为进一步杜绝学术不端行为、净化学术研究环境,《中国医疗前沿》杂志编辑部已于去年正式用《科技期刊学术不端文献检测系统（AMLC）》。AMLC是经新闻出版总署、科技部、全国科研诚信管理委员会等单位指导,由中国学术期刊（光盘版）电子杂志社与同方网（北京）技术有限公司共同研制开发。该系统以
目的 观察小剂量氨茶碱口服联合呼吸功能训练治疗慢性阻塞性肺疾病(COPD)的疗效.方法 将47例稳定期COPD患者随机分成治疗组及对照组,治疗组给予氨茶碱片口服及呼吸功能训练,对照组仅给予氨茶碱片口服.于治疗前、治疗3个月后对2组患者呼吸困难程度、日常生活活动(ADL)能力、运动耐力及肺功能进行评定.结果 2组患者呼吸困难程度、ADL、运动耐力及肺功能均较治疗前显著改善(均P＜O.05);进一步分析发现,治疗组呼吸功能、ADL及运动耐力的改善幅度较显著,与对照组比较,组间差异均具有统计学意义(P＜0.05).结论 小剂量氨茶碱口服联合呼吸功能训练治疗COPD具有协同疗效,能进一步缓解COPD患者呼吸困难,提高ADL能力及运动耐力,值得临床推广、应用。
Objective To investigate the possible microstructural abnormalities of the cerebral white matter and its changes in adult patients with migraine without aura before and after treatment. Methods Diffusion tensor magnetic resonance imaging(DT-MRI) was carried out in 32 adult patients with migraine without aura and 32 age- and sex- matched healthy controls. Fractional anisotropy(FA) and apparent diffusion coefficient(ADC) were measured at genu, body, and splenium of the corpus callosum(CC) and bilateral frontal white matter, respectively. Results The FA values at the genu, body, and splenium of the CC from patients with migraine without aura before treatment were significantly lower than the control(P<0.01). The FA values at the genu, body, and splenium of the CC after treatment all increased significantly compared with before treatment(P<0.01). However, the FA values at the bilateral frontal white matter were not significant different between the two groups(P>0.05). The ADC values of the above regions were not significantly different between the two groups(P>0.05). There were negative correlations between disease course and the FA values at the genu, body, and splenium of the CC(r=-0.743, -0.742, and -0.363, P=0.000, 0.000, and 0.009, respectively). Negative correlations were also found between headache frequency and FA values at the genu and body of the CC(r=-0.824, and -0.792, P=0.000, and 0.000, respectively). Conclusion There might be an integrity change of neurofibrotic microstructures in the CC in adult patients with migraine without aura, which may be reversible through effective treatment.
Objective To observe the clinical effects of oral taking of Chinese herbal medicine, combined with Wuzhuyu exterl appling of Yongquan acupoint on recurrent oral ulcers(ROU). Methods A total of 128 patients with ROU in the treated group were treated with the combined therapy, and 120 patients in the control group were treated with Western medicine. The clinical efficacy of the two groups was observed. Results On the 6th day after treatment, the reduction of ulcerated and congestive area as well as the degree of pain in the treated group were more significant than those in the control group.The total effective rates were 95.3% and 67.5% respectively, showing significant difference between the two groups. Conclusion Oral taking of Chinese herbal medicine, combined with Wuzhuyu exterl appling of Yongquan acupoint on recurrent oral ulcers had better clinical effects.
Objective To study the patients with polycystic ovary syndrome serum vitamin D concentrations relationship with endocrine disorder.Methods Collected from 78 patients diagnosed with PCOS patients as case group,another 20 cases of healthy women of child-bearing age as controls,calculating body mass index(BMI),serum testosterone(T),estradiol(E2),LH,FSH and the concentration of serum 25-(OH)D3,and OGTT and insulin releasing test,QUICKI index is calculated.Results Cases group 25-(OH)D3 concentration with BMI,T,LH/FSH has certain negative correlation,and QUICKI values were positively correlated.Conclusion Vitamin D deficiency are closely associated with PCOS endocrine disorders,and disorders of vitamin D may also obesity has certain correlation with the patient.
Objective To investigate the clinical features,prognosis and risk factors of patients of acquired immunodeficiency syndrome(AIDS) complicated with cryptococcal meningitis(CM). Methods Totally 27 patients of AIDS with CM who were hospitalized in Changsha Contagious Hospital were enrolled in the study. The clinical data including diagnosis, treatments and prognosis from all the patients were analyzed retrospectively. Results Among the 27 patients entrolled in the study, the positive rate of cerebrospinal fluid india ink smear or Crypotococcus neaformans culture was 100%. The most common symptoms were fever, headache and meningeal irritation sign. The average CD4+lymphocyte count was 40.2/mm3. All the patients showed Concomitant multiple organ infections. The mortality rate was as high as 22%. At the original therapy, the intracranial pressures were remarkably higher in the patients with unfavorable prognosis compared the patients with good prognosis, which was statistically different. Conclusion The results of intracranial pressure test can predict the prognosis. Prompt diagnosis and treatment can decrease death rate of patients. HAART in time of patients reduce relapse rate.
Objective We Explored and analyzed the relationship between current situationand achievements of college students' health behaviors, in order to provide more theory references for improving the health condition and life quality of college students effectively. Methods We analyzed 638 full-time college students of four universities by using muti-stage sampling method. We did a questionnaire investigation on college students' health behaviors and then analyzed it with Likert 5-points scoring method and SPSS software. Results ⑴The scores of college students' health behaviors: 13.7% of them failed, 79.2% of them scored between 60-80 points, while only 7.1% of them scored more than 80 points. The factors such as gender, grade, family address, major and whether the student is the only child in his/her family have no significant effect on their health behaviors(P <0.05). Among the four dimensions of health behaviors, interpersonal support behavior ranks the first, followed by personal life style, study-related behaviors and pressure management behaviors.⑵Among the 620 students who were investigated, the average achievement motivation score is 2.46±8.87, and 64.4% of the 620 students cored more than 0. The factors such as gender, grade, family address, major and whether the student is the only child in his/her family have no significant effect on their health behaviors(P <0.05). The total score of achievement motivation and its dimensions and the total score of health behaviors are positively related. Conclusion The overall level of college students' health behavior is not high. Among the college students health behaviors, interpersonal support behavior is better, while pressure manage behavior needs to be improved. On the whole, the college students have a strong achievement motivation and those students who have a stronger achievement motivation tend to pat more attention to their own health behavior management.
OBJECTIVE: To investigate the rationality of the clinical application of antimicrobial agents in a hospital. METHODS: A cross - sectional study was carried out on the utilization of antimicrobial agents for all the inpatients within a day in our hospital. RESULTS: Among a total of 1503 inpatients investigated,the rate of cross - sectional use of antibiotics was 51. 1% ,with a drug combination rate of 45. 7% . The antibiotic use rate in surgical department was significantly higher than in department of internal medicine (68. 5% vs. 39. 2% ). The department of respiratory disease had the highest drug combination rate of 89. 6% ,followed by comprehensive ICU (85. 7% ) and the maternity department (72. 7% ). Of the top ten antibiotics on the list of DDDs,5 were cephalosporins,4 quinolones,1 aminoglycosides,1 was restrictive use category,and 1 special use category. The dosages of most cephalosporins applied were higher than DDD (defined daily dosage). The total rate of pathogens sent for etiological examination in the hospital was 55. 3% . CONCLUSIONS: The proportions of prophylactic medication and drug combination in the hospital especially in the surgical department are on the high side. The application rates of antibiotics for restrictive use or special use were also too high. The dosages of some cephalosporins were too high. Management on rational use of antimicrobial agents should be further strengthened.
Objective To observe glimepiride and acarbose treatment on 60 cases with type 2 diabetes mellitus(T2DM). Method Glimepiride and acarbose were used 12 weeks in 60 patients with T2DM. Results TG,TC, LDL-C, FBG, 2hPG and HbA1c decreased while HDL-C incressed after treatment(P <0.05); HOMA-IR was improved more significantly(P <0.05). Conclusion Glimepiride and acarbose to treat T2DM have satisfactory effects in glucose, blood lipids and HOMA-IR.
Objective To investigate the incidence of Helicobacter pylori(Hp) infection and its correlative factors in school-age children lived in Gaoyao city. Methods ELISA was adopted to examine 498 school-age children.Their parents were interviewed about correlative factors for Hp infection by questionnaire survey. Results The incidence of Hp infection was 40.91%. Multiple-factor non-conditional Logistic regression analysis showed correlative factors of Hp infection with nibbing between meal, toothcup-sharing with other family members, pet-breeders, a large population in family,low family income,crowding and parents with a history of stomach disease. Conclusion The incidence of Hp infection was higher in school-age children in Gaoyao city, health diet habits was very important to prevent Hp infection.
Objective To application of vancomycin bone cement for the treatment of patients with osteomyelitis is carried out to study the clinical effect.Methods 72 cases of patients with osteomyelitis,randomly divided into control group and treatment group,36 cases in each group on average.The conventional treatment in patients with the control group;Using vancomycin treatment bone cement for the treatment group patients.Results The treatment group patients with meningitis symptoms treatment effect is better than the control group;Symptom control time and hospitalization time significantly shorter than the control group.Conclusion Application of vancomycin bone cement for the treatment of patients with osteomyelitis implementation effect is very obvious.
Objective To explore the clinical efficacy of Laparoscopy in acute abdominal pain.Methods From 2011.3 to 2012.12,39 patients with acute abdominal pain were explored and treated by Laparoscopy in our hospital.Results All the 39 patients were unequivocally diagnosed during the operation,8 cases were appendectomy,9 cases of debridement and clysis and drainage for severe acute pancreatitis,12 cases of gastro intestinal tract perforation neoplasty,the unexplained abdominal pain 5 cases were suffered from psychological factors and functional,the 4 cases were detected by Laparoscopy and the drainage tube,gauze were extracted from the abdominal cavity.25(64%) patients were absolved from non-essential exploratory Laparotomy,38(97.4%) patients were treated by the used of Laparoscopy,1(2.6%) patients were converted to open surgery.Conclusion Emergency Laparoscopy exploration can not only clarify a diagnosis for acute abdominal pain with unknown causes,but also treat the cases simultaneously.
Objective To determine the quality standard of Litong Tea.Methods Folium sennae in Litong Tea was identified by TLC.The content Hesperidin of Pericarpium citri reticulatae was determined by HPLC.Results Folium sennae was identified by TLC;Hesperidin showed a good liner relationship at the range of 0.215-1.720μg,r=0.9997.The average recovery was 100.34%(n=6),The RSD was 1.2%.Conclusion The method is simple,accurate and exclusive with a reproducibility and can be used to control the quality of Litong Tea.
Objective To investigate CT findings of gastrointestinal stromal tumor(GIST).Methods Thirty cases of gastrointestinal stromal tumor were confirmed by surgery and pathology.The findings on CT in 30 cases were retrospectively analyzed.Conclusion Proper preparation before the CT examination to improve the detection rate,conducive to lesion localization and characterization of multislice,spiral CT scan has great value to detection and diagnosis of gastrointestinal stromal tumor.
Objective The objective of this study was to probe into the applicationvalue of the double stapling technique.Method Summary 139 patients underwent the surgical procedure of the low anterior resection were.Results These 139 cases,118 cases underwent radical excision,of which 21 cases underwent palliative excision.Postoperative follow up showed that one-year survival rate was 93.53%(130/139) and two-year survival rate was 87.77%(122/139).Anastomotic leakage in 5 cases and anastomotic stricture in 1 cases.Conclusion The procedure of low anterior resection of rectal cancer by using the double stapling technique is of many strong points,eg,simpie manipulation and less complications more successful operation.
Objective To study the clinical value of Homocysteine in the diagnosis of liver diseases.Methods March 2009-2011 in September into the hospital for treatment of liver disease in patients with 180 cases,divided into group A(control group,according to the specific sub-type of the patients with liver disease contrast group),group B1(liver cancer group),B2(hepatic cirrhosis group),B3(big three positive group),B4(small three positive group),45 cases in each group,homocysteine levels were measured in five groups of objects,and compare the measurement results.Results Homocysteine levels in All liver disease of group B was higher than the contrast group,The difference between the Each group and the contrast group had statistically significant meaning in liver diseases detection data.Conclusion The diagnosis of homocysteine levels are closely linked with liver disease,and to provide references for clinical diagnosis and treatment of liver disease with high clinical value.
This paper introduces the necessity of PACS emergency plan, and when the system crashes, staff at all levels should take the emergency plan. the purpose is to ensure that the hospital inspection departments work smooth.
Objective To summary the therapy method of huge benign prostatic hyperplasia. Method Review the clinical data of 29 patients with huge BPH who were treated by divided transurethral resection of the prostate. Of all the 29 patients, the weight of the resected prostate is 80-100g, and the average is 87g; the time of operation is 50-125 minutes, and the average is 86 minutes; only 5 patients were transfused blood after the operation. Results The IPSS decreased from 28±2.3 to 8.2±2.5; the Max of Micturition rose from 6.1±2.5ml/s to 17.6±5.4ml/s; the residual urine fell from 50-1000ml to 0-45ml. There were 4 patients had complications: 2 belong to TURS, 2 were urethral stricture. Conclusion TURP it is a safe and good method to treat huge BPH.
医学学科专业性强、内容多，对学生的基本知识要求较高，医学教育一直以来以传统的讲授为主。病理学作为研究疾病发生发展规律的基础学科，同时也是界于临床医学与基础医学之间的桥梁学科，其理论体系庞杂、涉及到的知识点涵盖范围广、内容抽象，对初学者来说难度很大。病理学实验教学多是对理论内容的复习，学生多数只能停留在对书本知识的表面理解，这使得学生丧失独立性和创造性的学习机会，不能适应当代医学生发展和求知心理的需要。
目的探讨血清可溶性转铁蛋白受体(STfR)和转铁蛋白(TRF)比值(STfR/TRF)在诊断2型糖尿病早期肾功能损伤中的价值。方法选取98例临床确诊的2型糖尿病(T2DM)患者,根据肾功能损伤程度将T2DM分为三组(糖尿病无肾损伤组、合并早期肾功能损伤组和合并晚期肾功能损伤组),选取35名健康体检者作为对照组;测定各组STfR、TRF、胱蛋白抑制素C(CysC)、血红蛋白(Hb)和红细胞压积(Hct)并进行统计学分析。采用R0C曲线分别评价STfR/TRF和CysC诊断早期肾功能损伤的价值。结果 T2DM合并早期肾功能损伤组STfR/TRF比糖尿病无肾损伤组显著升高,差异有统计学意义(P<0.01);T2DM合并晚期肾功能损伤组STfR/TRF与T2DM糖尿病无肾损伤组及早期肾功能损伤组比较差异有统计学意义(P<0.01)。STfR/TRF的ROC曲线下面积为0.818,最佳临界值取0.55时,其敏感度为78.8%,特异性为87.1%;优于胱蛋白抑制素C(曲线下面积为0.803,最佳临界值为1.00,此时敏感度为75.8%,特异性为83.9%);具有更好的敏感度和特异性。结论血清STfR/TRF可以作为2型糖尿病肾病早期诊断及反映糖尿病肾病肾功能损伤程度的敏感指标。
