Nizam's Institute of Medical Sciences (NIMS) is a public hospital located in Hyderabad, Telangana, India and is named after its founder – the 7th Nizam of Hyderabad– and was inaugurated by Princess Durreshehvar It is an Institute under State Legislature Act under the Act of Andhra Pradesh State Legislature. It has a big sprawling campus in Punjagutta.
Next-generation sequencing (NGS)-based tests are being increasingly employed by clinicians for obtaining a genetic diagnosis in individuals and families with possible genetic disorders. However, there is a significant disparity in the genomic knowledge and skills of the clinicians employing these tests for care and management of families with rare genetic disorders. Through the current document, the Society for Indian Academy of Medical Genetics (SIAMG) aims to provide guidance and consideration in terms of the type of tests available, their appropriate applications, and result interpretation in order to make judicious use of these tests for rare disease diagnosis.
Prenatal diagnosis (PND) is an effective measure to prevent births with transfusion-dependent β-thalassemia (TDT) and other severe hemoglobinopathies. However, multicentric consolidated data from high-volume Indian referral laboratories is limited. The authors collated a multi-center experience of invasive PND for β-thalassemia and the major hemoglobinopathies, including center-wise volumes, affected-fetus rates, trends in primigravida referrals, and diagnostic challenges from seven Indian tertiary-care referral centers with a minimum of 10 y PND services. Retrospective data were contributed by SGRH-New Delhi, ICMR-NIIH-Mumbai, PGIMER-Chandigarh, AIIMS-New Delhi, NIMS-CDFD-Hyderabad, CMC-Vellore and SGPGI-Lucknow. Carrier evaluation was based on blood counts and Hb-HPLC. Fetal diagnosis utilized chorionic villus sampling or amniocentesis with molecular testing by ARMS-PCR, reverse dot-blot and/or Sanger sequencing as per local practices. Descriptive analyses summarized volumes, proportions of fetuses with biallelic HBB variants, and primigravida referral trends. Across centers, 6,780 PND procedures were performed over 2015–2024, with ICMR-NIIH and SGRH contributing 58.2
Cardiomyopathies are a group of diseases involving primary abnormalities of the myocardium, which can be genetically determined or acquired. They are classified as hypertrophic cardiomyopathy, dilated cardiomyopathy, restrictive cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, and unclassified. Biological sex has a great impact on the prevalence, clinical manifestations, and prognosis of cardiomyopathies, through sex hormones, genetic variations, variations in pathobiology, pathophysiology, pharmacogenomics, and socioeconomic factors. The underlying mechanisms are not completely understood. Further research is necessary to understand these mechanisms and develop sex-specific therapeutic targets and treatments. This review aims to provide a summary of the current evidence on sex differences in cardiomyopathies and highlight the knowledge gaps.
Obesity is a global health crisis affecting developing nations, including India. The management of obesity continues to evolve with newer drugs, metabolic and bariatric surgery and endoscopic interventions, requiring family physicians and specialists to adapt their clinical practice accordingly. There is an urgent need for a standardized algorithm to diagnose, stage, and treat obesity. The Endocrine Society of India (ESI) and the Obesity Surgeons Society of India (OSSI) appointed a steering committee to develop an evidence-based algorithm for managing patients with obesity in India. This was put to vote by 80 specialists (38 from OSSI and 42 from ESI) in a physical meeting. A proposed stage-wise algorithm based on Edmonton Obesity Staging System, Asian definition of obesity, and resources in India, received 100
Cite this article as: Tiwari Ankit, M Niranjan, B VijayChander, Balaji KS, Muvva Srija, G Swarnalatha. Extensively drug-resistant Klebsiella pneumoniae peritonitis: a rare case of dual NDM and OXA-48 carbapenemase production. Turk J Nephrol. Published online February 24, 2026. doi: 10.5152/turkjnephrol.2026.251209
