Marine algae represent a valuable and still underexplored source of bioactive compounds with significant potential in dentistry. Rich in polysaccharides, polyphenols, pigments, and minerals, these organisms exhibit multiple biological activities, including antibacterial, anti-inflammatory,antioxidant, antiviral, and anticancer effects relevant to oral health. Algal-derivedcompounds such as fucoidan, carrageenan, alginate, and ulvan have demonstrated the ability to inhibit oral pathogens, modulate inflammatory responses, and support tissue regeneration. In addition, marine algae-derived biomaterials showpromising applications in several dental fields, including periodontal and bone regeneration, dental impression materials, enamel remineralization, and oral hygiene products. This review aims to highlight the biological properties of marine algae and their potential dental applications, emphasizing their role as natural and biocompatible alternatives or complementary approaches to conventional methods and materials used in modern dental practice.
Cordyceps militaris (C. militaris) is renowned for its valuable bioactive compounds, notably Cordycepin (COR) and Adenosine (ADE). However, these compounds suffer from poor stability and low bioavailability, which limit their therapeutic potential. This study successfully developed a self-assembled nano-delivery system based on a Chitosan-polyethylene glycol (PEG) matrix to encapsulate C. militaris extract. The formulation was optimized by evaluating the effects of the Chitosan/PEG mass ratio, surfactant concentration (Tween 80), and processing parameters including stirring speed and phase inversion temperature.The optimized nanoparticles achieved an ultra-small average particle size of14 ± 3.7 nm with a polydispersity index (PDI) of 0.31. High-performance liquid chromatography (HPLC) analysis confirmed high encapsulation efficiencies of72.4 % for COR and 65.2 % for ADE. Transmission Electron Microscopy (TEM) revealed that the nanoparticles possessed a spherical morphology and a uniform distribution. Stability studies indicated that the nano-system maintained its physical integrity for over 30 days. Furthermore, the encapsulated extract demonstrated significantly enhanced antibacterial activity against Staphylococcus aureus and Escherichia coli, as well as superior antioxidant capacity compared to the crude extract. These results suggest that the Chitosan-PEG nano-platform is a highly effective vehicle for improving the stability and biological performance of C. militaris bioactives in pharmaceutical and functional food applications.
A simple and sensitive spectrophotometric method is described for determination of atorvastatin calcium and valsartan in bulk and tablet forms. The method depends onthe formation of colored chromogen between atorvastatin calcium or valsartan and 1,2-naphthoquinon-4-sulphonate (NQS) and the reaction mixture exhibits maximum absorbance at lambda max 464 and 466 nm for atorvastatin calcium and valsartan, respectively. Under the indicated conditions, this method was linear over the concentration range of 2-14 & micro;g/mL and 10-120 & micro;g/mL for atorvastatin calcium and valsartan, respectively. The results were statistically processed to evaluate the method for determining the drugs in both bulk and tablet forms. Results were compared with reference methods, and no significant difference was obtained. The proposed method was validated in terms of linearity, accuracy, precision and limits of detection and quantitation according to ICH.
