente, e que e o aproveitamento da energia eolica offshore que o Pais dispoe [2].
O estudo da deformabilidade de argamassas de revestimento e essencial para a minimizacao de uma das anomalias mais frequentes nas fachadas de edificios: o aparecimento e a propagacao de fissuras. Estas fissuras ocorrem devido a tensoes internas na argamassa de revestimento, em consequencia de deslocamentos impostos pela estrutura de suporte subjacente. Os estudos de deformabilidade devem incluir um ou mais metodos experimentais para a determinacao do modulo de elasticidade ( E ) das argamassas de revestimento em questao. Neste artigo apresenta-se uma campanha de ensaios experimentais realizados para determinar o E dinâmico de varias composicoes de argamassas de cimento, cal hidraulica e cal aerea, utilizando tres metodos experimentais. Os resultados obtidos foram comparados entre si por forma a verificar a qualidade e a fiabilidade de cada metodo experimental.
