Veer Narmad South Gujarat University is a public university located in the city of Surat, Gujarat, India. Previously known as South Gujarat University, it was renamed as Veer Narmad South Gujarat University(VNSGU) in 2004 in honour of the famous scholar and Gujarati poet Narmad. Established in 1965, the university offers undergraduate and postgraduate courses, including non-traditional postgraduate departments such as public administration, rural studies, comparative literature, and aquatic biology.
Plant growth-promoting rhizobacteria (PGPR) enhance rice productivity by boosting nutrient uptake and hormone production and pathogen suppression. However, identifying efficient and multifunctional PGPR strains adapted to specific rice-growing environments remains challenging. This study aimed to isolate and assess efficient rice rhizosphere PGPR from the rice rhizosphere for their growth-promoting potential under controlled conditions. Eighteen bacterial isolates were initially screened for key PGPR traits, including phosphate (P) and zinc (Zn) solubilization, indole acetic acid (IAA) production, potash (K) mobilization, and antagonistic activity. Based on superior performance, two isolates were identified as Acinetobacter junii SK13 (AJNAU-SK13) and Providencia vermicola SK16 (PVNAU-SK16). Their efficacy was evaluated under greenhouse conditions using individual (T1: AJNAU-SK13, T2: PVNAU-SK16) and combined (T3: AJNAU-SK13 + PVNAU-SK16) inoculations. All treatments significantly improved root and shoot growth, biomass, chlorophyll content, enzyme activities (protease, and amylase), and total soluble sugars (TSS) at 10 and 20 days after treatment (DAT). Notably, T2 increased root growth (150
Pyrimidines and their hybrid structures have remained an emerging research domain for organic chemists owing to their diversity in both synthetic and natural molecules and their distinct applications. Hence, developing strategies to improve the synthetic efficiencies of N-heterocycles and their timely assessment on biological targets is crucial. The incorporation of indole moieties into barbiturate structure represents a significant advancement in medicinal chemistry, offering enhanced therapeutic characteristics. Herein, we report a conventional and microwave-assisted, three-component domino reaction involving indole-3-carbaldehyde, heterocyclic primary amines, and barbituric acid or thiobarbituric acid in the presence of ceric ammonium nitrate to effectively synthesize a library of novel fused heterocyclic derivatives, which differ in terms of a pyridine, pyrimidine, pyrazine, thiazole, triazole, and tetrazole ring. FTIR, 1H NMR, 13C NMR, and HRMS techniques were employed to validate the structural integrity. The mechanistic route involves the establishment of new C–C and C–N bonds by Knoevenagel condensation, Michael addition, and intramolecular ring closure. All derived molecules were evaluated for antimicrobial activity and bioactivity score. The existing methodology has been shown to be more operational, environmentally benign, with reduce time from hours to minutes, no use of harmful solvents, and column chromatography, resulting in higher purity and excellent yields (75–92 Multicomponent synthesis of pyrimidine fused derivatives using Intramolecular heterocyclization with indole-3-carbaldehyde, barbituric acid or thiobarbituric acid and various heterocyclic amines under microwave and reflux conditions
This study provides the first assessment of the biological activity (pIC50) of a group of isonicotinamides derivatives as inhibitors of Glycogen synthase kinase-3 beta (GSK3β) in Alzheimer's disease. The analysis has been carried out by developing appropriate quantum descriptors using density functional theory. The study focuses on investigating the interactions between inhibitors and the biomolecule Asparagine. This is done by analyzing the total energy (E), electronegativity ( χ ), and electron transfer ( Δ N ) with the amino acid of the host protein GSK3β. These descriptors are found to be highly promising and can explain 91
The effect of quadrupole deformation (beta(2)) on heavy ion fusion is a fact that is well recognized phenomenon. In addition to the influence of quadrupole deformation (beta(2)), the potential impact of hexadecapole deformation (beta(4)) on sub-barrier fusion has been a topic of frequent discussion. Recently, a theoretical analysis was performed to examine the impact of hexadecapole deformations (beta(4)), employing the simplified coupled channels code CCFUS, which incorporates static deformations. In this study, we analyze the effect of the beta(4) of the target nucleus on fusion cross sections within the framework of the 3S-CMD model. For this purpose, we have chosen the reactions O-16 + Sm-154 and O-16 + Yb-174. The present research has calculated the fusion cross sections using the SBPM model as well. The calculated fusion cross sections using 3S-CMD model and SBPM are compared with each other as well as experiment.
The advancements of IoT (Internet of Things) in the medical sector led to the development of Internet of Medical Things (IoMT) and its application. IoMT is seen to enhance healthcare management through many applications such as device-integration, data delivery, analytics, automation, etc. A wide range of studies from 2011 to 2024, endorse that the need of IoT in healthcare is only meant to grow in the future. Significant potential improvements in operational efficiency through real-time data access and automation should be implemented in the future, along with addressing critical concerns like data privacy, interoperability issues, high implementation costs, and the need for robust cybersecurity measures.
