Yashoda Hospitals is a chain of hospitals based in Hyderabad, Telangana, India. It has branches in Somajiguda, Secunderabad, and Malakpet, with another branch coming up in Hitec City. All of its branches are NABH and NABL accredited.It was recognised as a leading hospital for oncology in 2015 after becoming the first hospital to achieve the milestone of treating 10,000 patients using RapidArc technology.
Ventral hernia repair (VHR) is a common general surgical procedure. While robotic VHR (RVHR) has shown advantages in large, complex hernias, comparative evidence with laparoscopic VHR (LVHR) for smaller defects is limited. We conducted a prospective, real-world evidence study across 12 centers in India. Adults aged 18–65 years undergoing primary or incisional VHR with a defect ≤ 5 cm requiring mesh placement were included. Primary outcomes were postoperative pain and analgesic use within 14 days; secondary outcomes included quality of life (QoL), hospital stay, and perioperative complications. A total of 200 patients (101 RVHR, 99 LVHR) were analyzed, with comparable baseline characteristics. Defect size was larger in the RVHR group (p < 0.001). Median operative time was longer in RVHR (p < 0.001), while post-anesthesia care unit stay was shorter (p = 0.0026). RVHR was associated with faster recovery, including earlier return to daily activities (median 5 vs. 7 days, p < 0.001), fewer analgesic doses (2.55 ± 0.97 vs. 3.25 ± 1.55, p < 0.001), and shorter work restrictions (14 vs. 30 days, p = 0.0042). Pain outcomes favored RVHR, with consistently lower Numeric Rating Scale (NRS) scores, greater improvement in PROMIS pain intensity scores at day 14 (p = 0.0072), and more patients reporting low pain intensity (51.5
Objective:To evaluate the effectiveness of the artificial intelligence-based qXR lung nodule malignancy score (qXR-LNMS) in detecting high-risk incidental pulmonary nodules (IPNs) on chest X-rays (CXRs). Patients and Methods:The CREATE (NCT05817110), a prospective, observational study for participants aged 35 years or older with IPN (size, ≥8 to ≤30 mm) on CXR, enrolled 712 participants (high-risk: 498 and low-risk: 214) between April 1, 2023, and December 31, 2024. Participants were flagged by the Food and Drug Administration-cleared qXR detection algorithm and confirmed by radiologists. Threshold for success was set at 20% for positive predictive value (PPV) and 70% for negative predictive value (NPV). The primary and secondary outcomes included PPV and NPV of qXR-LNMS against the risk of malignancy assessed by radiologists using low-dose computed tomography (LDCT) and binarized risk categories based on Lung-RADS score and Mayo Clinic model and PPVs and NPVs by clinicodemographic characteristics with 95% CIs using Wilson score method. Results:Overall, the PPV and the NPV of qXR-LNMS risk prediction against radiologists' assessment on LDCT were 54.2% (95% CI, 49.8-58.5) and 93.5% (95% CI, 89.3-96.1), respectively. The agreement between Mayo Clinic model and qXR-LNMS was observed in 70.6% participants (Spearman correlation, 0.247). Results across key subgroups were consistent with all PPV and NPV point estimates crossing the prespecified threshold. Conclusion:The results demonstrate the potential of qXR-LNMS in predicting benign and malignant IPN on CXR, thereby supporting lung cancer screening, particularly in resource-limited settings, although further validation is needed. Trials Registration:clinicaltrials.gov Identifier: NCT05817110.
Ewing sarcoma (ES) refers to a collection of undifferentiated growths that originate from neuroectoderm cells. The occurrence of ES in the kidneys is exceedingly uncommon. ES of kidney frequently metastasize to various areas of the body. A 21-year-old female presented with complaints of palpable lump in the left hypochondrium since past 3 months associated with intermittent pain and hematuria. Contrast enhanced computed tomography (CECT) revealed heterogeneously enhancing lesion involving entire left kidney associated with pulmonary nodules and pleural effusion. Fluorodeoxyglucose-positron emission tomography computed tomography (FDG PET) scan confirmed lung and liver metastasis. In view of metastatic disease, a percutaneous biopsy of renal mass was performed preoperatively and ES was diagnosed on immunohistochemistry (IHC) and not confirmed before. Neoadjuvant treatment started as per EFT-2001 protocol, which resulted in resolution of distant metastasis and downstaging of tumor. Then the patient underwent laparoscopic left radical nephrectomy and the final Histopathology report (HPR) showed a significant reduction in tumor size with no signs of metastasis. Given the spread of several metastases and the harsh treatment approach, the likelihood of surviving for ES confined to the kidney is improved, although individuals with cancer that has metastasized from the beginning have a reduced survival probability. The neoadjuvant chemotherapy is very effective in ES. The multidisciplinary approach is beneficial in this tumor.
Abstract Background: Infusion therapy forms an integral part of emergency/acute care medicine, and there continue to be many challenges, such as infusion errors, catheter-related complications, infections, medication errors, and occupational health concerns, in the delivery of safe intravenous therapy. Hence, this Society for Acute Care Trauma and Emergency Medicine guideline sought to provide evidence-based recommendations for safe infusion practices in acute emergency situations. Methodology: A systematic Delphi consensus process was undertaken. The operational definitions for safe infusion practice were defined by the steering committee. Evidence was obtained from searches conducted within PubMed/MEDLINE, EMBASE, Cochrane Database, World Health Organization, Centers for Disease Control and Prevention, Infusion Nurses Society, Institute for Safe Medication Practices, Joint Commission and other sources. The strength of recommendation was scored using a five-point Likert scale. Results: One hundred and one recommendations were made within 11 categories, which include training and technology, hand hygiene, difficult venous access, peripheral venous catheter insertion and management, infusion processes, infusion technology, prevention of drug administration errors, waste management, training methods and telemedicine/arteficial intelligence. Sixty-three recommendations had reached a high degree of consensus, 24 reached a medium degree of consensus and 14 were considered weak. A total of 55 recommendations reached consensus in the first iteration of the Delphi process, and 46 needed modification/re-evaluation. The scores of agreement were between 72.4% and 97.2%. Conclusions: The recommendations developed by the current study can serve as a systematic and practical approach to ensure infusion safety in the setting of emergency and acute care.
