BACKGROUND:Efanesoctocog alfa (EFA) is an ultra-long half-life FVIII product. However, measuring the level of EFA using standard one stage (OSA) and Chromogenic assays (CA) is affected by both underestimation and overestimation when using some commonly used APTT reagents for OSA and overestimation when using CA assays. OBJECTIVES:ECAT and NEQAS BC distributed samples containing EFA to centres for measurement of EFA using assays available locally. The aim was to provide method specific data and recommendations for additional OSA or CA assays. METHODS:In Autumn 2024, four samples with levels of EFA between 5 and 100 IU/dL (based on potency label) were buffered and lyophilized for distribution to 300 hospital and university laboratories. RESULTS:Two-hundred participants returned 174 OSA and 148 CA results for samples EFA 24:01-24:04. Twelve different APTT reagents, six were used by (n ≥ 10) and 10 different chromogenic assays were employed, of which four were used by (n ≥ 10). CONCLUSION:The NEQAS BC and ECAT exercise confirmed the field study: over-estimation for Actin FS OSA and all CA assays at all EFA levels plus an under-estimation for SynthasIL OSA at EFA levels of: 20, 50 and 100 IU/dL. Centres using Actin FSL on a Siemens/Sysmex or Stago analyser plus centres using Synthafax on a Werfen analysers had median recoveries within ±25% compared to the assigned potency for samples at EFA levels of: 20; 50 and 100 IU/dL. Centres using CK Prest and Pathromtin had median recoveries within ±25% compared to the assigned potency for samples at an EFA levels of 100 IU/dL.
Here, we report a partial genome sequence of varicella-zoster virus, recovered through metagenomic sequencing from a skin lesion sample collected from a 31-year-old male from Mombasa, Kenya, in August 2024. Phylogenetic analysis placed this isolate in varicella-zoster virus clade 5.
This chapter presents the analysis of an interview with the Latin American cultural anthropologist, Dr Hebe Vessuri. An account of Vessuri’s biography is offered, with insights into her experiences and her analyses of the roles she embodied as woman, mother, wife, migrant and scientist during times of political, social and economic disturbances in the countries she lived in the second half of 20th century. A particular focus was on the impact of living and working as an academic in Argentina, Venezuela, Brazil and Mexico. La Dra. Hebe Vessuri es una de las figuras más importantes en la antropología cultural latinoamericana. Con más de cuatro décadas de trayectoria como investigadora, ella ha contribuido a la consolidación y desarrollo de varias instituciones de educación superior y diversas redes de investigación, formando a muchas generaciones de académicos e investigadores. Sin embargo, su destacada carrera como investigadora social no puede ser vista sólo como una historia de éxito, sino también como una historia de conflicto, sorteando diversos obstáculos impuestos por la estructura política y social de los países donde trabajó, incluyendo la guerra y la dictadura. Como académicos noveles originarios de México y Venezuela, decidimos entablar una conversación con la Dra. Vessuri en 2022 para conocer más sobre vasta experiencia intelectual. En nuestro estudio, analizamos las percepciones de la Dra. Vessuri sobre su propia historia. La estructura de este capítulo sigue un orden cronológico para ilustrar episodios específicos en la vida de la Dra. Vessuri. Se utilizó el enfoque fenomenológico interpretativo para hacer el recuento de las vivencias de la Dra. Vessuri y realizar la interpretación de las mismas bajo los conceptos de condición migrante, condición de mujer y profesión académica. Nos interesaron los hechos y elementos contextuales de su biografía, junto con la interpretación que hizo nuestra entrevistada sobre su propia experiencia. Encontramos como los elementos de ser mujer, ser migrante y ser científica en América Latina en la segunda mitad del siglo XX implicó una serie de retos que marcaron el desarrollo de la Dra. Vessuri como profesional, pero también ilustran su labor como agente del cambio en diferentes sociedades.
Abstract Since the 1970s, specialized hemophilia centers have been established to optimize the complex and costly treatment of patients with severe bleeding disorders. In 2019, the first GTH guidelines on the structural and process quality of hemophilia centers were published. On this basis, a procedure for the certification of hemophilia centers has been established under the technical leadership of the GTH. These GTH guidelines are essentially based on the European Guidelines for the Certification of Haemophilia Centers published in 2013, created by the European Haemophilia Network (EUHANET). In 2023, this European guideline was revised by the EAHAD Accreditation and Audit of Haemophilia Centers Working Group. On this background, the GTH guidelines have now been revised to take relevant updates to the European guidelines into account.
