SARS coronavirus 2 (SARS-CoV-2) in the viral spike (S) encoding a SARS-COV-2 SPIKE D614G mutation protein predominate over time in locales revealing the dynamic aspects of its key viral processes where it is found, implying that this change enhances viral transmission. It has also been observed that retroviruses infected ACE2-expressing cells pseudotyped with SG614 that is presently affecting a growing number of countries markedly more efficiently than those with SD614. The availability of newer powerful computational resources, molecular modeling techniques, and cheminformatics quality data have made it feasible to generate reliable algebraic calculations to design new chemical entities, merging chemicals, recoring natural products, and a lot of other substances fuelling further development and growth of this AI-quantum based drug design field to balance the trade-off between the structural complexity and the quality of such biophysics predictions that cannot be obtained by any other method. In this paper, we strongly combine topology geometric methods targeting at the atomistic level the protein apparatus of the SARS-COV-2 virus that are simple in machine learning anti-viral characteristics, to propose computer-aided rational drug design strategies efficient in computing docking usage, and powerful enough to achieve very high accuracy levels for this in-silico effort for the generation of the AI-Quantum designed molecule the RoccustyrnaTM small molecule, a multi-targeting druggable scaffold (1S,2R,3S)‐2‐({[(1S,2S,4S,5R)‐4‐ethenyl‐4‐sulfonylbicyclo[3.2.0]heptan‐2‐yl]oxy}amino)‐3‐[(2R,5R)‐5‐(2‐methyl‐6‐methylidene‐6,9‐dihydro‐3H‐purin‐9‐yl)‐3‐methylideneoxolan‐2‐yl]phosphirane‐1‐carbonitrile targeting the COVID-19-SARS-COV-2 SPIKE D614G mutation using Chern-Simons Topology Euclidean Geometric in a Lindenbaum-Tarski generated QSAR automating modeling and Artificial Intelligence-Driven Predictive Neural Networks.
Scientific developments have enhanced the capacity to synthesize unique particulates in the size range of 1 to 100 nm, increasing interest in nanotoxicology and nanoscale particulates (NPS). As part of the study of ultrafine particles, the toxicology of certain NPs has been studied for a long time. NPS, which are components of pollutants from combustion and dust-producing manufacturing processes, are ultrafine particles.
MATNANO 2021 aims at sharing new ideas and new technologies amongst the professionals, industrialists, and students from research areas of Advanced Materials and Nanotechnology to share their recent innovations and applications and indulge in interactive discussions and technical sessions at the event. The Conference will also have a space for companies and/or institutions to present their services, products, innovations and research results. MATNANO 2021 and Nanotechnology involves the tracks like Advanced Materials and Functional Devices, Engineering Materials, Composite Materials, Nano Medicine to Reveal Signs of Disease, Magnetism and Multiferroism, Areas of Nanoscience Research in Agriculture and Food Science, Optical materials and plasmonics, Energy and Harvesting Materials, Nanotechnology-Basics to applications, Nanopore science, Nanomedicine, Bio Nanotechnologies, Carbon nanostructures and graphene, Spintronics, Nanoparticle synthesis, and applications.
A new extreme acute respiratory syndrome coronavirus 2 (nCoV or SARS-CoV-2) emerged in December 2019 and quickly developed into a global pandemic, which was announced on March 2020. Though treatment options are still limited, medical and science experts have been working together to develop effective therapies that will reduce the pandemic's severity. Viruses are naturally occurring nanoparticles that run at the same metric scale as other nanomaterials. For years, the nanomedicine community has worked hard to mimic virus behaviour by creating viral-like nanoparticles that can be used for targeted therapy and gene delivery. It's not shocking, then, that nanotechnology techniques have proven to be extremely useful in the current pandemic, with applications ranging from viral neutralisation and identification to vaccine production and treatment. Using nanotechnology platforms, a new class of DNA and RNA based vaccines delivers the genetic sequence of unique viral proteins to host cells. Traditional vaccines, on the other hand, elicit immune responses by injecting whole viruses into the body, such as attenuated live viruses, inactivated viruses, or engineered viruses. In clinical trials, both forms of vaccines are being tested against COVID19 mRNA based treatments have a number of benefits over other methods. Since mRNA is not infectious and cannot be inserted into the host genome, it is a better option than whole virus or DNA transmission.
Nanotechnology is been constantly proving its worth in all kinds of different fields. Among them, its prominent role can be seen in world medicine (pharmaceutical research). The researchers claim that these integrations of nanotechnology in the field of medicine can help us solve many mysteries and help us to reach a new level of innovative medical solutions.
About conference Conference Series LLC LTD, the world’s leading Scientific Event Organizer invites all the Speakers, Delegates, Researchers, Students and Industrialists to attend the 32nd World Nano Conference (Nano 2021) during October 25-26, 2021 around the theme Scrutinizing the latest approaches in the sphere of Nanotechnology. Following the success of previous Nano Conference held during November 24, 2020 we are now delighted to welcome you to 32nd World Nano Conference (Nano 2021) during October 25-26, 2021 aimed to provide an opportunity for all the Attendees to meet, interact and exchange new ideas in the various areas of Nanotechnology.
On behalf of the Board of Journal of Nanomaterials & Molecular Nanotechnology survey and co-editors, I am glad to present Volume 10, Issue 5 of the journal. It is an open-access peer-review journal in the field of nanomaterials and molecular nanotechnology. Journal of Nanomaterials & Molecular Nanotechnology survey (JNMN) is having International Standard Serial Number (ISSN): 2324-8777.
Despite recent breakthroughs in clinical research, clinics confront a tremendous challenge in finding appropriate therapeutic options to address a variety of ailments. The majority of today's therapeutic drugs are water-insoluble, resulting in low bioavailability, minimal action at the illness site, and severe therapy-related adverse effects. Scientists from around the world are working around the clock to fix these challenges and improve the treatment's therapeutic benefits. In recent years, there has been an unanticipated increase in nanotechnology research. Nanotechnology's use in medication and gene delivery has grown in popularity in health care and other industries during the last several decades. Nanotechnology's application in medicine is gaining traction as a promising tool for cancer detection, treatment, and prevention. Growing interest in nanotechnology's potential medical uses has spawned a new discipline known as nanomedicine, which aims to maximise therapeutic index, dramatically extend human longevity, and reduce unpleasant side effects. Countless nanomedicines have been developed to treat diseases such as cancer, diabetes, and neurodegenerative disorders using diverse organic and inorganic materials like as lipids, polymers, metals, or their mixtures with the appropriate physicochemical properties and biological functionalities. To circumvent biological barriers via the increased permeability and retention (EPR) effect, physicochemical factors such as particle size, shape, surface charge, and surface ligand distribution must be tuned utilising improved chemical procedures. Nano formed medications have better pharmacokinetics than free pharmaceuticals, such as a longer half-life in the circulation and enhanced, increased drug concentration at the disease site, and decreased normal tissue toxicity. Only a few nano-formulated medications have been approved by the FDA since the mid-nineties, such as Doxil (a liposomal formulation of doxorubicin), the first nanomedicine licenced for cancer treatment in 1995. Abraxane (albumin-bound paclitaxel formulation) was approved in 2005 for the treatment of solid tumours, mostly due to its reduced adverse effects. The FDA recently approved ONIVYDETM (Irinotecan liposome injection) for the treatment of metastatic pancreatic cancer after gemcitabine treatment. Despite substantial advancements in nanotechnology, few authorised nano-formulated medications are available. In-depth characterization is frequently portrayed as a translational bridge that every candidate must cross. A complete and well-documented classification of each substance is the most dangerous phase in nanomedicine evaluation. Its biological inquiry can be readily misunderstood without a thorough grasp of the nanoformulations. To avoid delays in clinical testing, each preparation's physical, chemical, and biological characteristics must be thoroughly evaluated. According to our observations, there is a gap in our understanding of the complexities of developing nanotechnology-based medicines. For each application, a variety of physical and chemical features, such as nanoparticle size, charge, surface chemistry, and hydrophobicity, must be fine-tuned, and this process necessitates a set of skills and technologies that must often be developed iteratively. In the field of nanomedicine, for example, the formula one size does not fit all must be considered.
Nanotech Expo 2021 invites all the experts and researchers from the Nanotechnology and Materials Engineering sector all over the world to attend “ 2nd World Congress on Nanotechnology and Advanced Materials “(Nanotech Expo 2021)., wihich is going to be held on Nov 08-09, 2021 at Paris , France Nanotech Expo 2021 conference includes Keynote presentations, Oral talks, Poster Presentations, Workshops, and Exhibitors. Nanotechnology and Materials Engineering are forthcoming use in healthcare, electronics, cosmetics, and other areas. Nanomaterials are the elements with the finest measurement of size 10-9 meter. The theme of the conference is about “To explore the implications and innovations of nanotechnology and advanced materials to better lives”.During the conference International symposiums, Panel Discussion and B2B meetings are organized and also International workshops are conducted based on the specific topics related to Nanotechnology and Materials Engineering. The properties of many materials change when the size scale of their dimensions approaches nanometers is the foremost interesting things about nanotechnology. Materials scientists work to apprehend those property changes and utilize them in the processing and manufacture of materials at the Nanoscale. The field of materials science covers the discovery, characterization, properties, and quit-use of Nanoscale materials. The most other engineering majors work with Nanotechnology, but the heart of nanotechnology is Materials Science and Materials Engineering across all the disciples. Nanotech Expo 2021conference is also comprised of Best Post Awards, Best Oral Presentation Awards, Young Researchers Forums (YRF) and also Video Presentation by experts. We are glad to welcome you all to join and register for the “2nd World Congress on Nanotechnology and Advanced Materials “(Nanotech Expo 2021) which is going to be held on November 08-09, 2021 Paris, France.
Under resonant excitation, nanoparticles such as noble metal nanomaterials and various metal oxide nanomaterials display extremely strong light-matter interactions. At targeted wavelengths, very high absorption and scattering can be obtained. Optical NPs and nanostructures have been widely exploited in a variety of sectors, including nanophotonics and analytical chemistry, due to their appealing optical features. Five original research articles are presented here, each addressing a different aspect of optical nanomaterials synthesis, an innovative optical sensor design, and energy storage. In addition, novel physical phenomena and mechanisms are described in these disciplines. Dr. S. R. Tahhan and colleagues described the creation of a fibre Bragg grating coating for refractive index sensors using TiO2 nanostructured metal oxide. After coating the fibre with a few hundreds nanometers thick TiO2 coating with 20 nm–50 nm hole sizes, higher shifts and narrower peaks in the Bragg wavelength were produced. The sensitivity of the sensor with TiO2 coating is higher than that of the sensor without it. Dr. G. Zhu studied the mode structures of a multiphoton generated UV laser in a ZnO microrod. The vapor-phase transport approach was used to make hexagonal wurtzite structural ZnO microrods. The multiphoton induced ultraviolet (UV) laser was seen in a microrod under the excitation of a pulse laser with a wavelength of 1200 nm. The laser mode structures' reliance on the pump. At low pump intensity, the laser is in whispering gallery mode (WGM), while at high pump strength, it is in Fabry-Perot (FP) mode. Dr. Q. Liu and colleagues have published another paper on the regulated growth of ZnO nanorod arrays. The seed layer of ZnO nanoflakes on Al substrates is used to create high-quality ZnO nanorod arrays. This transition is thought to be caused by the physical adsorption of water molecules on the surface of ZnO nanorod arrays, as proven by X-ray photoelectron spectroscopy.
I'm happy to say that during the year 2021, all issues of volume 9 were successfully published online; expressing views of world’s eminent researches. The Impact factor of Journal of Nanomaterials & Molecular Nanotechnology for the year 2020 was 3.761.
Conference Series invites all the participants from all over the world to attend “World Congress on Advanced Nano Research and Nano Tech Applications'’ during September 07-08, 2021 Webinar. Which includes prompt keynote presentations, Oral talks, Poster presentations and Exhibitions? welcomes all the Nano Technologists, Electronic Engineers, Researchers, Industrialists, Young Scientists as well as Student and Corporate delegates across the world to participate in the event and to have a great experience. The theme of the conference is based on “Cutting edge research in Nano Science and Nano Technology”. International symposiums, B2B meetings, international workshops will also be organized to discuss the specific topics in the field of Nano technology during the conference. We also welcome International Exhibitions form corporate sectors to showcase the recent advancements in the tools and techniques
Green synthesis of Ag-NPs (silver nanoparticles) has revolutionized the area of nanotechnology consistently and bio-based silver nanoparticles have emerged as efficient therapeutic tool in the field of biomedical science. The nanoparticles were synthesized via green route approach by Urtica dioica leaf extract. The biosynthesized Ag Nanoparticles (NPs) were analyzed by Powder XRD, FTIR, SEM with EDX, UV-vis and HRTEM analysis. The antimicrobial studies of the synthesized Ag-NPs were tested against Bacillus subtilis, and Staphylococcus aureus (gram-positive) and Psuedomonas aeruginosa, and Shigella dysenteriae (gramnegative) bacterial pathogens using the disc diffusion method. The prepared nanoparticles demonstrated strong antimicrobial activity against all microbial strains examined with varying concentrations.
Curcumin, a polyphenolic pigment found in turmeric, has tremendous medicinal potential, but it has yet to be developed as a medication due to its poor water solubility and metabolic instability. Curcumin can remain in keto-enol tautomeric forms depending on ambient pH, according to structural analyses. Curcumin, a polyphenolic pigment found in turmeric, has tremendous medicinal potential, but it has yet to be developed as a medication due to its poor water solubility and metabolic instability. Curcumin can remain in keto-enol tautomeric forms depending on ambient pH, according to structural analyses. The keto form is formed at an acidic pH, and the presence of the -diketone motif in the molecule activates the methylene group, allowing it to donate a hydrogen atom to reactive oxygen species, resulting in its anti-oxidative capabilities. Because of substantial delocalization of electrons from one aromatic ring to the other through the pi orbital of C=C bonds in the heptadione linkage, the enol form of curcumin, which is present at alkaline pH, forms a planar molecule. Curcumin is degraded to smaller molecules at alkaline pH, which have been proven to have therapeutic potential. The methylene group in the -diketone domain, as well as the methoxy and phenoxy groups on the aromatic rings of curcumin, have been identified as contact locations with enzymes and signalling molecules, and may be involved in inactivating them, according to molecular interaction studies. Turmeric, made from the rhizome of the Curcuma longa plant, has long been used in Indian traditional medicine for wound healing, pain relief, and antibacterial purposes. However, no one knew what the bioactive component of turmeric was until Vogel Jr. extracted the yellow pigment in its pure form in 1842. Milobedzka and Lampe elucidated its chemical structure and named it curcumin as a result of this. Following that, Srinivasan's fractionation in 1953 revealed that it was made up of three separate molecules: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. A fourth molecule, cyclocurcumin, has recently been discovered utilising improved chromatographic techniques, compatible resins, and solvent systems.
Because the optical properties of gold nanoparticles are programmable as a function of size and shape, they have spawned an emergent platform of nanogold-based devices for a variety of applications. The radiolytic synthesis, among the known procedures for the synthesis of gold nanoparticles, offers proper control of the nucleation process without the use of reducing agents, in a single step, combined or not with simultaneous sterilisation. This paper examines and describes the use of radiation technologies in the synthesis and preparation of gold nanoparticles, with a focus on fundamental features of synthesis and radiation sources, as well as final applications for nanogold-based systems.
Mobile devices rely on energy storage, and there is a constant desire for smaller, yet more powerful batteries. Over the years, a lot of work has gone into researching new electrode materials, electrolytes, cell topologies, and fabrication methods in order to improve the electrochemical performance of batteries while lowering manufacturing costs. Simultaneously, 3D printing is transforming our society, and the technology is rapidly improving. It is quickly becoming the foundation for next-generation futuristic 3D printed energy systems, in which batteries and super-capacitors may be printed in nearly any shape. Manufacturers have had to design their products around the size and shape of commercially available batteries, which currently occupy the majority of space in modern electronic devices. The majority of them are cylindrical or rectangular in shape and are designed for coin and bag cells. As a result, when a producer designs a product, the battery must be a specific size and shape, thus wasting space and limiting design alternatives. This is increasingly posing a design challenge for future generations of flexible electronics. lithography-based 3D printing, template-assisted electrodeposition-based 3D printing, inkjet printing, direct ink writing, fused deposition modelling, and aerosol jet printing, among others, are all examples of 3D-printed batteries using various printing techniques. The authors also go into the operating principles, printing process, benefits, and drawbacks of each 3D printing technology, as well as the printing materials for the printed batteries' electrodes and electrolytes. 3D printing is an advanced production technology that uses digitally controlled deposition of phase change and reactive materials, as well as solvent-based inks, to produce complex 3D structures. This kind of fabrication usually starts with the creation of a 3D virtual model that is then cut into many 2D horizontal cross sections with the use of specific software. A cohesive 3D object can be produced by successively printing fresh 2D layers on top of prior levels.
Scientists and engineers have focused their research in recent years on the creation of nanomaterials and their applications in several fields. Nanoparticles are used in a wide variety of fields, including engineering and medicine. Nanoparticles can be used in environmental applications as well. Nanomaterials have unique features as a result of their small size. They are excellent catalysts due to their large surface area. Catalysts, sensors, coatings, adsorption, and drug delivery are some of the most common chemical engineering applications. Despite the numerous benefits, the most important task is to prepare and maintain the right size of nanomaterials. Chemical engineers are critical to the advancement of nanomaterials. The purpose of this paper is to explain the various nanomaterials, their applications, and their preparation processes. In this overview, the outcomes of numerous patents and research publications have been summarise
Molecular Dynamics had come up with the motivation for analyzing of fluid dynamics, other specific phenomena of fluid or thermal mechanics. As computational analyzing capability has been continuously rising up, this techniques and methods also have been expanding over possible fields with material science, related fields with quantum dynamics and science as well [1]. Recently it is to be applicable for possible material phenomena estimation as computer hardware technology is going on further advance [2]. This case study report includes the application for parts production Equipment with possible IT applications and also positive application of mathematical solutions with embedded system application.
The key to the nanotechnology revolution is the controllable manufacturing of materials/devices at the micro- and nanoscale, which is backed up by enhanced characterization. We have made nanotechnology a reality, compared to decades before when it was confined to the literature. Some sectors, such as silicon chip manufacture, have been affected by the nanoeffect and are attempting to avoid it. The key to the nanotechnology revolution is the controllable manufacturing of materials/devices at the micro- and nanoscale, which is backed up by enhanced characterization. We have made nanotechnology a reality, compared to decades before when it was confined to the literature. Some sectors, such as silicon chip manufacture, have been affec
First and foremost, we'd want to express our heartfelt gratitude to the Open Access Journal's editors. The Journal of Nanomaterials and Molecular Nanotechnology works with over 50 distinguished editors and publishes high-quality articles in the field of Nanoscience and Nanotechnology which includes topics such as Nanomaterials, Types, Design, Synthesis & Characterization of Nanostructured Materials, Current Research Advancements, Potential applications of Nanomaterials/Nanotechnology, Global Market, Molecular Nanotechnology, Nanodevices and Nanosensors, Nanoelectronics, Nanomedicine, Nanofabrication Techniques, Nanotoxicity, Nanobiotechnology, Pharmaceutical Nanotechnology, Commercial Aspects-Nanotechnology Market, etc. We use an Editorial Tracking System, an online manuscript submission, review, and tracking system, to ensure excellence in the peer-review process.
