Fungi have emerged as versatile biotechnological platforms for addressing environmental challenges with potential co-benefits for human health. Among them, Pleurotus ostreatus stands out for its ligninolytic enzyme systems (notably laccases), capacity to valorize lignocellulosic residues, and ability to form functional mycelial materials. We conducted an evidence-mapped review, based on a bibliometric analysis of the Scopus corpus (2001–2025; 2085 records), to characterize research fronts and practical opportunities in environmental remediation and sustainable bioprocesses involving P. ostreatus. The mapped literature shows sustained growth and global engagement, with prominent themes in: (a) oxidative transformation of phenolic compounds, dyes and polycyclic aromatic hydrocarbons; (b) biodegradation/bioconversion of agro-industrial residues into value-added products; and (c) development of bio-based materials and processes aligned with the circular bioeconomy. We synthesize how these strands translate to real-world contexts, reducing contaminant loads, closing nutrient loops, and enabling low-cost processes that may indirectly reduce exposure-related risks. Key translational gaps persist: standardization of environmental endpoints, scale-up from laboratory to field, performance in complex matrices, life-cycle impacts and cost, ecotoxicological safety, and long-term monitoring. A practical agenda was proposed that prioritizes field-scale demonstrations with harmonized protocols, integration of life-cycle assessment and cost metrics, data sharing, and One Health frameworks linking environmental gains with plausible health co-benefits. In conclusion, P. ostreatus is a tractable platform organism for sustainable remediation and bio-manufacturing. This evidence map clarifies where the field is mature and where focused effort can accelerate the impact of future research.
Agricultural performance is often interpreted through agronomic inputs and technological progress; however, the translation of knowledge into production depends on the structural environments in which food systems operate. This study examined the association between food-security-related publication activity and crop production across global income settings from 2000 to 2025, while testing whether governance, health-system, and financial indicators modify that association. A longitudinal ecological panel was constructed, integrating 61,158 Scopus-indexed peer-reviewed articles on food security and related dimensions of healthy food access and availability with 23 crop production indicators grouped into staple, horticultural, and commodity domains. Income-stratified regression models were followed by hierarchical mixed-effects models and moderator screening. In exploratory stratified models, 67 of 92 income-specific associations reached nominal significance; however, only 5 of those 67 associations (7.5%) remained statistically significant after multilevel modelling and false discovery rate correction. Robust associations were concentrated in selected staple and horticultural outcomes, whereas most commodity indicators lost significance after hierarchical adjustment. Structural moderators related to territorial control, corruption, healthy life expectancy, health researcher density, healthcare access and quality, and official development assistance shifted the conditional slopes linking publication activity to crop output. These findings do not support a uniform linear relationship between publication growth and production volume. Instead, they suggest that the alignment between research ecosystems and agricultural output is structurally conditioned and likely mediated by institutional capacity, health-system resilience, and implementation environments. The ecological design, the use of publication counts as an indirect proxy, and the reliance on production volume rather than yield or efficiency should be considered when interpreting these results.
Intestinal failure (IF) is a rare but serious condition associated with high morbidity, mortality, and healthcare resource use. Although consensus-based definitions for IF exist, their adoption in randomized controlled trials (RCTs) remains uncertain. This variability compromises the comparability of evidence and hinders the development of robust clinical guidelines. The aim of this study was to examine the conceptual and operational consistency of IF definitions in RCTs, assess methodological and reporting quality, and explore implications for research synthesis and clinical decision-making. Systematic review of RCTs. We searched PubMed/MEDLINE, Embase, Web of Science, and Scopus up to May 2025 for RCTs involving participants with IF. Two reviewers independently extracted data, focusing on the presence and nature of IF conceptual and operational definitions, and assessed methodological and reporting quality. Studies were categorized by quality thresholds defined a priori. From 9354 records screened, 12 RCTs (2011–2025) involving 617 participants with IF were included. Most were conducted in high-income countries and focused on adults, although some involved pediatric short bowel syndrome (SBS) and intestinal failure-associated liver disease populations. Only 3 trials (25
Climate change research has expanded at an unprecedented speed, yet its growth has not necessarily translated into proportional advances in global resilience, equity, and climate justice. This Perspective introduces the conceptual framework of scientific coherence, defined as the alignment between the volume, geographic origin, thematic focus, and translational capacity of climate research and the real distribution of climate vulnerability and risk. Using a scoping scientometrics snapshot of Scopus-indexed, final-stage journal publications on climate change (n = 483,333; 1946–2024), we describe structural imbalances favoring high-income regions while low- and lower-middle-income countries, despite being the most affected, remain significantly underrepresented. Under a conservative, title-based filter, only 0.001% of these Scopus-indexed climate-change journal documents were identified as integrating a meta-research perspective, indicating a very small lower-bound share. We argue that climate science requires a systematic evaluation of its evidence-generation system to better assess whether research agendas, funding priorities, and implementation strategies reflect global needs rather than geographic scientific privilege. We propose a four-pillar framework of scientific coherence, geographic, thematic, temporal, and translational, as a pathway to strengthen climate research utility, accelerate policy impact, and embed climate justice into scientific production. This perspective positions meta-research as a useful roadmap for future implementation in high-value, globally relevant climate science, aligning directly with the cross-disciplinary and impact-driven mission of the global scientific progress.
Background: Screening instruments are brief and simple tools designed to identify alterations in cognitive functioning, as well as to rule out or confirm the presence of cognitive dysfunction. Systemic lupus erythematosus (SLE) is an inflammatory disease that affects multiple organs of the human body, including the nervous system, which can cause neuropsychiatric symptoms such as cognitive dysfunction. Objective: To analyze the scientific evidence on cognitive screening tests used in SLE and the cutoff points suggested in academic literature. Methodology: A systematic review was conducted from 2014 to the second half of 2024, in databases such as PubMed, Scopus, Web of Science, ScienceDirect, Redalyc and SciELO, based on combinations of keywords and Boolean operators: "cognitive dysfunction", "cognitive impairment", "cognitive decline", "lupus", "systemic lupus erythematosus", "SLE", "Montreal Cognitive Assessment", "MoCA", “MMSE”, “Mini-Mental State Examination”, “INECO Frontal Screening", "INECO", "Addenbrooke's Cognitive Examination", and "ACE-R III". Results: The search yielded a total of 564 works, of which 31 documents met the inclusion criteria and were analyzed. The results show that the MoCA is the preferred tool by physicians and specialists worldwide for cognitive screening in patients with SLE, both in patients with and without clear neuropsychiatric symptoms. Conclusion: The literature consistently supports a cutoff score of <26 on the MoCA as the most widely used threshold for identifying cognitive dysfunction in individuals with systemic lupus erythematosus, with this criterion receiving the strongest empirical validation across published studies. However, some studies have explored lower cutoff scores to improve the instrument's specificity and sensitivity, especially in the SLE population.
