库奥皮奥大学

We investigated the associations of pro- and anti-inflammatory fatty acids (FAs) with cartilage degradation, functional limitations, pain, and psychological well-being in knee osteoarthritis (KOA). Fasting plasma samples were obtained from controls (n = 12) and from end-stage KOA patients at baseline (n = 13), and 3 months (n = 11) and 12 months (n = 9) after knee replacement surgery. FA composition in total lipids was analyzed with gas chromatography and mass spectrometry. Cartilage loss was determined by magnetic resonance imaging, and knee pain and disability by physical performance and quantitative sensory testing, neuromuscular examination, and several questionnaires. The associations between variables were tested with the univariate analysis of variance adjusted for age and body mass index. KOA was characterized with elevated baseline 16:1n-7 percentages, while the proportions of 24:0 decreased 12 months after surgery and those of 24:1n-9 decreased 3 and 12 months after surgery. Several FA variables, such as 20:3n-6, 20:4n-6, long-chain saturated FAs, and 24:1n-9, were associated with pain, stiffness, disability, pain self-efficacy, or mental health. Circulating FAs can predict KOA symptoms, independent of age and body adiposity, and provide promising targets to design novel pain treatments.

This is the first nationwide population-based study to assess educational and regional differences in the incidence and survival of primary central nervous system lymphoma (PCNSL) in Finland. Data were extracted from the Finnish Cancer Registry based on the histological diagnosis and tumor location for cases of large B-cell lymphoma (LBCL) between 2007 and 2022. Data were divided into five healthcare regions of the Finnish healthcare system, which included 623 PCNSL patients (48

Study Design.Retrospective registry study.Objective.To investigate the influence of depressive symptoms on return to work (RTW) after lumbar spine fusion (LSF) surgery over a two-year follow-up. A secondary objective was to evaluate the development of depressive symptoms separately in patients who succeeded or failed to RTW after surgery.Background.Depressive symptoms are overrepresented in patients undergoing LSF surgery. The effect of depressive symptoms on RTW after LSF surgery has not yet been widely studied.Materials and Methods.A total of 348 consecutive patients available to the workforce underwent LSF surgery. Depressive symptoms were evaluated at baseline and three, 12, and 24 months postoperatively using the MHI-5. Lower scores have been shown to indicate greater depressive symptoms, and a cutoff score of <= 68 indicates current major depressive disorder (MDD). Cumulative RTW and MHI-5 scores were prospectively followed up at the aforementioned time points.Results.Before surgery, almost half (46%) of the patients had MDD. The presence of preoperative MDD indicated a lower RTW at two years [72% vs. 82%, adjusted HR: 0.77 (95% CI: 0.61 to 0.98)]. The probability of RTW was correlated with an increase in the MHI-5 score until the inflection point of 70, after which a further increase in the MHI-5 score no longer increased the probability of RTW. In addition, the MHI-5 score was significantly higher than baseline at three months postoperatively [13 points (95% CI: 10 to 15)] and remained higher in patients who RTW during two years. However, only a marginal increase in MHI-5 was observed in those who failed to RTW. This finding indicates fewer depressive symptoms in patients who successfully RTW.Conclusion.Patients with preoperative MDD were less likely to RTW after LSF surgery. After surgery, depressive symptoms diminished in the group who did successfully RTW.Level of Evidence.Level III.

Complete characterization of the genetic effects on gene expression is needed to elucidate tissue biology and the etiology of complex traits. Here, we analyzed 2,344 subcutaneous adipose tissue samples and identified 34K conditionally distinct expression quantitative trait locus (eQTL) signals in 18K genes. Over half of eQTL genes exhibited at least two eQTL signals. Compared to primary signals, non-primary signals had lower effect sizes, lower minor allele frequencies, and less promoter enrichment; they corresponded to genes with higher heritability and higher tolerance for loss of function. Colocalization of eQTL with conditionally distinct genome-wide association study signals for 28 cardiometabolic traits identified 3,605 eQTL signals for 1,861 genes. Inclusion of non-primary eQTL signals increased colocalized signals by 46%. Among 30 genes with ≥2 pairs of colocalized signals, 21 showed a mediating gene dosage effect on the trait. Thus, expanded eQTL identification reveals more mechanisms underlying complex traits and improves understanding of the complexity of gene expression regulation.

The relationship between rheumatoid arthritis (RA) and fracture risk was estimated in an international meta-analysis of individual-level data from 29 prospective cohorts. RA was associated with an increased fracture risk in men and women, and these data will be used to update FRAX®. RA is a well-documented risk factor for subsequent fracture that is incorporated into the FRAX algorithm. The aim of this study was to evaluate, in an international meta-analysis, the association between rheumatoid arthritis and subsequent fracture risk and its relation to sex, age, duration of follow-up, and bone mineral density (BMD) with a view to updating FRAX. The resource comprised 1,909,896 men and women, aged 20–116 years, from 29 prospective cohorts in which the prevalence of RA was 3