Technopolis Oyj is a Finnish privately held company providing business incubator office space and services. Technopolis owns and operates 16 campuses located in the Nordic and Baltic region, often near universities or city centers. 45,000 people work and 1,500 companies operate in the business incubators. Originally from Oulu, Technopolis incubators are located also in Espoo, Helsinki, Vantaa, and Tampere in Finland, and in Oslo, Norway, Vilnius, Lithuania, Tallinn, Estonia, Luxembourg as well as in Gothenburg and Stockholm, Sweden. Thus, it has spread into most university cities in Finland. Most of the client companies are in the field of technology or services, although the company strategy is to expand to healthcare and education.In August 2018 Kildare Nordic Acquisitions S.à.r.l. announced a public cash tender offer on all shares in Technopolis Plc. On 31 December 2018 Kildare held 97.4% of all shares..
This study presents both experimental tests and numerical analyses to predict the dynamic structural behavior of birch plywood sheets under impact conditions. The comparison between the ballistic curves and ballistic limits obtained numerically and experimentally highlights the accuracy of the model in simulating the material response. Birch plywood, with its multilayer cross-laminated structure, demonstrates excellent impact resistance, effectively distributing and dissipating the applied forces. This configuration significantly reduces crack propagation and enhances energy absorption, making it a robust material for dynamic loading conditions. The paper introduces a detailed model for the ply fabric material of birch plywood, along with a comprehensive set of material parameters, providing a solid foundation for further research and application. The numerical analysis of the average impact force across the range of impact velocities considered offers valuable insights into the material performance. These findings further validate the suitability of birch plywood for structural applications requiring impact resistance. This work contributes to a deeper understanding of the material dynamic behavior and advances the knowledge of engineered wood products in impact-related contexts, paving the way for more informed decisions in material selection for demanding structural applications.
Studies on epigenetic modifications that could enable the tissue-specific partitioning of a general pool of circulating cell-free DNA for diagnosing myocarditis were analyzed. Despite the long history of research on cardiovascular disease, the actual incidence of myocarditis within the population remains unclear, as the condition is difficult to detect using conventional diagnostic methods. The advantages of screening a pool of cell-free DNA in the peripheral blood for detecting various pathologies (such as cancer, fetal aneuploidies, and transplant rejection) have been acknowledged worldwide. However, this approach is limited when analyzing the cell-free DNA derived from the reference genome. DNA methylation is one of the most crucial and well-studied mechanisms of epigenetic regulation. The aberrant methylation status of candidate genes is implicated in the development of cardiovascular diseases and may serve as a marker for assessing their progression. The methylation patterns are unique to each cell type, remain consistent among the same cell type within an individual, and are characterized by high stability. The studies reviewed identified loci associated with cardiomyocyte-specific patterns of DNA methylation. Moreover, in various diseases of the circulatory system, the same cytosine–guanine dinucleotide sites were found to be differentially methylated. This finding not only confirms the close association between DNA methylation profiles and cardiovascular diseases but also supports the hypothesis that the methylation status of specific cytosine–guanine dinucleotide sites has high diagnostic specificity for various pathologies. Thus, an analysis of cell-free DNA methylation profiles confirms its tissue-specific origin and enables the development of highly specific diagnostic approaches for myocardial disorders. Furthermore, comparing the methylation levels of identical cytosine–guanine dinucleotide sites offers promising opportunities for the development of highly specific diagnostic systems for myocarditis and other cardiovascular diseases.
BACKGROUND: Extreme conditions and the specific demands of military profession cause stress in military personnel who exhibit signs of neuropsychological instability, which disrupts their functional state and can lead to erroneous actions, emergency situations and, consequently, failure in training and combat missions. Existing methods for assessing an individual’s neuropsychological stability have certain limitations, so the development and introduction of additional, objective techniques for diagnosing neuropsychological stability and signs of instability in military personnel are highly relevant. AIM: To develop a mathematical model for diagnosing signs of neuropsychological instability in military personnel using stabilometry. MATERIALS AND METHODS: The study involved 50 servicemen with similar military occupational specialty, whose average age was 24.05±1.02 years. Assessment of their professional skills and personal traits was carried out using the General Fitness for Military Service-3 method. Based on the data obtained, the sample was split into two groups: No signs of neuropsychological instability (n=36; 72%) and Signs of neuropsychological instability (n=14; 28%). The short-term locomotion memory was analyzed using the Triangle test on the Stabilan-01-2 stabilizer. The significance of differences between the groups was assessed using the Mann–Whitney U test. The multiple regression method and discriminant analysis were used to develop decision rules. RESULTS: Servicemen with signs of neuropsychological instability exhibited lower balance function stability at all stages of testing. Locomotion memory — along with image, emotional, and verbal-logical memory, which characterizes mental activity — can serve as a marker for identifying signs of neuropsychological instability. We developed a diagnostic model for assessing signs of neuropsychological instability in servicemen, which has high sensitivity and specificity. We also proposed the decision rules to classify military personnel into either exhibiting or not exhibiting signs of neuropsychological instability based on the results of short-term locomotion memory testing using stabilometry. CONCLUSIONS: The use of stabilometry as an additional method for objectifying aptitude screening results will enhance the effectiveness of selection processes in the Armed Forces of the Russian Federation.
Introduction. Issues related to the epidemiologic aspects and clinical manifestations of poisoning by neurotoxicants, whose effects cause serious harm to the health of victims, are highly relevant. Acute and chronic poisoning can be manifested through diverse patterns; however, regardless of the type of neurotoxicant, all victims experience asthenovegetative and psychoorganic syndromes. These syndromes can develop during both toxicogenic and somatogenic phases of poisoning, manifesting in the period of its long-term consequences. Objective. Scientific substantiation of the risks of poisoning by neurotoxicants, which pose a serious threat to public health due to their systemic toxic effects and the development of multiorgan pathology, including at the stage of long-term consequences of poisoning. Discussion. In Russia, among various types of acute poisoning, intoxications by substances causing primary damage to the central nervous system rank first. The routes of entry of neurotoxicants into the body are indicated, and the forms of manifestation of neurotoxic processes are described. The pathogenesis of the toxic action of organic solvents, heavy metal salts, barbiturates, and carbamates is analyzed. Toxic neurotropic substances can adversely affect the nervous system both directly and indirectly, through damage to other organs and systems. Clinical cases of acute poisoning by neurotoxicants are described. After poisoning by representatives of the group of neurotropic toxicants, after a certain period of time, the victim develops long-term consequences with a highly varying clinical picture. Conclusions. The presented data on poisoning exposures to neurotoxicants demonstrate the clinical and pathogenetic significance of their effects not only on the central nervous system but also on other organs and tissues, the development of systemic pathological processes and multiorgan pathologies. The identified features of the toxic action must be taken into account when analyzing the health risks to victims of poisoning with neurotropic toxicants. The most significant manifestations of the effects on other organs/tissues should be reflected in the protocols for diagnosing the severity of such poisoning accidents and their long-term consequences, as well as in the use of metabolic and cytoprotective agents for their treatment.
Purpose of research . Professional activity of servicemen is directly related to high levels of mental and physical stress. Negative consequences of stress in servicemen are not only health problems, but also the risk of task failure. Therefore, the development of tools for assessing stress tolerance in military personnel, including in field conditions, becomes an urgent task. Existing complexes for assessing stress tolerance in servicemen, as a rule, have the following disad- vantages: large size, insufficient mobility, mandatory connection to a computer, installation of specialised software, relatively high cost, subjective nature of assessment, lack of differentiated assessment for fear and anxiety, having different morphofunctional basis. Therefore, the aim of the study is to develop a prototype of a portable system for differentiated assessment of the level of stress tolerance of military personnel. Methods . The stress tolerance assessment model is ‘predictable-unpredictable threat’. The development of the elec- tronic board was carried out using modern computer-aided design systems: NI Multisim v 14.3, Micro-Cap v 12.2.0.5, KiCad v 8.0.6, Compass-Graphic v 23, Mathcad v 15. The software component of the system is implemented using Python v 3.10 and libraries: PySide6 v 6.7.2, docx v 0.2.4, Docxcompose v 1.4.0, Cryptography v 43.0.0, SQLite v 3.47.0, Pyinstaller v 6.11.0. The housing of the portable system was modelled in Solidworks 2018 software. IDEA Maker software was used to convert the 3D model into 3D printer control commands. Results . A conceptual model of a portable system for assessing stress tolerance of military personnel based on the predictable-unpredictable threat assessment model is presented. A prototype of this system was implemented based on the conceptual model. Conclusion . The introduction of a portable system for differentiated assessment of stress tolerance into the daily prac- tice of medical and psychological service of the Armed Forces of the Russian Federation will contribute to the timely adoption of measures to preserve and improve the health of personnel, as well as to improve the efficiency of military- professional activity, and to preserve the professional health of servicemen.
