【Objective】 To observe the analgesic effect of flurbiprofen axetil assisted intravenous patient-controlled analgesia（PCA） on patients undergoing orthopedic surgery. 【Methods】 Two hundred orthopedic surgery patients admitted to our hospital from February 2021 to February 2022 were selected as the research objects. The patients were divided into an observation group and a control group by lottery, with 100 cases in each group. The control group received conventional PCA after surgery. The observation group was treated with flurbiprofen axetil assisted by PCA for analgesia. The preoperative and postoperative HR, MAP and other physical indicators were compared between the two groups, and the pain conditions at different time points such as 1, 3, 5, and 7 hours after the operation were compared between the two groups, the number of PCA compressions within 72 hours after surgery,the time of stopping, the time of the first off-bed activity, hospital stay, NE, Cor, AT-Ⅱ, the occurrence of adverse events and the quality of life after surgery were compared between the two groups. 【Results】 The preoperative HR and MAP of the two groups of patients were similar（P＞0.05）; postoperatively, the HR and MAP of the observation group, the VAS score at 1, 3, 5, and 7 hours after the operation, the number of PCA compressions within 72 hours, the stop time, the time of the first off-bed activity, hospital stay, NE, Cor, and AT-II were lower than those of the control group, the incidence of adverse events of the observation group [7.00%（7/100）] was lower than that of the control group [19.00%（19/100）], and the scores of SF-36 were higher than those of the control group（P＜0.05）. 【Conclusion】 Flurbiprofen axetil assisted PCA can significantly enhance the postoperative analgesic effect of patients undergoing orthopaedic surgery, and has positive significance in reducing postoperative stress reaction, promoting physical recovery, reducing the risk of adverse events and improving the quality of life.
Mitosis is the basis of eukaryotic cell reproduction, and the mitotic orientation of cells is precisely regulated.Misorientation of mitosis often leads to aberrant development and tumorigenesis. While previous studies have focused on the exploration of molecular mechanisms, in recent years it has been found that biomechanics plays an increasingly important role in mitotic orientation. In this paper, we focus on the biomechanical progress of mitotic orientation and review both the mechanical regulatory mechanisms and the molecular structure.
Nerve growth factor（NGF） is an important trophic factor affecting nerves. It is released by target tissues to ensure functional contact between target and its innervation. NGF/TrkA signaling is a complex regulator of sensory afferents in response to injury and inflammation, and has been implicated in various pathologies such as pain, interstitial cystitis or bronchial asthma. At present, NGF/TrkA pathway is involved in the urination pathway to regulate neuronal function and participate in a variety of bladder lesions, which may represent a feasible target for the treatment of bladder dysfunction. This review aims to summarize the current experimental and clinical evidence on the role of NGF/TrkA in the bladder, so as to explore the role of NGF/TrkA signaling in bladder dysfunction diseases.
目的 探讨丁苯酞联合多奈哌齐对卒中后血管性痴呆(VD)患者认知功能、痴呆程度、血液流变学、脑微循环、血清因子的影响.方法 选取南阳市第二人民医院2020年2月至2021年9月就诊的卒中后VD患者94例,根据采取的药物治疗方案不同,分为多奈哌齐组(n=47)和丁苯酞+多奈哌齐组(n=47).对比两组治疗效果、认知功能(MMSE评分)、痴呆程度(HDS评分)、生活能力(ADL评分)、血液流变学相关指标[血浆黏度(PV)、红细胞压积(HT)、纤维蛋白原(FIB)、全血黏度(WBV)]、脑微循环指标[特性阻抗(Zc)、临界压力(CP)、脉搏速度(Wv)、动态阻力(Dr)、外周阻力(Rc)]及神经功能相关因子[神经生长因子(NGF)、低氧诱导因子-1α(HIF-1α)、雌激素(E2)、神经营养因子(BDNF)].结果 丁苯酞+多奈哌齐组总有效率(93.62％)高于多奈哌齐组(78.72％)(P＜0.05);治疗3个月后,丁苯酞+多奈哌齐组MMSE、HDS评分高于多奈哌齐组,ADL评分低于多奈哌齐组(P＜0.05);治疗3个月后,丁苯酞+多奈哌齐组PV、HT、FIB、WBV低于多奈哌齐组(P＜0.05);治疗3个月后,丁苯酞+多奈哌齐组CP高于多奈哌齐组,Zc、Wv、Dr、Rc低于多奈哌齐组(P＜0.05);治疗3个月后,丁苯酞+多奈哌齐组E2、NGF、BDNF水平高于多奈哌齐组,HIF-1α水平低于多奈哌齐组(P＜0.05).结论 丁苯酞联合多奈哌齐对卒中后VD患者的疗效显著,可提高患者的认知功能,改善患者的痴呆程度、脑血流、神经功能,调节微循环,从而提高患者的日常生活能.
【Objective】 To investigate the expression of inflammatory factors in patients with dentition defect and its relationship with the effect of oral implant repair, so as to provide guidance for the follow-up diagnosis and treatment. 【Methods】 A total of 117 patients with dentition defect who received oral implant repair treatment in the hospital from February 2019 to December 2021 were enrolled in this study by chance sampling. All patients were followed up for 1 month after the treatment, and the effects of oral implant repair were observed when the patients were followed up for 1 month. They were divided into good repair group and poor repair group. The general data and laboratory examination results of patients were investigated, and the inflammatory factors including C-reactive protein（CRP）, interleukin-6（IL-6）, human interferon γ（INF-γ） and tumor necrosis factor-α（TNF-α） were detected. The relationship between inflammatory factors and the effect of oral implant repair in patients with dentition defect was analyzed. 【Results】 Among 110 patients with dentition defect who received oral implant repair, 18 patients had poor oral implant repair, accounting for 16.36%. The levels of CRP, INF-γ, IL-6 and TNF-α in the poor repair group were higher than those in the good repair group, with a statistical significant difference（P＜0.05）. By point binary correlation test, the inflammatory factors CRP, INF-γ,IL-6 and TNF-α were positively correlated with the effect of oral implant repair in patients with dentition defect（r＞0, P＜0.05）.According to the bivariate Pearson correlation coefficient test, there was a positive correlation between CRP and TNF-α, and between IL-6 and TNF-α（r＞0, P＜0.05）. 【Conclusion】 The expression of inflammatory factors in patients with dentition defect is closely related to the effect of oral implant repair. When the level of inflammatory factors increases, it indicates that the effect of oral implant repair is poor. The effect of oral implant repair can be estimated by observing the level of inflammatory factors, and targeted treatment can be implemented in time to improve the therapeutic effect.
【Objective】 To investigate the effect of cervical treatment stent（CEROMOVER ? ） on the outcome of persistent high-risk HPV infection and its impact on vaginal micro-ecology. 【Methods】 The medical records of patients treated in Xiangya Third Hospital of Central South University from June 2021 to June 2022 due to persistent high-risk HPV infection were retrospectively analyzed. According to different treatment methods, 165 patients were divided into stent group and 202 patients in interferon group. 【Results】（1） The complete negative rate of HPV in stent group was 81.82%（135/165）, and the effective rate was 83.64%（138/165）; the complete negative conversion rate of interferon group was 34.16%（69/202）, and the effective rate was 45.05%（91/202）. The complete negative conversion rate and effective rate in the stent group were better than those in the interferon group（P＜0.01）.（2） For patients with persistent high-risk HPV infection, whether in the stent group or the interferon group, there were significant differences in leucorrhea cleanliness, Nugent score, H 2 O 2 , pH value, dominant bacteria, BV and VVC infection rates before and after the HPV turned negative（P＜0.05）.（3） There were significant differences in the vaginal pH value, dominant bacteria,BV and VVC infection rate of patients in the stent group before and after treatment（P＜0.05）. 【Conclusions】 Cervical treatment stent（CEROMOVER ? ） has a significant effect on the negative conversion of persistent high-risk HPV infection and significantly improves the vaginal micro-ecology.
目的 探究神经节苷脂辅助美罗培南治疗新生儿化脓性脑膜炎(PM)的疗效及对患儿症状缓解时间、神经损伤因子、内皮功能的影响.方法 纳入兰考第一医院2018年12至2021年12收治的90例新生儿PM,根据治疗方案不同,分为联合药物组(n=45)、美罗培南组(n=45).美罗培南组给予美罗培南治疗,联合药物组在美罗培南组基础上予以神经节苷脂辅助治疗.比较两组临床疗效、各临床症状缓解时间、住院天数、治疗前后脑脊液蛋白浓度、糖浓度、白细胞数量、神经损伤因子[脑脊液髓鞘碱性蛋白(BMP)、神经特异性烯醇化酶(NSE)、S100钙结合蛋白(S-100β)、β2-微球蛋白(β2-MG)]及血清内皮功能指标[血清一氧化氮(NO)、内皮素(ET)].结果 联合药物组临床总有效率(97.78％)高于美罗培南组(82.22％)(P＜0.05);联合药物组各症状缓解时间及住院天数短于美罗培南组(P＜0.05);治疗后,两组脑脊液蛋白浓度、白细胞数量低于治疗前,糖浓度高于治疗前,且联合药物组蛋白浓度、白细胞数量低于美罗培南组,糖浓度高于美罗培南组(P＜0.05);治疗后,两组脑脊液BMP、NSE、S-100β、β2-MG水平水平低于治疗前,联合药物组脑脊液BMP、NSE、S-100β、β2-MG水平低于美罗培南组(P＜0.05);治疗后,两组血清NO、ET水平低于治疗前,联合药物组血清NO、ET水平低于美罗培南组(P＜0.05);联合药物组神经相关后遗症发生率(6.67％)低于美罗培南组(22.22％)(P＜0.05).结论 神经节苷脂辅助美罗培南治疗新生儿PM的效果确切,可快速缓解各种临床症状,改善脑脊液代谢环境,恢复机体的内皮功能,减轻机体神经功能的损伤,减少神经相关后遗症的发生率,促进病情恢复.
【Objective】 To study the influencing factors of the instability of the single component of the antigen in the kit.【Methods】 Through the methods of antigen buffer ionic strength, pH, different reagent bottle materials and adding blocking agents,the antigen solutions under different conditions were determined at 37℃, the decrease of the luminescence value after acceleration was used to determine the main reason for the instability of the antigen. 【Results】 After adding the high molecular polymer poloxamer 12600 and 14600 to the antigen solution, after the antigen was heated at 37°C for 10 days, the stability was significantly improved, and the decrease of luminescence value decreased from 60% to 8%. 【Conclusion】 The macromolecular polymer has an inhibitory effect on antigen aggregation and maintains the stability of the antigen structure.
【Objective】 To investigate the clinical features and risk factors of patients with plasma cell mastitis. 【Methods】 Through a retrospective case-control study, 93 patients with plasma cell mastitis who were admitted to the Shiyan Renmin Hospital of Hubei University of Medicine from July 2019 to July 2021 were selected as the research group, and 100 patients without breast-related diseases who underwent physical examination in our hospital during the same period were randomly selected as the control group.Relevant information was collected and the clinical manifestations of plasma cell mastitis were summarized. Univariate analysis and multivariate Logistic regression analysis were used to screen the risk factors of plasma cell mastitis. 【Results】 The clinical manifestations of patients with plasma cell mastitis in this group were mainly breast lumps and breast pain. The lesions mostly involved unilateral breast（93.5%）, and the most common initial site was in the nipple areola area（29%）; there were 7 cases（7.5%）accompanied by nipple discharge, 16 cases（17.2%） with inverted nipple, and 5 cases（5.4%） with sinus tract. The results of univariate analysis showed that there were statistically significant differences in breast accumulation during breastfeeding, duration of breastfeeding, history of mental illness（including taking drugs or not）, breast surgery history, previous mastitis history, nipple retraction, and prolactin levels（P＜0.05）; multivariate Logistic regression analysis showed that the history of mastitis, retraction of nipple, breastfeeding duration, and prolactin level were independent risk factors for plasma cell mastitis（P＜0.05）. 【Conclusion】 The clinical manifestations of plasma cell mastitis are various, mainly breast lump and breast pain; breast accumulation during breastfeeding, breastfeeding duration, history of mental illness（including whether or not taking drugs）, breast surgery history, past mastitis history, nipple inversion and prolactin levels are related to the occurrence of plasma cell mastitis. Past history of mastitis,inversion nipple, breastfeeding duration, and prolactin level are independent risk factors for the occurrence of plasma cell mastitis.
【Objective】 Quality control constraint of Hunan Provincial People’s hospital has changed from simple rules and regulations and examination scores to a conscious action criterion. 【Methods】 After the training organized by the whole hospital,all doctors（including residents, trainees, and interns） participated in the examination. According to the four categories of information on the home page, the examination was divided into 5 blank filling questions, 10 single choice questions, and 5 multiple choice questions. The mobile phone scanning test was used. The question bank of each examination was automatically updated, and the examination results were counted with Excel. 【Results】 Before and after the establishment of the quality control system for the first page of medical records, the data quality of the first page of medical records increased from 88.35% to 98.36%, and the number of DRG cases increased by 23.57%. 【Conclusion】 The data indicators in the performance appraisal of three-level public hospitals are the core data that truly reflect the level of three-level diagnosis and treatment of a hospital. Through the comparison before and after training, doctors’ understanding of the importance of filling in the home page is enhanced, and the data quality can be greatly improved.
【Objective】 To analyze the research status and trends in the landscape of hydrogels for bone regeneration based on bibliometric analysis. 【Methods】 The literature on hydrogels for bone regeneration was searched in the Web of Science core database up to December 31, 2021. The bibliometric analysis of the relevant literature data was carried out by using the "Bibliometrix" package of R language. 【Results】 A total of 5502 articles were included and the number of publications and total citations showed a rapid increase in the field of hydrogels for bone regeneration. China and the United States were the most productive and highly-cited countries. The institution with the greatest contribution was Sichuan University, the author contributed the most articles and citations was Tabata Y, while the journal published the most related papers was Biomaterials. The main hotspots were discovered to be associated with components of hydrogels, bone regeneration, and application of hydrogels, while the trend topics were mainly exosomes, three-dimensional（3D） printing, antibacterial, as well as gelatin methacryloyl. 【Conclusion】 The academic influence of hydrogel materials in the field of bone regeneration is gradually increasing, and the future research direction could focus on bone regeneration, exosomes, 3D printing, antibacterial.
【Objective】 To explore the relationship between serum 25-hydroxyvitamin D [25（OH）D] and the risk of thyroid papillary cancer. 【Methods】 A total of 136 cases of papillary thyroid carcinoma（PTC）, 144 cases of benign thyroid nodular disease and 136 cases of normal subjects were selected from the Central Hospital of Xiaogan City from October 2021 to February 2022. The levels of 25（OH）D in blood and 24-hour iodine excretion in urine were detected by liquid chromatography and arseniccerium catalytic spectrophotometry. And input the settlements, gender, age, whether has a history of taking contain vitamin D or iodine drugs, thyroid function, thyroid autoantibodies index levels, liver and kidney function, etc., of all the research object, multiple stepwise Logistic regression analysis was used to explore the serum 25（OH）D levels, urine iodine level’s influence on the risk of developing thyroid papillary carcinoma. 【Results】（1） There was statistically significant difference in gender（P＜0.05）, and no statistically significant difference in age（P＞0.05） among 3 groups.（2） There were statistically significant differences in the levels of FT3, FT4, TSH and TPOAb in 3 groups（P＜0.05）. FT3（3.51 μg/L） in thyroid cancer group was significantly lower than that in benign thyroid nodule and normal thyroid morphology group（P＜0.05）, TSH（3.01 μu/L） and TPOAb（16 u/mL） were significantly higher than that in benign thyroid nodule and normal thyroid morphology group（P＜0.05）.（3） There were statistically significant differences in serum 25（OH）D and urinary iodine level among 3 groups（P＜0.05）. Serum 25（OH）D level in thyroid cancer group was significantly lower than that in benign thyroid nodule group, and the serum 25（OH）D level in benign thyroid nodule group was significantly lower than that in normal thyroid morphology group（P＜0.05）. The level of urinary iodine in thyroid cancer group was significantly higher than that in normal thyroid morphology group and benign thyroid nodule group（P＜0.05）.（4） Multivariate Logistic regression analysis showed that estrogen, low serum 25（OH）D level and high urinary iodine level were the influencing factors of thyroid cancer. 【Conclusion】 Female, low serum 25（OH）D level and high urinary iodine level are risk factors for thyroid cancer.
【Objective】 In order to reduce the malfunction of ECG monitor and ensure the timeliness and safety of using ECG monitor in clinical departments, plan-do-check-action（PDCA） cycle theory was applied to the maintenance and management of hospital ECG monitor. 【Methods】 The ECG monitor in our hospital medical equipment maintenance management system was selected as the research object, and the maintenance management was carried out according to the PDCA cycle theory. The changes of ECG monitors faults before implementation（July 2021 to December 2021） and after implementation（January 2022 to 2022 June）were compared. 【Results】 After formulating and implementing corresponding countermeasures through the PDCA cycle theory,the monthly failure rate of the ECG monitor decreased significantly from 1.68% to 0.61%, the difference was statistically significant（χ2=5.431, P=0.020）. 【Conclusion】 Applying the PCDA cycle theory to the maintenance management of ECG monitor can effectively reduce failure rate, and provides a basis for further extending the theory to the maintenance management of other medical equipment.
【Objective】 To explore the long-term effect of closed surgical eruption initiation combined with orthodontic traction on patients with impacted teeth, and to analyze its influencing factors.【Methods】 A total of 122 patients with impacted teeth who received closed surgical eruption combined with orthodontic traction in Pingdingshan Stomatological Hospital from February 2018 to February 2021 were selected, with a total of 180 impacted teeth. The follow-up was 12 months, and the closed surgical eruption was counted. The correction effect of combined orthodontic traction was divided into a correction effective group（n=154） and a correction ineffective group（n=26）. The clinical data of the two groups were compared, and the influencing factors of the treatment effect were analyzed. 【Results】Among the 180 impacted teeth, 107 were successful, 47 were effective, and 26 were ineffective. Univariate analysis showed that age, labial and palatal orientation, degree of root distortion, traction timing, and intraoperative soft and hard tissue removal range were significantly associated with the effectiveness of closed surgical guide eruption combined with orthodontic traction correction（P＜0.05）; Logistic regression analysis showed that age（＞18 years old, ■=6.700）, labial and palatal orientation（palatal orientation, ■=3.308）, degree of root distortion（＞90°, OR=4.067）, intraoperative bone removal beyond the cementoenamel boundary（ ■=3.057）, and resection of the dental follicle wall ≥1/3（ ■=3.445） were risk factors for ineffectiveness of closed surgical eruption combined with orthodontic traction correction（P＜0.05）; traction timing（the root development did not reach 2/3, ■=0.365） was an effective protective factor for closed surgical eruption combined with orthodontic traction correction（P＜0.05）. Logistic regression model was used to statistically analyze the data set, and the ROC curve was drawn according to the predicted value and the actual value. The AUC was 0.913（95%CI: 0.875–0.951）. When Log（P）＞9.28,the prediction sensitivity was 92.21%, and the specificity was 84.62%. 【Conclusion】 Various factors such as age, lip-palate orientation, root distortion, traction timing, and intraoperative soft and hard tissue removal range can affect the effect of closed surgical eruption combined with orthodontic traction correction of impacted teeth. Targeted corrections are formulated according to the above factors. The program has positive significance for improving the correction effect.
【Objective】To investigate the effect of all-ceramic crown + Cortisomol paste root canal filling in the treatment of patients with cracked pulpitis after root canal therapy. 【Methods】Eighty-six patients with cracked pulpitis（86 teeth） in Pingdingshan Stomatological Hospital（February 2019 to January 2022） were collected and divided into group A（n=43） and group B（n=43） according to different treatment plans. Both groups were treated with Cortisomol paste root canal filling. On this basis, group A was treated with all-ceramic crown restoration group, and B was treated with metal-porcelain crown restoration. The treatment effect, Visual Analogue Scale（VAS） score before and after treatment, masticatory efficiency, bite force, periodontal index [probing depth（PD）, bleeding index（BI）], inflammatory factors of gingival crevicular fluid [tumor necrosis factor-α（TNF-α）, C-reactive protein（CRP）, interleukin-6（IL-6）] levels were compared between the two groups.【Results】 Compared with the total effective rate of group B, which was 81.40%（35/43）, the total effective rate of group A was higher [97.67%（42/43）]（P＜0.05）. Compare with group B, the VAS score of group A was lower after 1 day, 3 days, and 7 days of treatment（P＜0.05）. Compared with group B, the chewing efficiency and bite force of group A were higher after 3 months and 6 months of treatment（P＜0.05）. Compared with group B, BI and PD of group A were lower after 3 months and 6 months of treatment（P＜0.05）. Compared with group B, the levels of TNF-α, CRP and IL-6 in the gingival crevicular fluid of group A were lower after 7 days and 14 days of treatment（P＜0.05）. 【Conclusion】Compared with metal-porcelain crown restoration + Cortisomol paste root canal filling in the treatment of patients with cracked pulpitis, the application of allceramic crown restoration + Cortisomol paste root canal filling can improve the curative effect, reduce pain, improve chewing efficiency and occlusion. It has more advantages in terms of strength, and has less impact on periodontal status and oral inflammation.
【Obejective】 To explore the feasibility, safety, efficacy and prognosis of endoscopic submucosal dissection（ESD）for simultaneous treatment of double primary early and precancerous cancers of the esophagus and stomach. 【Methods】 The clinical data of all patients who received ESD treatment for esophagogastric diseases in Taihe Hospital of Shiyan City from January 1, 2014 to October 1, 2020 were retrospectively analyzed. The patients were followed up for a total of 3 to 24 months. 【Results】 Of the 5 patients, 4 were male and 1 was female. The oldest age is 71, the youngest is 64, and the average age is 67. One patient had a history of hypertension, one patient had a history of diabetes, and none had a history of coronary heart disease. Four patients had a long history of smoking, and three patients had a long history of alcohol consumption. One patient had a family history of esophageal cancer. Location of lesions: all the esophageal lesions were in the middle thoracic section, 2 cases in the gastric antrum, 2cases in the cardia, and 1 case in the gastric body. One patient had circumferential lesions. All the 5 patients had negative horizontal and vertical margins, and all were treated with curative resection. Postoperative pathology: 3 cases of esophageal lesions were squamous cell carcinoma and 2 cases were high-grade intraepithelial neoplasia. Gastric lesions included 1 case of intramucosal adenocarcinoma, 2 cases of high-grade intraepithelial neoplasia, and 2 cases of low-grade intraepithelial neoplasia. There was no recurrence during the follow-up period, and 1 patient died, the cause of death is unknown, and the other 4 patients had no special discomfort after surgery. 【Conclusion】 Simultaneous ESD is safe, feasible and has good short-term prognosis for double primary early cancer of esophagus and stomach and precancerous lesions.
目的 分析基于多层螺旋CT(MSCT)的计算机纹理分析技术对良恶性孤立性肺结节(SPN)的鉴别诊断效能.方法 选取光山县中医院317例SPN患者(2019年10月至2022年1月)作为研究对象,均行MSCT检查和计算机纹理分析,以临床病理结果为诊断的"金标准",SPN患者分为良性组(n=177)、恶性组(n=140),比较两组最大径、CT值、计算机纹理分析特征参数(熵差、相关、熵、均和、熵和、对比度),并分析计算机纹理分析技术联合MSC鉴别良恶性SPN的价值.结果 恶性组纹理特征中熵、熵差、熵和均较良性组高(P＜0.05),而组间结节最大径、平均CT值、均和、相关、对比度比较差异无统计学意义(P＞0.05);以临床病理结果为诊断的"金标准",将病理结果为恶性SPN设为阳性样本,以病理结果为良性SPN设为阴性样本,基于MSCT的计算机纹理分析技术检测的熵差、熵、熵和参数绘制受试者工作特征(ROC)曲线,结果显示,熵差、熵、熵和的截断值分别为0.970、1.571、1.151,熵、熵差、熵和、熵+熵差、熵差+熵和、熵+熵和、熵+熵差+熵和的AUC均＞0.700,灵敏度、特异度均超过60.00％.联合熵+熵差+熵和检测的灵敏度为90.71％,特异度为82.49％.结论 良恶性SPN在熵、熵差、熵和方面存在差异,基于MSCT的计算机纹理分析特征参数,联合熵+熵差+熵和检测的灵敏度和特异度均较高,能帮助临床鉴别良恶性SPN.
【Objective】 Under the influence of the reciprocating COVID-19, the advantages of online education are becoming more obvious. The electronic voice interaction system plays an increasingly important role, which can help students learn professional knowledge and reduce teachers’ teaching pressure. 【Methods】 In this paper, based on STM32 chip, the teaching assistant robot voice interactive control system is designed. Through 32-bit microprocessor core control unit, unique medical engineering, medical imaging and professional databases are built, so that the functions of voice recognition and synthesis can be realized. 【Results】 After the non-specific speech recognition test, the results show that the system can achieve average recognition rate of more than 90% of speech commands. 【Conclusion】 The language generated by the system’s conversion of text is both natural and fluent, and the speech recognition effect is generally better. Through the application of the course teaching of "Medical Imaging Equipment Science" in 2022, good effect has been obtained.
1 病例介绍 患儿,女,1岁5个月,因"间断腹泻、呕吐、发热、血糖低4个月余"来就诊.4个月余前患儿因受凉出现腹泻,糊状便,后出现发热,最高体温39℃,给予退热药可退,伴有呕吐,呕吐物为胃内容物,精神萎靡,饮食欠佳,随后出现昏迷,遂就诊于当地医院,完善血气:pH=6.9;炎症因子:降钙素原(PCT)4.61 ng/mL;血常规:白细胞 10.16(×109/L),血红蛋白 104.00(g/L),血小板608.00(×109/L),首测血糖0.6mmol/L,考虑"低血糖,代谢性酸中毒",给予静点葡萄糖、抗感染、补液对症治疗后上述症状好转,复测血糖恢复正常.
【Objective】 To compare the advantages and disadvantages of three alkaline phosphatase（AP） labeled antiantibody technologies by measuring sensitivity, signal value and clinical relevance. 【Methods】 Alkaline phosphatase and anti-TSH monoclonal antibody were coupled by the same common protein labeling method, and then the kit for quantitative determination of TSH by chemiluminescence method was made. 【Results】 The performance indexes of different reagents obtained by the same labeling process were investigated. The AP of manufacturer S had the best performance and the highest signal value. However, the two AP of manufacturer C have poor performance. 【Conclusion】 According to the performance of the magnetic particle TSH detection kit, the AP process of manufacturer S is a recommended marker for chemiluminescence immunoassay in this study.
