Abstract This study assessed the pharmacological prospects of Pteridaceae phytoconstituents using an integrated network pharmacology (NP) and computational molecular docking (MD) strategy. Various peer-reviewed literature databases, including ScienceDirect, PubMed, Scopus, and Google Scholar, were used to gather bioactive constituents reported from this family. Absorption, Distribution, Metabolism, Excretion and Toxicology (ADMET) parameters, drug-likeness rules, and bioavailability scores were evaluated using SwissADME software, while toxicity profiles were predicted using ProTox-3.0. Potential targets of each compound were identified using Swiss Target Prediction software. Breast cancer–specific genes were obtained from OMIM (Online Mendelian Inheritance in Man), UniProt, CTD (Comparative Toxicogenomic Database), PharmGKB, and GeneCards. NP tools were employed to identify common targets between drugs and diseases, construct a protein–protein interaction (PPI) network, and perform Gene Ontology (GO) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analyses. Finally, MD analysis was performed to determine the binding efficiency of selected compounds with hub genes, thereby validating their potential activity. The study identified 143 predicted targets for six Pteridaceae-derived compounds, along with 12,120 breast cancer–associated targets retrieved from multiple databases. Comparison yielded 139 overlapping protein targets (4 of which showed low interaction scores), which were subsequently mapped into a PPI network consisting of 135 nodes and 683 edges. KEGG-based pathway and GO enrichment analyses revealed 111 signaling pathways, 86 biological processes, 22 cellular components, and 20 molecular functions. KEGG pathway analysis identified the interleukin-17 pathway as significantly enriched. MD analysis showed that pterosin J exhibited the highest binding affinities among the six compounds tested, with docking scores of −7.4, −7.3, −7.3, and −6.7 kcal/mol against PTGS2, HSP90AA1, GSK-3β, and MAPK3, respectively. The present bioinformatics study suggested that pterosin J may have anticancer potential against breast cancer. Further in vitro and in vivo experiments are suggested to confirm the potential of the compound.
Abstract Ramadan fasting (RF) is a globally practiced, month-long religious fast characterized by complete abstinence from food and fluid intake from dawn to sunset. Unlike secular intermittent fasting, RF occurs within a structured behavioral and cultural framework that shapes metabolic and physiological adaptation. RF induces coordinated metabolic adaptations, including increased lipid oxidation and preservation of glucose homeostasis, with generally neutral to favorable effects on cardiometabolic risk markers. Circadian and hormonal changes reflect adaptive realignment to nocturnal feeding patterns rather than dysfunction. Nutritional quality, hydration, and behavioral factors during non-fasting hours emerge as primary determinants of health outcomes. RF represents a model of integrated metabolic and behavioral adaptation in which outcomes are driven by dietary quality, hydration, and sustained lifestyle behaviors beyond Ramadan.
Abstract Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic inflammatory disease. RA mainly affects the synovial membrane of the joints and surrounding tissues. Disease progression can lead to joint deformities, which restrict mobility and contribute to reduced muscle strength. The aim of this study was to identify, critically evaluate, and systematically synthesize all available scientific evidence on the effectiveness of endurance exercise combined with muscle strength training (ST) in RA. Indexed databases were included, such as PubMed, Web of Science, Embase, Scopus, Latin American and Caribbean Health Sciences (LiLACS), Cochrane, as well as gray literature databases: Google Scholar, Open Gray, and ProQuest. There were no limitations on period or language. The risk of bias was assessed using the Cochrane Risk of Bias 2 tool by two independent reviewers. The primary outcome was muscle strength and secondary outcomes were functional incapacity, disease activity, and quality of life. Initially, 1.605 records were found, 1,461 in the main databases and 144 in the gray literature. Four studies were included in this review. Supervised programs, lasting 8 to 24 weeks and with an intensity between 40 to 80% of 1RM and 60 to 80% of HRmax, showed significant improvement in muscle strength (gains of 15–35%) and reduction in disease activity, without inflammatory exacerbation. There was also a decrease in functional disability (mean reduction of 0.42) and a trend toward improvement in quality of life. Combined endurance and ST, applied at moderate to high intensity (40–80% of 1RM; 60–80% of HRmax), proved effective for patients with RA, promoting increased muscle strength, functional improvement, and reduced disease activity without aggravating the inflammatory process.
Abstract These are the abstracts of the free communications of the Libyan Diabetes Association (LDA) Scientific Conference, December 18 to 20, 2025, Tripoli, Libya. They are presented here to reach a wider audience. These studies represent all research accepted by the research evaluation committee; all of them are in the field of diabetes and its complications, or the use of modern technologies and artificial intelligence in diabetes. They include observational studies, experimental exercises, and a few case reports. The aim of publishing these abstracts is to spread knowledge and foster fruitful communication between researchers in Libya and abroad, even before the presented research is fully published.
