Saint Petersburg State Institute of Technology (Technical University) (Russian: Санкт-Петербургский Технологический Институт (Технический Университет)) was founded in 1828. It is one of the oldest institutions of higher education in Russia, and it currently trains around 5,000 students.
The surface modification of aluminosilicate fibers by Al-doped ZnO particles provides the significant enhancement of photocatalytic and adsorptive properties. XRD, EDXA and SEM analysis, luminescent spectroscopy, the study of adsorptive and photocatalytic were used for the characterization of modified fiber composites. The obtained composites demonstrate the intensive photogeneration of chemically active singlet oxygen under the UV-A irradiation. The increase in the radiation power density provides a significant increase (+60 %) in the intensity of singlet oxygen photogeneration. It was found that the oxide coating accelerates significantly the processes of Aniline Blue adsorption in aqueous solutions on the surface of fibers and its photocatalytic decomposition under the action of near-UV (lambda = 395 nm) radiation. The dye adsorption process kinetics is well described by a pseudo-second-order kinetic equation. The application of oxide coating on the surface of fibers remarkably increases the effectiveness of dye photocatalytic decomposition in aqueous solutions. The rate of photocatalytic decomposition of dye molecules in the solution is described by a pseudo-second-order kinetic equation.
This study examines the influence of chemical composition and sintering temperature on the structural and thermal properties of preceramic and ceramic materials based on solid solutions in the (1-x)YPO4-xGdPO(4) (0.00 <= x <= 0.37) system with a xenotime structure. Precipitation at pH approximate to 1 leads to formation of xenotime-like nanoparticles along with an X-ray amorphous phase that partially crystallizes after heat treatment at 800 degrees C for 12 h. Subsequent pressing and sintering at 1200-1400 degrees C produced ceramics with total porosity of similar to 30%. Incorporation of Gd3+ into the YPO4 xenotime matrix was found to suppress grain and pore growth. The thermal diffusivity and conductivity of the ceramics in the 25-925 degrees C range are lower than those of YPO4 ceramics, consistent with their higher porosity (similar to 30%) and enhanced phonon scattering in the solid solutions. The Aivazov-Domashnev relation was applied to describe the dependence of thermal conductivity on porosity, composition, and temperature.
Transparent glass-ceramics (GCs) of lithium aluminosilicate, aluminogalliumsilicate, and galliumsilicate systems based on Fe2+-doped nanocrystals with spinel structure were developed by secondary heat-treatments of iron-doped glasses melted in reducing conditions. Their structure and spectral properties are studied. The first results of application of GCs based on Fe2+:γ-Ga2O3 nanocrystals for passive Q-switching of erbium glass laser at 1.53 μm are presented.
An injection-jet system for aeration of liquids has been developed and studied, which differs from traditional surface jet systems by the presence of downpipes that allow the gas phase (air, ozone-air mixture) to be supplied to a depth of 4-5 meters. The injection-jet ventilation system with downpipes is not inferior in performance to the best traditional systems and surpasses them in terms of ease of use. The system is recommended for use in wastewater treatment processes both in aerotanks with activated sludge and in bioreactors with immobilized microflora. It can also be used in installations for ozonation of water and flotation devices for wastewater treatment from petroleum products. As a result of conducting and processing the results of laboratory experiments, equations were obtained that allow calculating the surface and volume coefficients of oxygen mass transfer from air to liquid in the active and bubbling zones of aerated facilities. The obtained dependences can later be used to calculate the oxidizing capacity of injection-jet wastewater aeration systems in wastewater treatment plants
This study reports the design, synthesis, and biological evaluation of two novel phthalazinone-based carboxamides, N -(3-(3-methylbutanamido)phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide and N -(4-(3-methylbutanamido)phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide, as potential poly(ADP-ribose) polymerase-1 (PARP1) inhibitors. Structure-based molecular docking indicated favorable binding of both compounds within the PARP1 active site, with binding energies of − 8.5 and − 7.5 kcal·mol⁻¹, respectively. The stability and key interaction patterns of the more potent meta-substituted analogue were further validated by 250 ns molecular dynamics simulations. In silico ADMET profiling suggested acceptable drug-like properties for the synthesized compounds. Biochemical evaluation revealed enhanced inhibitory activity of the meta-substituted derivative against recombinant PARP1. Furthermore, both compounds exhibited cytotoxic effects in BRCA-mutant breast cancer cell lines, Capan-1 (BRCA2 c.5946delT) and MDA-MB-436 (BRCA1 c.5396 + 1G > A). Comparative analysis highlights the critical influence of the substituent position on the phenyl ring in modulating PARP1 binding stability and inhibitory activity. These findings identify the phthalazinone carboxamide scaffold as a promising platform for further structural optimization toward potent PARP1 inhibitors.
