Objective To explore the effectiveness of an image recognition system based on artificial intelligence(AI)in diagnosing benign and malignant endometrial cell clumps.Methods We selected endometrial cytological specimens from The First Affiliated Hospital of Xi'an Jiaotong University and Xi'an Daxing Hospital from August 2021 to February 2023;histopathology was used as the gold standard.We compared and analyzed the sensitivity,specificity,positive predictive value,negative predictive value,accuracy and diagnostic time of AI image recognition system(AI diagnosis)and professional pathologists'manual diagnosis(manual diagnosis)of benign and malignant endometrial cell clumps.Results Among the 126 patients included in the analysis,the overall coincidence rate of AI diagnosis and histological diagnosis was 92.1％(116/126),which was highly consistent with histopathological results(Kappa=0.841).The overall coincidence rate of manual diagnosis and histological diagnosis was 94.4％(119/126),which was highly consistent with histopathological results(Kappa=0.889).There was no statistically significant difference between AI diagnosis and manual diagnosis methods(x2=0.568,P=0.451).The sensitivity,specificity,positive predictive value,and negative predictive value of AI diagnosis were 91.8％,92.3％,91.8％,and 92.3％,respectively.There were 126 cytology sections,each of which required 6.67 minutes for manual diagnosis and 5.00 minutes for AI diagnosis.Conclusion The AI image recognition system has high diagnostic accuracy,sensitivity and specificity,which is equivalent to the manual diagnosis level of professional pathologists.Therefore,this system has application value in the diagnosis of benign and malignant endometrial cell clumps.
Uromodulin, also named Tamm Horsfall protein, have been associated with renal function and sodium homeostasis regulation. The authors sought to examine the effects of salt intake on plasma and urinary uromodulin levels and the association of its genetic variants with salt sensitivity in Chinese adults. Eighty patients from our natural population cohort were maintained sequentially either on a usual diet for 3 days, a low‐salt diet (3.0 g) for 7 days, and a high‐salt diet (18.0 g) for an additional 7 days. In addition, the authors studied 514 patients of the Baoji Salt‐Sensitive Study, recruited from 124 families who received the same salt intake intervention, and investigated the association of genetic variations in uromodulin gene with salt sensitivity. Plasma uromodulin levels were significantly lower on a high‐salt diet than on a baseline diet (28.3 ± 4.5 vs. 54.9 ± 8.8 ng/ml). Daily urinary excretions of uromodulin were significantly decreased on a high‐salt diet than on a low‐salt diet (28.7 ± 6.7 vs. 157.2 ± 21.7 ng/ml). SNPs rs7193058 and rs4997081 were associated with the diastolic blood pressure (DBP), mean arterial pressure (MAP) responses to the high‐salt diet. In addition, several SNPs in the uromodulin gene were significantly associated with pulse pressure (PP) response to the low‐salt intervention. This study shows that dietary salt intake affects plasma and urinary uromodulin levels and that uromodulin may play a role in the pathophysiological process of salt sensitivity in the Chinese populations.
Objective To estimate the prevalence, associated factors and patterns of multimorbidity of non-communicable diseases among adults in Shaanxi Province so as to provide evidence for the prevention and control of non-communicable diseases. Methods We used the data of adults aged 18 years and older collected in the baseline survey of Shaanxi Project in the Regional Ethnic Cohort Study in Northwest China. Multinomial logistic regression was used to explore the associated factors for multimorbidity. Exploratory factor analysis was used to extract patterns of multimorbidity. Results The prevalence of multimorbidity was 10.7% among the 44 442 participants.Age increase,being males,urban residence,and being overweight or obesity were positively associated with multimorbidity.Compared with women,men had a higher risk of multimorbidity.The ORand95% CI was 1.25（1.12-1.39）.The risk of multimorbidity increased with age among adults.Compared with participants aged18.0-34.9years,the ORs and 95% CIs of those aged35.0-44.9,45.0-54.9,55.0-64.9,and≥65.0years were 4.73（3.47-6.46）,15.61（11.60-21.00）,41.39（30.76-55.70）and 90.04（66.58-121.77）,respectively.The primary multimorbidity patterns among adults in Shaanxi were cardiovascular-metabolic multimorbidity（5.4%）,visceroarticular multimorbidity（1.0%）,and respiratory multimorbidity（0.3%）.Conclusion More than one in ten adults in Shaanxi Province had multimorbidity,and the predominant pattern of multimorbidity was cardiovascularmetabolic multimorbidity.The prevention and control of non-communicable diseases should be reinforced in middleaged and older people,males,people living in the urban,and overweight or obese people.More attention should be paid to the prevention and control of cardiovascular-metabolic diseases.
目的 探讨选择性神经损伤(selective nerve injury,SNI)模型所致神经病理性疼痛对C57 小鼠肠道菌群多样性的影响.方法 将 36 只C57 小鼠进行随机分组,分别为 SNI 模型组、假手术组和对照组(n 分别为 18、8、10).分别在造模后 0、1、3、7、14 d进行机械刺激痛阈和热痛敏测试;在造模后第 14 天取所有小鼠结肠末端内容物(新鲜粪便)分析其肠道菌群多样性.结果 造模后 1 d,SNI模型组小鼠由于神经损伤致机械刺激痛阈较造模前显著下降(超过70%)、热痛敏阈值下降 40%,而假手术组和对照组无显著下降,SNI模型组表现为患足痛觉过敏,与假手术组和对照组相比,差异具有统计学意义(P<0.001);假手术组在造模后第 1 天热痛敏阈值较对照组出现短暂下降(P=0.006),但第 3 天之后两组间痛阈变化无差异.α-多样性分析显示,SNI 模型组肠道菌群 Observed、Chao1、ACE 和 Simpson等丰度明显低于对照组(P<0.05),即 SNI模型组由于疼痛刺激出现了菌群紊乱;而假手术组肠道菌群各丰度均低于对照组(P<0.05),下降变化介于 SNI模型组和对照组之间.结论 SNI 模型所致神经病理性疼痛导致 C57 小鼠机械刺激痛阈和热痛敏阈值下降,使其肠道菌群多样性降低.
目的 综合比较奇神经节射频热凝和脉冲射频治疗原发性会阴痛的治疗效果.方法 分析 2020 年 1 月至2022 年 3 月行奇神经节射频热凝(A 组)和脉冲射频(B 组)治疗的 79 例原发性会阴痛患者,评价术前、术后 24 h、1 周、1 个月、3 个月和 6 个月的疼痛程度(VAS)、优良率、睡眠质量(PSQI)、术后口服药物、并发症及复发情况,比较两组间的差异.结果 A组 VAS评分在术后随访各节段呈现逐渐下降趋势,B组 VAS评分在术后 24h下降之后又逐步增加.A组 VAS评分在术后 1 周开始低于B组(P<0.05),且随着时间的延长组间差异进一步增加(P<0.001).在随访6 个月后,A组优良率(86%)明显高于B组(22%).除了术后会阴区皮肤麻木外,A 组在改善睡眠、术后口服用药(普瑞巴林和阿片类)和病情复发方面均优于B组(P<0.05).结论 奇神经节射频热凝能够通过减轻疼痛、提高优良率、改善睡眠、降低复发及减少用药来提高生活质量,效果优于脉冲射频.
