Background The industrial city of Zhezkazgan is one of the most important cities in the industrial sector and the most polluted city in the Republic of Kazakhstan. There is placed Kazakhstan's largest copper smelter. The entire technological process (extraction, crushing, grinding, purification, and smelting of pure ingots) of the production of the copper smelter releases into the environment mainly various kinds of solid particles, sulfur oxides (SOx), and various carcinogenic elements. Emissions from the industrial facilities extend to a significant area around the city, combined with other sources of environmental pollution (motor transport, thermal power plant, individual heating systems, and others). Objective This study assessed the health status of residents of villages near Zhezkazgan by screening, quality of life studies, and official medical statistics. Methods This study assessed the health status and quality of life of residents near Zhezkazgan city. The cohort included residents from Talap village (main group) and Malshybai village (comparison group) from the Ulytau district in the Karaganda region. The sampling for the health check and quality of life survey covered 260 adult residents of Talap village and 146 adult residents of Malshybai village. Univariate analysis was used to calculate the odds ratio (OR) with a 95% confidence interval (95% CI). Results In the city district of Zhezkazgan, the overall mortality rate and mortality from diseases of the circulatory system, neoplasms, and respiratory diseases were much higher than in the Karaganda region and the Republic of Kazakhstan from 2015–2020. Residents of the Talap settlement had higher rates of coronary heart disease (CHD) (OR 1.30; 95% CI: 0.70–2.39; and p < 0.05), arterial hypertension (AH) (OR 1.84; 95% CI: 1.11–3.03; and p < 0.05), decreased hemoglobin (OR 1.89; 95% CI: 1.17–3.07; and p < 0.05), and endocrine diseases (diabetes mellitus, obesity, and thyrotoxicosis) (OR 1.76; 95% CI: 1.12–2.79; and p < 0.05) at registration than residents of the Malshybai settlement. Residents of both settlements expressed dissatisfaction with the quality of drinking water and the presence of the area where launch vehicles fell. Conclusion Indicators of pollution in the city, statistics of official mortality, and differences in morbidity indicated the negative impact of hazardous emissions from industrial facilities of the copper smelter on public health.
Objective. To investigate the role of C-reactive protein (CRP) in the prognosis of prostate cancer (PCa). Methods. The studies related to C-reactive protein and prostate cancer were searched by computer, including PubMed and Web of Science. The retrieval time was from the establishment of the database to August 2022. QUADAS score was employed to assess the studies’ quality, funnel plot was employed to analyze the bias of the included studies, and RevMan and STATA statistical software programs were used to draw forest maps to represent the analysis results. Results. In the initial examination, 432 articles were obtained. After removing the duplicate articles, reading the abstract and theme, and then reading the full text, 12 articles finally met the inclusion criteria. The results revealed that serum C-reactive protein (CRP) levels were associated with overall survival (OS) in patients with PCa (OR = 1.47 [1.19, 1.82], P<0.05), and patients with high CRP levels had an increased risk of developing prostate cancer (HR = 0.26, 95% CI: 0.23, 0.29). However, there was no obvious difference in circulating CRP levels between patients with prostate cancer and healthy controls (P>0.05). Conclusions. CRP levels are associated with PCa patients′ OS. High CRP levels have an elevated incidence of PCa, but there was no obvious distinction in circulating CRP levels between patients with prostate cancer and healthy controls. Therefore, C-reactive protein has certain reference value for judging the prognosis of prostate cancer.
