Chemoradiotherapy followed by surgery and adjuvant chemotherapy is standard treatment for locally advanced rectal cancer. The approach of total
In chronic cluster headache (CH), as opposed to episodic CH, the attacks occur year-round. Chronic CH is also harder to treat, highlighted by recent
Concerns are growing that immune responses induced by natural infection or vaccines may be less effective against SARS-CoV-2 variants such as B.1.351
Previously identified risk factors for treatment failure for community-acquired pneumonia (CAP) included advanced age, smoking, malnutrition, and
Thus far, two SARS-CoV-2 mRNA vaccines have received Emergency Use Authorization, and two adenovirus-vectored vaccines are in phase 3 studies. In an
Patients with dementia are at excess risk for harms related to polypharmacy, such as falls and impaired cognition. Polypharmacy among dementia patients
The prior IDEA collaboration — a prospective, pooled analysis of six international trials — provided support for the use of shorter-duration (3 vs. 6
Studies with various limitations generally have shown that high sodium intake and low potassium intake are associated with higher risk for hypertension
The effects of cardiovascular medications in general patient populations do not necessarily translate to patients with end-stage renal disease (ESRD).
Estimation of the glomerular filtration rate (GFR) generally is based on serum creatinine, age, and sex — and incorporates an adjustment for race
Evidence suggests that, in a patient with acute appendicitis, presence of an appendicolith is associated with worse outcomes (e.g., abscess,
Untreated, severe eosinophilia (i.e., absolute eosinophil count >5000 cells/μL) can result in organ damage, which makes prompt recognition and
Coronary artery calcium (CAC) can help to predict risk for adverse cardiovascular (CV) events. In this analysis of a large South Korean cohort of
Patients' responses to drug therapies for painful knee and hip osteoarthritis (OA) are unpredictable and often disappointing. In this network
The mainstay of treatment for patients with peripheral arterial disease and intermittent claudication is exercise, smoking cessation, and management of
Sodium–glucose cotransporter-2 (SGLT-2) inhibitors have emerged as efficacious therapies that decrease adverse outcomes in patients with heart failure
Cervical artery dissection is a common cause of stroke in adults younger than 50 years, yet the optimal antithrombotic regimen to prevent recurrent
Formal diagnosis of nonalcoholic fatty liver disease (NAFLD) requires imaging or biopsy. However, scores to predict risk for NAFLD, based on clinical
Reducing dietary sodium, in combination with increasing dietary potassium, can lower blood pressure (BP) in some “salt-sensitive” people. To examine
Clinical trials have reported efficacies >94% for mRNA SARS-CoV-2 vaccines in preventing symptomatic disease, with lower efficacy against infection. As
