Objective: In combination with Maximum Standardized Uptake Value (SUVmax) from SPECT/CT scans in lung cancer patients, serum alkaline phosphatase (ALP), molecular fragments in the N end of osteocalcin (N-MID), total procollagen type 1 N-terminal propeptide (TPINP), and bone mineral density (BMD) measurements to explore the clinical early diagnosis of lung cancer bone metastasis. Methods: A total of 107 patients diagnosed as lung cancer at a tertiary-level Class A hospital between January 2021 and June 2022 were enrolled, comprising 37 cases with bone metastasis and 70 cases without bone metastasis. All patients underwent relevant examinations. SPECT/CT was performed in the supine position with anterior and posterior whole-body bone imaging, using a matrix of 256 × 1,024, an energy peak of 140 keV, and a window width of 20%. SUVmax was measured. BMD measurement utilizes dual-energy X-ray absorptiometry to assess the first to fourth lumbar vertebrae, bilateral femoral necks, and total hip joints in the examinees, yielding bone mineral content per unit area (g/cm2). Fasting blood samples in the morning were taken and a fully automated biochemical analyzer was used to measure ALP levels, and a fully automated chemiluminescence immunoassay analyzer was used to measure serum N-MID and TPINP levels. Results: Patients with bone metastasis exhibited ALP, N-MID and TPINP levels of 120.30 ± 33.32 U/L, 19.03 ± 3.54 mg/L and 82.21 ± 26.65 mg/L, respectively, significantly higher than those in patients without bone metastasis (94.43 ± 30.30 U/L, 15.50 ± 4.01 mg/L, 55.58 ± 21.01 mg/L), p < .001, indicating a significant difference; The lumbar spine BMD in patients with bone metastasis was 0.82 ± 0.12 g/cm2, compared to 0.89 ± 0.14 g/cm2 in patients without bone metastasis, p = .011, demonstrating a statistical significance. Comparisons between patients with and without bone metastasis revealed no statistically significant differences in gender, pathological type, femoral neck BMD, or whole-body BMD (p > .05). The SUVmax value for adenocarcinoma patients was 11.45 ± 1.98, significantly lower than 13.51 ± 2.00 for patients with squamous cell carcinoma and 13.98 ± 2.02 for other types (p < .001), representing a statistically significant difference. For patients with tumors with diameter > 5 cm and TNM stage III–IV, SUVmax values were 13.38 ± 1.95 and 12.99 ± 2.00, respectively, significantly higher than those with tumors ≤ 5 cm (11.50 ± 2.01) and TNM stage I–II (11.77 ± 1.93), with p < .001 and p = .002, respectively, demonstrating a statistical significance. Comparison in SUVmax of gender and age showed p > .05, indicating no statistically significant difference. In patients with TNM stage III–IV, ALP, N-MID and TPINP levels were 110.39 ± 21.12 U/L, 18.62 ± 2.22 mg/L and 70.31 ± 17.02 mg/L, respectively, significantly higher than those in patients with TNM stage I–II (97.45 ± 19.82, 15.12 ± 2.14 and 60.12 ± 15.65, respectively. The corresponding p values were .001, < .001 and .002, indicating a statistical significance. Comparison in ALP, N-MID and TPINP levels among patients of different genders, ages, pathological types and tumor diameters showed p > .05, indicating no statistically significant differences. The areas under the ROC curves for ALP, N-MID and TPINP in the diagnosis of bone metastasis were 0.695, 0.734 and 0.837, respectively, with p < .05. Conclusions: Serum ALP, N-MID and TPINP levels were significantly elevated in patients with bone metastasis of lung cancer in comparison to those without bone metastasis, while SUVmax showed no significant difference. SUVmax, ALP, N-MID and TPINP are associated with certain clinical and pathological characteristics in lung cancer patients. Among these, ALP, N-MID and TPINP demonstrate a potential diagnostic value for detecting bone metastasis in lung cancer.
Objective: Under the support of visual ultrasound technology, this study investigates the efficacy of the combination of betamethasone and platelet-rich plasma (PRP) injections for the precise treatment of frozen shoulder. The findings aim to inform clinical practice. Methods: A total of 84 patients with frozen shoulder who visited the outpatient department of a tertiary Class A hospital between January 2021 and June 2023 were selected. They were randomly assigned to receive either local betamethasone injection guided by visual ultrasound technology or combined betamethasone and PRP injection for precise treatment. The betamethasone local injection group comprised 42 patients, while the combined betamethasone and PRP injection group comprised 42 patients. The application of visual ultrasound technology identifies and marks the lesion site. Under ultrasound guidance, a posterior approach is used to puncture into the joint capsule space between the humeral head and glenoid labrum. Following successful puncture, drug injection therapy is administered. Shoulder joint pain levels and shoulder joint function were compared between the two groups at baseline, 6 weeks post-treatment, and 12 weeks post-treatment. Blood glucose levels were monitored at baseline, 1 day post-treatment, and 3 days post-treatment. Adverse reactions, including rash, abnormal liver function, gastrointestinal reactions, and dizziness/headache, were observed in this study. Results: After 6 weeks and 12 weeks of treatment, the visual analogue scale (VAS) scores for shoulder pain severity and shoulder function were 3.62 ± 1.03 and 1.03 ± 0.25, respectively, in the combined betamethasone and PRP injection group. In the betamethasone local injection group, these scores were 4.56 ± 1.31 and 1.54 ± 0.32, respectively. Comparisons between the two groups yielded p values of .001 and < .001, indicating statistically significant differences. Constant-Murley Shoulder Function Score (CMS) results for the combined betamethasone and PRP injection group were 50.37 ± 6.23 and 80.72 ± 10.69, respectively. For the betamethasone local injection group, the scores were 46.85 ± 6.11 and 73.54 ± 8.23, respectively. Comparing the two groups, the p-values were .011 and < .001, respectively, indicating statistically significant differences. Comparison of blood glucose levels between the two groups: After 1 day and 3 days of treatment, fasting blood glucose levels in the combined betamethasone and PRP injection group were 5.67 ± 0.14 and 5.69 ± 0.13 mg/dL, respectively, while those in the betamethasone local injection group were 6.29 ± 0.35 and 6.35 ± 0.38 mg/dL, respectively. Compared between the two groups, the p-values were < .001 and < .001, respectively, indicating statistically significant differences. 2-hour postprandial blood glucose levels at 1 day and 3 days post-treatment were 6.85 ± 0.25 and 6.87 ± 0.28 mg/dL in the combined betamethasone and PRP injection group, and 8.34 ± 0.21 and 8.49 ± 0.34 mg/dL in the betamethasone local injection group. Comparisons between the two groups yielded p values of < .001 and < .001, respectively, indicating statistically significant differences. The incidence of adverse reactions in the combined betamethasone and PRP injection group was 11.90%, including 1 case of rash, 1 case of abnormal liver function, 2 cases of gastrointestinal reactions, and 1 case of dizziness and headache. The adverse reaction incidence rate in the betamethasone local injection group was 21.43%, including 2 cases of rash, 2 cases of abnormal liver function, 3 cases of gastrointestinal reactions, and 2 cases of dizziness and headache. Comparing the two groups, p > .05, indicating no statistically significant difference. Conclusions: Compared with the betamethasone local injection group, the combined betamethasone and PRP injection group demonstrated lower VAS scores and higher CMS scores at 6 and 12 weeks post-treatment. Additionally, fasting blood glucose and 2-hour postprandial blood glucose levels were lower at 1 and 3 days post-treatment. There was no difference in the incidence of adverse reactions between the two groups. Ultrasound-guided injection of betamethasone combined with PRP demonstrates effective treatment for frozen shoulder and warrants further clinical application.
Chronic obstructive pulmonary disease (COPD), the third leading cause of death globally, is characterized by persistent airflow limitation. In China, the prevalence among individuals aged 40 and above reaches 13.7%, with a noticeable trend toward younger groups. However, inadequate screening rates at the primary healthcare level and delayed diagnosis pose significant challenges. Researches have indicated that standardized screening questionnaires combined with AI-assisted lung function interpretation technology can enhance the efficiency of early diagnosis. Treatment requires individualized medication combined with non-pharmacological interventions (health education, telemedicine, and smart inhalation devices) to enhance the adherence and the symptom control. In terms of management, the community-based primary healthcare system, home oxygen therapy, and multidisciplinary pulmonary rehabilitation programs can shorten the hospitalization duration during acute exacerbations and then improve outcomes. The findings indicate that an integrated strategy combining early screening, tiered diagnosis and treatment, digital management and community-family collaboration is key to reducing disability and mortality rates from COPD. In the future, it is needed to focus on strengthening primary healthcare capabilities and implementing evidence-based precision interventions to drive a shift from “passive treatment” to “proactive healthcare management,” thereby alleviating socioeconomic burdens.
Objective: MRI and CT techniques were used to examine carotid artery stenosis and carotid ulcer plaque in patients with carotid artery stenosis, and the diagnostic value of MRI and CT was explored through comparative studies. Methods: MRI examinations were performed by using high-resolution Magnetic Resonance Imaging 3D Black Blood Technology, and CT examinations were performed by means of Computed Tomography Angiography. The cases consisted of 68 patients with carotid artery stenosis accompanied by carotid ulcerative plaques admitted to the Department of Neurology of a tertiary hospital from January 2020 to December 2020, who underwent quantitative measurements with both high-resolution magnetic resonance imaging 3D black blood technology (cervical part) and computed tomography angiography, and digital subtraction angiography (DSA) was taken up as the gold standard to compare and analyze the two tests for the diagnostic value of carotid artery stenosis and carotid ulcerative plaque. Results: In our group of 68 patients with carotid artery stenosis accompanied by carotid ulcerative plaques, there were 10 unilateral lesions and 58 bilateral lesions, with a total of 126 diseased carotid arteries; 3 diseased vessels with poor image quality were excluded, and 123 diseased carotid arteries were included in the comparative study. The two methods were compared in the measurement of lumen area, wall area and external area of the wall of the diseased carotid artery (p = .273, p = .240, p = .941), the difference was not statistically significant; in the comparison of luminal stenosis rate, t = 0.905, p > .05, the difference was not statistically significant; Pearson correlation analysis showed that the two methods were positively correlated with the luminal stenosis rate measured by DSA (r = 0.961, 0.952, p < .001). Using DSA as the gold standard, the sensitivity, specificity, and Youden’s J statistic of the two methods for stenosis > 70% were 93.88%, 100.00% and 0.939 for the high-resolution magnetic resonance imaging 3D black blood technology, and 91.83%, 93.24% and 0.851 for the computed tomography angiography technology, respectively; in terms of the diagnosis of carotid ulcerative plaques, the high-resolution magnetic resonance imaging 3D black blood technology detected 38 cases, computed tomography angiography detected 35 cases, DSA detected 33 cases, the sensitivity, specificity and Youden’s J statistic of the two methods for the diagnosis of carotid ulcerative plaques were compared, the high-resolution magnetic resonance imaging 3D black blood technology was 100.00%, 91.44%, 0.914, and computed tomography angiography was 78.79%, 90.00% and 0.688. Conclusions: There was no difference between high-resolution magnetic resonance imaging 3D black blood technology and computed tomography angiography in the measurement of lumen area, wall area and external area of the wall of the diseased carotid artery, and there was no difference in luminal stenosis rate, and there was a higher diagnostic value in luminal stenosis rate and the diagnosis of carotid ulcerative plaques, but the diagnostic value of carotid ulcerative plaques was higher with high-resolution magnetic resonance imaging 3D black blood technology.
This paper systematically summarizes the latest research progress of quorum sensing system and the formation and regulatory mechanism of bacterial biofilms. The role of quorum sensing system in various stages of biofilm formation is described, including initial adhesion, microcolony formation and biofilm maturation. In addition, the molecular mechanism of quorum sensing system to regulate the formation of biofilms and the biofilm prevention and control strategies for quorum sensing system are also discussed. Finally, the future development direction of quorum sensing system and bacterial biofilm research is prospected.
Objective: Kawasaki disease (KD) is the leading cause of acquired heart disease in children. Aspirin is widely used in KD management, but its use in glucose-6-phosphate dehydrogenase (G6PD) deficiency is challenging due to the risk of hemolysis. This report discusses the management of KD in a child with G6PD deficiency. Case presentation: A 2-year-7-month-old girl presented with fever, jaundice, and rash. She developed classic KD symptoms, including conjunctival injection, strawberry tongue, and limb edema, with laboratory findings of elevated inflammatory markers, anemia, and thrombocytosis. Diagnosed with KD, she was treated with IVIG, dipyridamole, and low-dose aspirin to mitigate hemolysis risk. The patient recovered without complications, and follow-up revealed no coronary artery abnormalities. Conclusions: Low-dose aspirin combined with other antiplatelet agents, such as dipyridamole, may have been safely used in this patient with G6PD deficiency. Individualized treatment strategies are essential, and further research is needed to optimize aspirin use in this population.
Lung cancer is one of the most common malignancies with the highest morbidity and mortality in the world, and the existing treatment methods often face challenges such as toxic side effects and drug resistance. Human umbilical cord mesenchymal stem cells (hUC-MSCs) have become a promising new strategy in cancer treatment due to their unique biological characteristics (e.g., self-renewal, multi-differentiation and immune regulation). This paper reviews the mechanism of hUC-MSCs in regulating the proliferation, apoptosis, invasion and metastasis of lung cancer cells and tumor microenvironment, and discusses the dual effect of HUC-MSCs in promoting or inhibiting cancer. In addition, this paper also discusses the engineering transformation strategy of hUC-MSCs as gene and drug carriers, which provides a new research idea and theoretical basis for the development of hUC-MSC-based targeted therapy for lung cancer.
Bacterial biofilms (BFs) are widely present in nature, and more than 99% of bacteria can form BF, which is an important factor leading to persistent infection of refractory wound and repeated infection. The formation of BF is a dynamic cyclic process involving various physical, chemical and biological processes, mainly including bacterial attachment, BF formation and maturation, and bacterial diffusion. The bacteria in bacterial biofilms are more resistant to antibiotics and disinfectants, and more resilient to environmental changes, which presents many challenges in treatment. This article reviews the basic characteristics, resistance mechanisms and treatment strategies of BF. At present, there are many studies on the treatment of BF, which need to be selected according to the specific situation and pathophysiological process of wound infection, and can be used as a single method or in combination. This article introduces some treatment methods to provide a reference for the clinical prevention and treatment of BF.
Objective: To explore the value of cyclosporin eye drops in treating dry eye after cataract surgery.Methods: A total of 150 patients with dry eye after cataract surgery were randomly divided into group A (n = 50), group B (n = 50), and group C (n = 50). Artificial tears combined with cyclosporin eye drops were used in group A, artificial tears were used in group B, and no dry eye medication was used in group C. The clinical efficacy, ocular surface function and tear inflammatory factor level before and after surgery were compared between the groups.Results: The total effective rate of group A was 96.00%, which was significantly higher than that of group B and group C (p < .05); three months after surgery, the levels of corneal fluorescein staining score (FL score), tear meniscus height (TMH) and tear inflammatory factors [interleukin 6 (IL-6), interleukin 8 (IL-8), tumor necrosis factor (TNF-α)] in group A were lower than those in group B, and those indicators in group B were lower than those in group C, and the difference between the two groups was statistically significant (p < .05); three months after surgery, Schirmer test (SIT) and break-up time (BUT) in group A were higher than those in group B, and those indicators in group B were higher than those in group C, and the difference between the two groups was statistically significant (p < .05).Conclusions: The effect of cyclosporin eye drops in treating dry eye after cataract surgery is satisfactory, significantly improving the ocular surface function and reducing the level of tear inflammatory factors, which is worthy of promotion.
Objective: Kawasaki disease (KD) is an acute, self-limiting vasculitis and the most common cause of acquired heart disease in children under 5 years old. Despite over 50 years of research, the etiology and long-term prognosis of KD remain unclear.Case presentation: A 2-year-7-month-old boy presented with all the typical KD symptoms, including conjunctival injection, cracked lips, strawberry tongue, and membranous desquamation of the fingers and toes, but without fever. The patient was admitted with a 9-day history of peeling skin on his fingers, and no history of illness or fever in the past two weeks. Laboratory tests revealed elevated platelet count. An echocardiogram showed normal coronary arteries. The patient was diagnosed with KD and treated with low-dose aspirin and dipyridamole. He was discharged on the third day and showed complete symptom resolution and normal coronary arteries at follow-up.Conclusions: This case report describes an instance of afebrile KD, emphasizing the need for clinical vigilance and comprehensive assessment for diagnosis and treatment. Afebrile KD poses a diagnostic challenge as fever is a major diagnostic criterion. However, clinicians should consider afebrile KD when other clinical features and laboratory results suggest KD, and initiate appropriate treatment to prevent severe complications like coronary artery lesions. This case underscores the importance of early diagnosis, timely intervention, and multidisciplinary team collaboration for effective management of KD.
Objective: To investigate the expressions of AEG-1, NKD-1 and β-catenin in gastric cancer (GC), and analyze their relationship with clinicopathological features and prognosis and the correlation among the three proteins.Methods: Fifty GC tissues and 50 adjacent normal tissues of patients who underwent radical gastrectomy in the Third Affiliated Hospital of Inner Mongolia Medical University during December 2015 to June 2017 were collected. The expressions of AEG-1, NKD-1 and β-catenin were detected by immunohistochemical SP method and qRT-PCR. The relationship between positive expression and clinical features and survival time of patients was analyzed, and the correlation between the three was analyzed.Results: The positive expression rates of AEG-1 and β-catenin in gastric cancer were 74% (37/50), 60% (30/50), respectively, which was significantly higher than that of paracancer tissue (18% [9/50] and 26% [13/50]). The positive expression rate of NKD1 in gastric cancer tissues was 20% (10/50), which was significantly lower than that in adjacent tissues [88% (44/50)]; and the differences were statistically significant (p < . 05). AEG-1 mRNA expression level (1.0148±0.0019) and β-catenin mRNA expression level (1.0000±0.0005) in gastric cancer tissues were significantly higher than that of AEG-1 mRNA expression level (1.0002±0.0036) and β-catenin expression level in adjacent tissues mRMA expression level (0.9984±0.0012), and the differences were statistically significant (p < .05). The expression level of NKD1 mRNA in gastric cancer tissues (1.0008±0.0073) was significantly lower than that in adjacent tissues (1.0291±0.0041), and the differences were statistically significant (p < .05). The positive expression of AEG-1, NKD1 and β-catenin in gastric cancer tissues was not related to age, sex or tumor size (p > .05), but was related to differentiation degree, TNM stage and lymph node metastasis (p < .05). In gastric cancer, there was a positive correlation between AEG-1 and β-catenin protein expression (r = .678, p < .001), and a negative correlation between AEG-1 and NKD1 protein expression (r = -.323, p = .012). β-catenin expression was negatively correlated with NKD1 expression (r = -.347, p = .007). The survival time of patients with positive expression of AEG-1 and β-catenin was significantly shortened compared with those with negative expression (p < .05), while the survival time of patients with positive expression of NKD1 was longer than that of patients with negative expression of NKD1 (p < .05).Conclusion: The abnormal expression of AEG-1, NKD-1 and β-catenin is closely related with the occurrence, development, invasion, metastasis and prognosis of gastric cancer, which provide a therapeutic target and may become markers for prognosis evaluation.
Objective: To investigate the effect of liraglutide on diabetic nephropathy in rats and its regulatory mechanism. Methods: The diabetic nephropathy rat model was constructed with high-glucose-high-fat diet in combination with STZ, and was randomly divided into normal saline group and liraglutide group. The rats in liraglutide group were given sc 200 μg/kg of liraglutide, and the rats in normal saline group were given sc 20 mg/kg of normal saline twice a day for 4 weeks. The normal control group was not treated with any treatment. The biochemical indexes such as rat body weight, 24-hour urine total protein quantification (UTP), fasting blood glucose (FPG), triglyceride (TG), cholesterol (TC), blood urea nitrogen (BUN) and serum creatinine (Scr) were measured. HE staining, Masson staining and PAS staining were used to observe the pathologically morphological changes in renal tissues. Western-blot was used to detect the expression of NLRP3 inflammasome-related protein in renal tissues. Elisa was used to measure the serum levels of interleukin-18 (IL-18) and IL-1β. SPSS 26.0 statistical software and Graph Prism 9.0 software were used for analysis and mapping. The t-test was used for the comparison of measurement data between two groups, one-way ANOVA was used for the comparison among multiple groups, and Tukey’s test was used for the comparison in the same group. Results: Compared with the normal saline group, FBG, UTP, BUN, Scr, TC and TG in the liraglutide group were significantly decreased (p < .01), the glomerular basement membrane was slightly thickened, with the tubular lumen slightly dilated and the lesion damage alleviated; the expression levels of NLRP3, ASC and caspase-1 inflammasome-related proteins were decreased (p < .01), and the levels of IL-18 and IL-1β were decreased (p < .01).Conclusion: Liraglutide can inhibit the activation of NLRP3 inflammasome mediated by oxidative stress in renal tissues through ROS-NLRP3 inflammasome pathway, thereby inhibiting the inflammation, and finally playing an anti-diabetic nephropathy renal injury role.
Objective: To explore the effect and mechanism of donepezil hydrochloride on Alzheimer’s disease (AD).Methods: Thirty-six 3-month-old SD rats were selected as the research subjects and randomly divided into a normal control (NC) group and a model group. The model group was given continuous intraperitoneal injection of D-galactose solution (120 mg/kg/d) combined with aluminum trichloride (10 mg/kg/d) by gavage for 60 days. Morris water maze test was conducted to test the learning and memory abilities of the rats, and AD rats were selected. After modeling, AD rats were divided into a normal saline (NS) group and a drug treatment (DT) group. The DT group was given donepezil hydrochloride (1.0 mg/kg) by gavage intervention, and the NC group and the NS group were given equal volumes of physiological saline by gavage. After 4 weeks of intervention, Morris water maze test was conducted to detect the escape latency, the number of platform crossings and residence time in the target quadrant, the rats were euthanized, with serum and hippocampal tissues collected, and hippocampal tissue homogenate (10%) was prepared by using NS. Enzyme linked immunosorbent assay (ELISA) was used to detect the inflammatory and oxidative stress indicators in rat hippocampal tissues and serum, and hematoxylin eosin (HE) staining was used to observe pathological damage in rat hippocampal tissues.Results: Compared with the NC group, the NS group showed a significant increase in escape latency (p < .05), a significant decrease in the number of platform crossings and residence time in the target quadrant (p < .05), and a significant decrease in the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in serum and hippocampal tissues (p < .05). The content of malondialdehyde (MDA) was significantly increased (p < .05), and the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were significantly increased (p < .05). Compared with the NS group, the DT group can significantly reduce the escape latency (p < .05), increase the number of platform crossings and residence time in the target quadrant (p < .05), significantly increase the activities of SOD and GSH-Px in serum and hippocampal tissues and reduce the content of MDA (p < .05) and the levels of IL-6 and TNF-α (p < .05). After intervention with donepezil hydrochloride, the number of neurons in the hippocampus were significantly increased.Conclusions: Donepezil hydrochloride can improve the learning and memory abilities of rats, reduce the levels of oxidative stress and inflammation in the brain and serum, and improve pathological damage in the hippocampus.
Cell therapy represents an important area of biotechnology, with the potential to treat and even cure a variety of diseases that cannot be cured by traditional therapies. Cell therapy is currently a widely studied treatment in both preclinical and clinical settings, and many cell therapy products are undergoing clinical trials. This article reviews the application of cell therapy in a variety of diseases and the policy of stem cell therapy in China.
Objective: To explore the combined effects of multisensory intervention and amplitude integrated electroencephalogram monitoring on the maturation and evaluation of brain and neural development in premature infants of different gestational ages. Methods: The controlled trial was carried out in 62 premature infants from January to February of 2023 in Genertec AMHT - Baogang Hospital. The premature infants were divided into two groups according to the gestational age: 32-33+6W (Group A) and 34-36+6W (Group B). By use of random number table method, each group was subdivided into the control group and the experimental group. The control group was monitored with aEEG within 1 day and the following 7 days after birth. The experimental group was monitored with aEEG within 1 day and the following 7 days after multisensory intervention (MS) to observe the change of aEEG parameters, in order to explore the effect of MS intervention on brain development maturity. The Neonatal Behavioral Neurological Assessment (NBNA) score was performed at 40 weeks of corrected gestational age in both groups. Results: The amplitude voltage, the total aEEG score and the sleep-wake cycle score in the experimental group were higher than those in the control group (p<.05). The total NBNA score in the experimental group was higher than that in the control group. Conclusions: The multi-sensory intervention is a simple and feasible method of development support nursing, it can improve the total NBNA score of premature infants, which can promote the brain development in premature infants and improve their neurodevelopmental behavior.
Periodontal disease is a chronic infectious disease, which is common and frequent disease in pregnant women. It is an infectious disease caused by a variety of microorganisms, and the physiological changes in pregnant women after pregnancy can promote the occurrence and development of periodontal disease. Women no less than 35 years old are at an increased risk of maternal and fetal complications in pregnancy, older pregnant women with periodontal disease are prone to preterm birth, fetal growth retardation, premature rupture of membranes, and the incidence of neonatal low birth weight is significantly higher than that in older women with healthy oral health,i.e., these risks are increased with age. C-reactive protein (CRP) is an acute-phase protein produced by liver organs, which is produced by hepatocytes under the promotion of inflammatory factors, and serves as the most direct and sensitive marker of inflammatory response. Studies have shown that basic periodontal treatment relieve periodontal tissue inflammation in pregnant women with periodontitis, while significantly reducing their serum CRP concentration, thereby decreasing the occurrence of adverse pregnancy outcomes. The objective of this study is to investigate the effect of basic periodontal treatment on CRP in elderly pregnant women with periodontal disease.
Objective: To explore the application effect of improved Beck oral score in oral care of burn patients with mechanical ventilation, to provide practical basis for oral care of such patients.Methods: A total of 42 patients with tracheotomy and mechanical ventilation in the Department of Burn Surgery of Baogang Hospital in Inner Mongolia from January 2021 to December 2022 were selected as the study objects, and the patients were randomly divided into observation group and control group, with 21 cases in each group. The control group was given routine oral care, and the observation group was given oral care according to improved Beck oral score. The following were compared between the two groups: Age, total burn area, third-degree burn area, acute physiological and chronic health assessment scores, as well as improved Beck oral scores; the incidence of oral odor, plaque index, mouth ulcer and ventilator-associated pneumonia (VAP) after 7 days; the detection of microorganism in oral secretions.Results: After 7 days, the oral condition of patients in observation group was effectively improved, and the oral comfort level was significantly improved. The incidence of oral odor (2.57±1.59), dental plaque index (2.62±1.47), oral ulcer evaluation (2.24±1.09), VAP incidence (9.52%) and improved Beck oral score (8.09±1.92) in observation group were all lower than those in control group, which was (3.95±1.82), (3.57±1.21), (3.14±1.24), (38.09%), and (9.90±2.21) respectively. The difference was statistically significant (p < .05). The oral normal flora in observation group (71.43%) was higher than that in control group (28.57%), and the difference was statistically significant (p < .05). The oral gram-positive bacteria (19.05%) and Gram-negative bacteria (23.81%) in observation group were lower than those in control group, which was 52.38% and 57.14% respectively, and the difference was statistically significant (p < .05).Conclusions: The application of the improved Beck oral assessment method in dynamic oral care can effectively reduce the content of oral pathogens, lower the incidence of pulmonary infection, and improve the quality of life of patients.
Aim: To provide suggestions for clinical diagnosis, treatment and eugenics through the retrospective analysis of a case of neonatal machete syndrome.Methods: The clinical data of a newborn with machete syndrome admitted to the pediatrics department of Baogang Hospital of Inner Mongolia were analyzed, and suggestions of eugenics were provided based on the literatures.Results: The child, male, natural conception, G2P2, gestational age 38+4 weeks, was born by cesarean section (at am 09:24 on November 13th, 2021). He was hospitalized in our department for 9 days and given NCPAP positive pressure ventilation to give oxygen and anti-infection symptomatic treatment. The dyspnea of the child was not significantly alleviated, and the heart murmurs became increasingly obvious. The child was transferred to the neonatology Department of the Seventh Medical Center of the PLA General Hospital for further treatment on 9 days after birth. After admission, piperacillin and tazobactam were treated with anti-infection, high-frequency oscillation mode of invasive ventilator, limited fluid volume and other symptomatic treatments. Fiberbronchoscopy showed atelectasis of right lung and tracheomalacia of left lung. Echocardiography showed partial anomalous pulmonary venous drainage, atrial septal defect (secondary foramina), inferior vena cava dilatation, pulmonary hypertension, initial coronary artery dilatation, and patent ductus arteriosus. CT 3D imaging of pulmonary veins showed: Congenital heart disease: partial anomalous pulmonary venous drainage (subcardial), consideration of "machete syndrome," atrial septal defect, consideration of pulmonary hypertension, right pulmonary artery stenosis, right lower lung receiving abdominal aorta blood supply, right lung tissue dysplasia, and widening of inferior vena cava pulmonary veins. Therefore, the comprehensive diagnosis was "machete syndrome." Considering the high surgical risk of the child, conservative symptomatic treatment was recommended, and the family requested discharge after 22 days of treatment. The patient died at home at 3 months follow-up after discharge.Conclusions: Machete syndrome is a rare congenital property of abnormal partial or complete pulmonary venous drainage from the right or left lung to the inferior vena cava. With an incidence of approximately 2 in 100,000 live births, the syndrome is commonly associated with right lung dysplasia, pulmonary sequestration, persistent left superior vena cava, and right tilt of the heart. In this case, the child had these syndromes after birth, since the primary hospital did not recognize the disease, the child was clearly diagnosed in the higher hospital. Children with machete syndrome can be treated with surgery in the early neonatal period, but the indication of surgical treatment is still controversial, and the need for surgery is evaluated according to the severity of the patient's symptoms and pulmonary circulation blood flow.
Objective: To explore the effect of ADOPT (Attitude, Definition, Open mind, Planning, Try it out) nursing intervention mode on the living habit compliance, self-monitoring compliance and quality of life of kidney transplant patients in 1-3 years after surgery.Methods: From December 2020 to August 2021, 48 patients in 1-3 years after kidney transplantation who met the inclusion and exclusion criteria and were regularly followed up in the Kidney Transplantation Clinic of the Department of Urology Surgery in Baogang Hospital were selected as the research subjects, and 48 kidney transplant patients were divided into the intervention group and the control group by simple random sampling. The control group was given routine nursing care in the Kidney Transplantation Clinic of the Department of Urology Surgery, and the intervention group was given nursing care measuresformulated on the basis of ADOPT nursing intervention mode. The compliance and quality of life of the two groups were compared with the Kidney Transplant Patient Compliance Scale and the Kidney Transplant Patient Quality of Life Related Rating Scale in 1-3 years after surgery.Results: After 2 months and 4 months of intervention, the scores of living habit compliance and self-monitoring compliance in the intervention group were significantly higher than those in the control group (p < .001), and the scores of quality of life in the intervention group and the total score of quality of life were better than those in the control group, and the difference was statistically significant (p < .001).Conclusions: The implementation of the ADOPT nursing intervention mode for kidney transplant patients in 1-3 years after surgery can improve their compliance level and enhance the quality of life, which is worthy of reference.
Inflammation is generally considered as a pathological process, and the occurrence of multi-organ inflammatory diseases is usually accompanied by an inflammatory response. Persistent inflammation can eventually lead to organ dysfunction. In recent years, the study of mesenchymal stem cell-derived exosomes has found its unique anti-inflammatory effect, which provides a new idea for the treatment of multi-organ inflammatory diseases. This article reviews the effect of mesenchymal stem cell exosomes on multi-organ inflammatory diseases.
