National Institute of Homoeopathy

Background:Gastric ulceration is a major global health issue, and conventional anti-ulcer drugs often cause adverse effects, necessitating safer alternatives. Ornithogalum umbellatum (OrUm), traditionally referenced in homeopathy for gastrointestinal complaints, lacks thorough pre-clinical evaluation. This study investigated the anti-ulcer effects of OrUm in mother tincture (MT), 6C and 30C potencies using an indomethacin-induced gastric ulcer model in Sprague-Dawley rats. Methods:Thirty-six rats were divided into six groups (n = 6 per group). Five groups received indomethacin (30 mg/kg, subcutaneously) to induce ulcers. Four of these were treated orally for 7 days with esomeprazole (20 mg/kg), OrUm-MT, OrUm-6C, or OrUm-30C. One group served as disease control and another as normal control. Biochemical parameters (including SGOT, SGPT, ALP, urea, creatinine, glucose, protein), antioxidant markers (MDA, SOD) and histopathological changes were assessed. Liquid chromatography-mass spectrometry (LC-MS) was performed to analyze the phytochemical composition of OrUm-MT. Results:OrUm-6C significantly improved SGOT, SGPT, ALP, urea, glucose, protein and MDA levels (p < 0.05), with histological evidence of mucosal healing. OrUm-MT significantly reduced SGPT and creatinine levels but showed mild ulceration histologically. OrUm-30C showed no significant biochemical improvement. LC-MS analysis of OrUm-MT revealed phenolic acids and flavonoids, which may underlie its antioxidant effects. Conclusion:This is the first pre-clinical study to demonstrate the anti-ulcer potential of OrUm. Among the tested potencies, OrUm-6C showed the most consistent biochemical and histopathological improvements. These findings support further investigation through rigorous pre-clinical and clinical studies to establish its therapeutic potential.

Background: Alopecia areata (AA) is an autoimmune disease characterised by hair loss in patches from one or more areas of skin. While it can affect the scalp, it may occur in other parts of the body as well. No age group is predominantly affected. Objective: This case series evaluates the effects of individualised homoeopathic treatment in patients with AA. Method: A total of 5 cases are included in this study. AA was diagnosed based on presentation of clinical symptoms. Two patients improved with Phosphorus. Another two were prescribed Natrium muriaticum and Typhoidinum respectively. One patient improved with Tuberculinum when indicated remedy Natrium muriaticum did not improve the case despite indications. Medicines in all cases and their follow-ups were prescribed based on clinical signs, totality of symptoms, individualisation and miasmatic analysis of the patient. Result: The improvement was assessed clinically based on symptom reduction and growth of new hairs. Both the patients improved clinically, and new hair growth was seen. This case series provides evidence that individualised homoeopathic treatment is effective in AA cases. Modified Naranjo Criteria for Homeopathy (MONARCH) was used to assess the causal attribution between the medicine prescribed and the treatment outcome. Conclusion: Individualised homoeopathic medicines are useful in treatment of AA.

Background Polyendocrine Metabolic Ovarian Syndrome is an endocrine and reproductive disorder affecting 7 to 15% of women of reproductive age. PMOS is the first cause of anovulatory infertility nowadays and infertility is found in 70 to 80% of affected women. Currently, the most preferred and better serving regimen of PMOS is opting for allopathic medicines; however, considering the side effects, there is a demand for a complementary therapy. Constitutional Homoeopathic medicine acts on psychic, somatic and pathological levels providing holistic approach to cure diseases. Case Report A 19-year-old woman presented to the National Institute of Homoeopathy on April 7, 2025, with a clinical history of secondary infertility of two years' duration. Her presentation included associated symptoms of scanty menses, leucorrhea, and headaches. Mentally, she is sensitive to contradiction, fears being alone, and suffers from deep grief regarding her inability to conceive. Ultrasound (USG) showed polycystic ovarian morphology, and blood test indicated a prolactin level of 52.11 ng/ml. This indicates the diagnosis of PMOS with secondary infertility. Intervention and Outcome The remedy selected was NATRUM CARBONICUM. The patient was followed up for 12 months. After taking NATRUM CARBONICUM 0/1 to 0/12, her condition improved markedly; USG report showed that the polycystic morphology was resolved and the serum prolactin level came to normal, from 52.11 ng/ml to 19.72 ng/ml. She subsequently became pregnant, confirmed by a positive urine HCG test and a serum beta-HCG level of 95.2 mIU/ml. Modified Naranjo Criteria for Homoeopathy (MONARCH) score was reported as +8. Conclusion The case was followed for 12 months with a positive result of pregnancy after individualized homoeopathic treatment. Constitutional homoeopathy was reported to be successful in the treatment of PMOS with secondary infertility.

Homeopathic medicines from plant sources such as Nux vomica face skepticism due to presumed absence of original material in high potencies (30cH, 200cH) whose dilution exceeds Avogadro's number. Whilst nanoparticles exist in metal-derived preparations, physicochemical characterization of plant-based remedies remains limited.This study aimed to analyze Nux vomica potencies (Q to 200cH) to determine nanoparticle presence, stability and retained molecular signatures.We characterized Nux vomica potencies using dynamic light scattering (DLS) for particle size distribution, electrophoretic light scattering for zeta potential, UV-vis spectroscopy for electronic absorbance profiles, and Fourier transform infrared (FTIR) spectroscopy for functional group analysis. Measurements were compared with ethanol control.DLS revealed bimodal particle distribution in nanometer (140-697 nm) and micrometer (0.8-2.5 µm) ranges across potencies, indicating complex colloidal structures. Zeta potential confirmed stable, negatively charged suspensions, with a negative charge spike at 60cH (-16.85 mV), suggesting stable nanoaggregates. UV-vis spectroscopy showed peaks at 261 nm (strychnine) and 331 nm (brucine), with a broad band between 920 and 1,025 nm. A hypsochromic shift occurred with increasing potencies. Higher potencies showed shifts toward shorter wavelengths, changes in peak intensities, and altered absorption patterns, suggesting solvent-related structural modulation. FTIR spectra showed absorption bands for OH, C-H, N-H, C = O, C-N and C-O stretching vibrations, representing sample constituents.This study provides evidence that high-potency Nux vomica preparations contain stable nanostructures and retain molecular signatures of source material. The non-linear changes in particle size, surface charge and molecular architecture suggest that succussion induces dynamic cyclical transformations in the colloidal system.

Objectives: The primary objective of this study was to evaluate the comparative effectiveness of polarity analysis (PA) and classical repertorisation (CR) for managing knee OA. The secondary objectives were to evaluate the effectiveness of individualised homoeopathic medicine for treating OA and evaluate the utility of the CR method. Material and Methods: An open-label, randomised (1:1) trial was conducted at the National Institute of Homoeopathy, Kolkata, India. Patients were randomised to receive homoeopathic medicines repertorised with the PA ( n = 35) or CR ( n = 35) method using Boenninghausen’s therapeutic pocket book (BTPB). The Mann–Whitney test and Wilcoxon matched-pairs signed-rank test were used to compare the patients at baseline and after 6 months of treatment. Results: No statistically significant difference was seen between the two arms (PA and CR) after 6 months of treatment for the primary outcome. Within-group analysis done at baseline and after 6 months of treatment revealed that homoeopathic treatment and the CR method were effective. The frequently used medicines were Pulsatilla, Bryonia alba, Rhus tox, Sulphur, Calcarea carb, Arnica, Sepia, Phosphorus, Lycopodium, Natrum mur and Nux vomica . Conclusion: Prescriptions made using Heiner Frei’s PA do not produce any effect different from prescriptions made through the CR method using the BTPB in patients with knee OA. The homoeopathic treatment and prescription done through CR were found to be effective in managing knee OA. Further trials of similar design and enhanced methodological rigour are warranted.