Pratap Chandra Memorial Homoeopathic Hospital & College (PCMHHC) is the Homoeopathic medical college and hospital in Kolkata, West Bengal. The college was established in 1926 by the late Dr. Jitendra Nath Majumder, in order to commemorate the name of his illustrious father, the late Dr. Pratap Chandra Majumder, who was one of the pioneers of Homoeopathy in India and popularised Homoeopathy in West Bengal. It is the second oldest Homeopathic Institution in India as well Asia..
In modern era, elevated serum prolactin level is commonly documented in the patient with polycystic ovaries due to sedentary lifestyle. Both pathologies are characterized by several common clinical features like amenorrhoea, galactorrhea, hirsutism, infertility etc. In conventional system, these cases are commonly treated by dopamine antagonistic, whereas homoeopathy offers a holistic approach to treat the cases based on individualization. Here we have presented a case of hyperprolactinaemia along with bilateral PCOS with the complaint of irregular delayed menses for the last 8 years is presented here. There was significant reduction of high serum prolactin level (baseline vs. 3month) as well as improvement in quality of life (QoL) by score of PCOSQOL scale; after prescribing Pulsatilla 0/1 dose according to the totality of symptoms. Thus this case report presented here possible benefit of the indivualized homoeopathic medicine in the treatment of Hyperprolactinaemia along with PCOS within a very short period, without any adverse effect.
Chimeric antigen receptor CAR-T therapy is a rowing therapeutic approach in hematological malignancies and certain solid tumors. Despite this success, many obstacles and challenges were approaching the therapeutic limit towards the efficacy of CAR-T therapy. Here, we discuss such challenges and approaches to overcome those. Recently, after the success of clinical trials, the F.D.A. approved certain drugs to treat diseases like acute lymphocytic leukemia (ALL), lymphomas, and myeloma with significant success rates. While a considerable number of clinical studies are ongoing for hematological malignancies, research is developing to translate the feasibility of CAR T therapy in solid tumors. CD19 and BCMA are the most common targets in CAR-T therapy. Numerous other approaches have been explored, including novel therapeutic strategies. However, various toxicity and adverse events identified hold the path to success. These include cytokine release syndrome (C.R.S.), CAR T-cell-related encephalopathy syndrome (CRES), infections, and cytopenia. In this review, we focus on the present therapeutic targets and obstacles and probable solutions for future direction.
Sub-acute appendicitis is a condition where some episodes of acute appendicitis apparently subside spontaneously before they reach the acute stage. A 29-year-old man presented with pain in the right iliac fossa for the last 1 week with periumbilical radiation of pain associated with continual nausea, occasional bouts of vomiting, chill and rigours. Computed tomography scan report suggested a case of sub-acute appendicitis. On the basis of presenting features, the patient was treated with Belladonna and Calcarea carbonica in 30c and 200c (centesimal) potencies, respectively, with repetitions. The patient was under treatment for nearly 6 months with favourable improvement of the generalities along with the underlying pathology. The case was indicative of further studies with adequate sample size in such pathological condition to come to any decisive conclusion.
Abstract Objectives Homeopathic treatment is claimed to be beneficial for primary dysmenorrhoea (PD); still, systematic research evidences remain compromised. This study was undertaken to examine the efficacy of individualized homeopathic medicines (IH) against placebo in the treatment of PD. Methods A double-blind, randomized, placebo-controlled trial was conducted at the gynecology outpatient department of Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, West Bengal, India. Patients were randomized to receive either IH (n=64) or identical-looking placebo (n=64). Primary and secondary outcome measures were 0–10 numeric rating scales (NRS) measuring intensity of pain of dysmenorrhea and verbal multidimensional scoring system (VMSS) respectively; all measured at baseline, and every month, up to 3 months. Group differences and effect sizes (Cohen’s d) were calculated on intention-to-treat (ITT) sample. Results Groups were comparable at baseline (all p>0.05). Attrition rate was 10.9% (IH: 7, placebo: 7). Differences between groups in both pain NRS and VMSS favoured IH over placebo at all time points (all p<0.001, unpaired t-tests and two-ways repeated measures analysis of variance) with medium to large effect sizes. Natrum muriaticum and Pulsatilla nigricans (n=20 each; 15.6%) were the most frequently prescribed medicines. No harms, serious adverse events and intercurrent illnesses were recorded in either of the groups. Conclusions Homeopathic medicines acted significantly better than placebo in the treatment of PD. Independent replication is warranted. Trial registration: CTRI/2018/10/016013.
Introduction: Ganglion cysts are soft tissue swellings occurring most commonly in the hand or wrist. Studies have reported 8%–50% of them resolve spontaneously in adults within 2 years approximately. Cases Summary: We present three cases of wrist ganglion treated successfully with individualized homoeopathic medicines; the results were evident within few weeks. Individual curative response of a homoeopathic medicine in each case was assessed through Modified Naranjo Criteria for Homoeopathy-Causal Attribution Inventory, which further elucidated role of constitutional treatment in homoeopathy.
