The Uka Tarsadia University is a Private University located in Bardoli, Surat, Gujarat, India. It was established by Tushar Patel and B.U. Patel, founders of Tarsadia Investments.
Radiation-induced skin injury is a common, dose-limiting toxicity of cancer radiotherapy caused by excessive reactive oxygen species (ROS), inflammation, and impaired epidermal repair. Current topical treatments mainly offer symptomatic relief and do not effectively address intracellular oxidative stress. This study reports a hyaluronic acid–functionalized, hesperidin-loaded solid lipid nanoparticle (HSP-HA-SLN) system designed to enhance dermal delivery, skin retention, and intracellular antioxidant activity. HSP-HA-SLNs were prepared by solvent injection and optimized using a Central Composite Design to achieve sub-300 nm particle size and high entrapment efficiency, followed by hyaluronic acid surface functionalization. The optimized formulation was characterized by dynamic light scattering, electron microscopy, thermal, and crystallographic analyses. In vitro drug release, cytocompatibility, intracellular antioxidant activity, and ex vivo skin permeation and retention were evaluated. The nanoparticles exhibited sustained diffusion-controlled drug release, high cytocompatibility, and significantly improved intracellular ROS scavenging compared to free hesperidin. The observed intracellular ROS reduction supports the potential of this system in radiation-induced oxidative stress conditions. Ex vivo studies showed enhanced dermal deposition with minimal surface residue, indicating localized drug reservoir formation. Overall, the HSP-HA-SLN platform overcomes key solubility, permeability, and retention limitations of hesperidin and represents a promising topical nanotherapeutic approach for potential application in radiation-induced skin injury.
Herein, we report a dual-state emissive (DSE) luminophore, DCZHPI, bearing a phenanthroimidazole (PI) core with carbazole substitution. Two concomitant polymorphs (DCZHPI-B and DCZHPI-G) of DCZHPI emerge upon slow evaporation from the MeOH/DCM system, each displaying a butterfly-like molecular architecture. These two polymorphs exhibit distinct luminescence properties due to packing structure variations. DCZHPI exhibits emission from the keto tautomer following an ESIPT mechanism with a large Stokes shift (similar to 120 nm) and high photoluminescence quantum yield (Phi sol = 57% and Phi solid = 2.5-24%). The photophysical properties and ESIPT have been investigated meticulously using experimental and theoretical calculations. Utilizing the photoswitachable properties of DCZHPI, we have demonstrated its application in confidential encoding and anti-counterfeiting writing/printing. We believe that all these properties make DCZHPI a prominent organic luminescent material for promising applications in bioimaging, chemosensing, data encryption, and organic optoelectronic systems.
The present study employed a three-step synthetic strategy to develop a series of novel (Z)-N-(2,4-dimethylphenyl)-3-(3-(((5-phenyl-1,3,4-thiadiazol-2-yl) imino) methyl)-1H-indol-1-yl) propanamide derivatives. This approach utilized readily available and cost-effective reagents under mild reaction conditions, affording the target indole-based compounds in good yields. Structural elucidation of the synthesized molecules was confirmed by infrared spectroscopy, mass spectrometry, and both 1H and 13C NMR analyses. The antimicrobial activities of the synthesized derivatives were evaluated by determining their minimum inhibitory concentrations (MICs) against a panel of bacterial and fungal strains. The results revealed that methoxy- and nitro-substituted derivatives exhibited significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa, whereas chloro, hydroxy, and nitro functionalized compounds demonstrated notable antifungal activity against Aspergillus niger and Aspergillus clavatus. Furthermore, molecular docking studies were performed using AutoDock software to investigate the binding interactions of the synthesized compounds with Staphylococcus aureus dihydrofolate reductase (DHFR) in complex with trimethoprim. In addition, in silico ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analyses were carried out to assess the physicochemical properties, drug-likeness, and therapeutic potential of the developed compounds.
Carvedilol (CAR) is a non-selective beta-blocker used in treating hypertension and heart failure. Existing analytical methods for CAR quantification face challenges in sensitivity, environmental sustainability, and efficiency. This study aimed to develop an innovative, highly sensitive, and environmentally friendly analytical method for picoscale determination of CAR in pharmaceutical formulations and biological samples. The research utilized a microwave-assisted micro-level Mannich-type derivatization to generate a CAR-linked fluorescent biosensing probe on TLC plates. The method development integrated principles of white analytical chemistry and Quality by Design (QbD) to optimize performance and minimize environmental impact. The developed method demonstrated exceptional sensitivity with detection and quantification limits in the picogram range (LOD: 3.0 pg/band, LOQ: 10 pg/band), surpassing conventional techniques. It showed high accuracy and precision in both pharmaceutical formulations (99.69-100.55
Flexible piezoelectric thin-film devices are gaining prominence in modern electronics due to their potential in intelligent and self-powered applications. The performance of such devices strongly depends on the dielectric properties of the active layer materials. In this work, hexagonal alpha-beryllium oxide (BeO) crystals are synthesized via a low-temperature sol-gel polymerization process, with citric acid (CA) as a precursor at varying concentrations (1-4 wt%). Among these, BeO-B8 (2 wt% CA) exhibited the highest dielectric constant (11.4). Further, a flexible piezoelectric nanogenerator (PENG) is successfully fabricated by combining polyvinylidene fluoride (PVDF) with various BeO-X formulations (X = A8, B8, C8, and D8). The BeO-B8/PVDF film combination exhibits the highest dielectric constant (24.87), indicating its potential for superior performance. A flexible piezoelectric nanogenerator (PENG) optimized with 0.5 wt% BeO-B8 can generate 8 V and 2.5 mu A under periodic mechanical stimuli, yielding a power density of approximate to 7.5 mu W/cm2 at 20 M Omega load resistance. The proposed composite material properties are characterized through techniques including XRD, SEM, AFM, FTIR, dielectric, mechanical, and electrical analyses. The fabricated BeO-B8/PVDF PENG achieves potential results for self-powered applications, including artificial e-skin for spatial pressure sensing, jaw and finger movement tracking, and biomechanical and acoustic energy harvesting, underscoring its versatility in next-generation electronics.
