United Medical and Dental College (UMDC) (Urdu: یونائیٹڈ میڈیکل اینڈ ڈینٹل کالج) is a medical college located in Karachi, Pakistan. The college gives admission to 100 Bachelor of Medicine, Bachelor of Surgery & Medicine students each year. It has three affiliated hospitals located at different location in the city. UMDC is enrolling its ninth Batch of students in 2020. UMDC has been ranked amongst the top ten medical colleges in Pakistan and in the top two in Sindh by the Pakistan Medical Commission (PMC).The college is affiliated with Jinnah Sindh Medical University and is recognized by the Pakistan Medical and Dental Council and Ministry of Health, Pakistan Ministry of Health. The college is listed in the International Medical Education Directory (IMED) and World Directory of Medical Schools (WDOMS).
Edaravone dexborneol (ED), a combination of edaravone and ( +)-borneol, offers antioxidant and anti-inflammatory neuroprotection in acute ischemic stroke (AIS). Prior meta-analyses were limited by small sample sizes, inclusion of observational studies, and lack of subgroup evaluations. To assess the efficacy and safety of ED in AIS, including patients undergoing endovascular thrombectomy (EVT). We systematically reviewed randomized controlled trials (RCTs) up to February 2026 using PubMed, Embase, Scopus, Cochrane Library, and ClinicalTrials.gov. The primary outcome was excellent functional recovery (mRS 0–1 at 90 days). Secondary outcomes included mRS 0–2 and 3–6, NIHSS changes, mortality, hemorrhagic complications, cognitive and functional measures, and adverse events. Risk of bias and certainty of evidence were evaluated using RoB 2 and GRADE. Eight RCTs (n = 4,197) were included. ED significantly improved mRS 0–1 (RR = 1.14; 95
It is well known that inguinal hernia repair in geriatric patients carries a higher risk of postoperative complications compared to younger patients. One of the key factors influencing these complications is the surgical technique employed. However, there is limited knowledge regarding the impact of laparoscopy on elderly patients. This prospective randomized study aims to compare the outcomes of laparoscopic and open hernia repair techniques in this patient population. Between April 2023 and April 2024, 120 consecutive patients aged 65 years and older with inguinal hernia were randomly assigned to one of two groups: the laparoscopic TEP group (n = 60) and the open (Lichtenstein) procedure group (n = 60). The study was registered at ClinicalTrials.gov (NCT06417346). The primary outcome of this study was the comparison of postoperative complication rates. Secondary outcomes included comparisons of hernia types, operative times, postoperative pain levels, and recurrence rates. A total of 120 patients were followed up for 12 months. The mean age was 71.7 ± 6.5 years in the open group and 69.6 ± 3.9 years in the TEP group (p = 0.18). The mean operative time was 35.8 ± 7.8 min in the open group and 36.3 ± 8.7 min in the TEP group (p = 0.92). The mean time to return to normal daily activities was 10.6 ± 4.3 days in the open group and 7.5 ± 2.4 days in the TEP group (p < 0.001). On postoperative day 1, the VAS score was 3.7 ± 1.3 in the open group and 2.9 ± 1.1 in the TEP group (p < 0.001). At the end of the first month, the VAS score was 2.6 ± 1.0 in the open group and 1.7 ± 0.9 in the TEP group (p < 0.001). Chronic pain was observed in 6 patients (10
Resistant hypertension remains a major clinical challenge despite multidrug therapy. Baxdrostat, a highly selective aldosterone synthase inhibitor, has emerged as a novel treatment option. We conducted an updated systematic review and meta-analysis to evaluate its efficacy and safety. PubMed, Embase, Scopus, Cochrane Library, and ClinicalTrials.gov were searched through April 30, 2026, for randomized controlled trials comparing baxdrostat with control in uncontrolled or resistant hypertension. Random-effects meta-analyses, Trial Sequential Analysis (TSA), subgroup/sensitivity analyses, risk of bias, and GRADE evaluations were performed. Baxdrostat significantly reduced seated systolic blood pressure (SBP) overall (MD: − 6.69 mmHg, 95
