A ejaculação retrógrada é uma disfunção ejaculatória caracterizada pelo desvio total ou parcial do sêmen para a bexiga, resultante da falha no mecanismo de fechamento do colo vesical durante a fase emissiva da ejaculação. Embora seja um processo fisiológico indolor, sua relevância clínica é acentuada pelo impacto direto na fertilidade masculina e pelo desconforto psicológico causado pela ausência de fluido ejaculado (orgasmo seco). As causas variam desde iatrogenias cirúrgicas e neuropatias diabéticas até o uso de medicações específicas, como os alfabloqueadores. Este estudo teve como objetivo realizar uma revisão sistemática da literatura brasileira sobre os mecanismos fisiopatológicos da falha do colo vesical e as estratégias terapêuticas disponíveis, incluindo o manejo farmacológico e técnicas de recuperação de espermatozoides para fins reprodutivos. A análise dos dados reforça que o diagnóstico preciso, por meio da análise de urina pós-ejaculatória, é fundamental para o sucesso do manejo clínico. Conclui-se que a abordagem deve ser individualizada, priorizando a correção da causa base e o aconselhamento para a preservação do potencial de fertilidade do paciente.
This study evaluated the behavioral and productive responses of European quails (Coturnix coturnix) to environmental enrichments designed to mitigate monotonous confinement conditions. A total of 192 quails (96 females and 96 males) were distributed in a completely randomized 2 × 2 × 4 factorial design, comprising two lineages (LF1 and LF2), two sexes, and four enrichment treatments (control, beads, red wool, and beads + red wool), with 12 replicates per treatment combination. Behavior was recorded by eight cameras and assessed at five-minute intervals using an ethogram comprising 11 predefined behaviors. Behavioral diversity was evaluated using the Shannon index. Females had higher body weight, weight gain, and tissue mass than males, while lineage 2 showed higher body weight and tissue values than lineage 1. Enrichment did not affect surface body temperature, feed intake, or performance. A significant treatment × sex interaction indicated sex-dependent behavioral responses, with differences in behavioral diversity among male treatment groups. Overall, low-cost environmental enrichment promoted behavioral variation without impairing productive performance, although physiological stress indicators are needed for a more definitive welfare assessment.
A insônia crônica é um transtorno frequente associado a prejuízos no sono, no funcionamento diurno e na qualidade de vida. Embora a terapia cognitivo-comportamental para insônia permaneça como tratamento de primeira linha, a farmacoterapia constitui alternativa relevante quando essa abordagem é insuficiente, indisponível ou inadequada ao contexto clínico. O objetivo deste estudo foi analisar as evidências atuais sobre os avanços no tratamento farmacológico da insônia crônica, com ênfase na eficácia, segurança e individualização terapêutica. Trata-se de revisão integrativa da literatura, realizada nas bases PubMed/MEDLINE, Scopus, SciELO e ScienceDirect, incluindo publicações em português ou inglês entre 2016 e 2026. A matriz de síntese foi composta por 18 publicações. Os estudos demonstraram eficácia de diferentes classes farmacológicas sobre o início e a manutenção do sono, porém com diferenças importantes quanto à segurança e tolerabilidade. Benzodiazepínicos e Z-drugs mostraram eficácia, mas requerem cautela, especialmente em idosos. Os antagonistas dos receptores de orexina ampliaram as opções terapêuticas, com resultados favoráveis e dados crescentes sobre uso prolongado. Conclui-se que a escolha farmacológica deve considerar o padrão da insônia, idade, comorbidades, riscos, resposta prévia e duração prevista do tratamento.
Contemporary medical education faces the challenge of integrating technical and humanistic competencies, overcoming the predominance of the traditional biomedical model. Among the practices that facilitate this integration, theater has proven to be a privileged space for developing sensitivity, ethical reflection, and relational skills. This qualitative study analyzed the experiences of 33 medical students and alumni participating in a university theater group, seeking to understand how this experience influences their personal, social, and professional trajectories. Semi-structured interviews conducted between January and February 2025 were examined through thematic content analysis, ensuring rigor by theoretical saturation and triangulation. Four interrelated formative areas emerged: personal transformations, relational competencies, professional impacts, and belonging. Theater proved to be an aesthetic-affective formative methodology, reinforcing the pertinence of artistic practices in medical education as strategies for comprehensive training and the humanization of care.
Coffee farming is crucial for Brazil, the world leader in coffee production and export. Strategies like the "safra zero”, which involve practices such as skeleton pruning, have been adopted to rejuvenate coffee plants and optimize production in alternate years. This contributes to reducing costs and labor demand. Faced with the environmental and economic challenges of coffee cultivation, bio-inputs stand out as a sustainable alternative in crop management, especially during vegetative recovery phases. Therefore, this study aimed to evaluate the effects of applying bio-inputs to coffee plants subjected to skeleton pruning. The experiment was conducted using a randomized block design, in split plots, with eight treatments: five bacterial strains (UNIFENAS 100-94, Azospirillum brasilense, Pseudomonas fluorescens, Bacillus megaterium, and Bacillus subtilis), organized into six combinations, plus a treatment with A. brasilense isolated and a control, with four replicates. Applications occurred in March, April, August, and September. Plant height, plagiotropic branch length, and the number of buds were evaluated every 30 days. At the end, soil and leaf chemical analyses were also performed. Plant height and branch length did not differ significantly between treatments, but the number of buds showed a difference at 210 days when the UNIFENAS 100-94 and P. fluorescens strains were used. All analyzed variables evolved over time. Nutrient levels increased with the use of bio-inputs. It is concluded that these inputs show potential in the post-pruning management of coffee plants.
