【Objective】 To observe the analgesic effect of flurbiprofen axetil assisted intravenous patient-controlled analgesia（PCA） on patients undergoing orthopedic surgery. 【Methods】 Two hundred orthopedic surgery patients admitted to our hospital from February 2021 to February 2022 were selected as the research objects. The patients were divided into an observation group and a control group by lottery, with 100 cases in each group. The control group received conventional PCA after surgery. The observation group was treated with flurbiprofen axetil assisted by PCA for analgesia. The preoperative and postoperative HR, MAP and other physical indicators were compared between the two groups, and the pain conditions at different time points such as 1, 3, 5, and 7 hours after the operation were compared between the two groups, the number of PCA compressions within 72 hours after surgery,the time of stopping, the time of the first off-bed activity, hospital stay, NE, Cor, AT-Ⅱ, the occurrence of adverse events and the quality of life after surgery were compared between the two groups. 【Results】 The preoperative HR and MAP of the two groups of patients were similar（P＞0.05）; postoperatively, the HR and MAP of the observation group, the VAS score at 1, 3, 5, and 7 hours after the operation, the number of PCA compressions within 72 hours, the stop time, the time of the first off-bed activity, hospital stay, NE, Cor, and AT-II were lower than those of the control group, the incidence of adverse events of the observation group [7.00%（7/100）] was lower than that of the control group [19.00%（19/100）], and the scores of SF-36 were higher than those of the control group（P＜0.05）. 【Conclusion】 Flurbiprofen axetil assisted PCA can significantly enhance the postoperative analgesic effect of patients undergoing orthopaedic surgery, and has positive significance in reducing postoperative stress reaction, promoting physical recovery, reducing the risk of adverse events and improving the quality of life.
Mitosis is the basis of eukaryotic cell reproduction, and the mitotic orientation of cells is precisely regulated.Misorientation of mitosis often leads to aberrant development and tumorigenesis. While previous studies have focused on the exploration of molecular mechanisms, in recent years it has been found that biomechanics plays an increasingly important role in mitotic orientation. In this paper, we focus on the biomechanical progress of mitotic orientation and review both the mechanical regulatory mechanisms and the molecular structure.
Nerve growth factor（NGF） is an important trophic factor affecting nerves. It is released by target tissues to ensure functional contact between target and its innervation. NGF/TrkA signaling is a complex regulator of sensory afferents in response to injury and inflammation, and has been implicated in various pathologies such as pain, interstitial cystitis or bronchial asthma. At present, NGF/TrkA pathway is involved in the urination pathway to regulate neuronal function and participate in a variety of bladder lesions, which may represent a feasible target for the treatment of bladder dysfunction. This review aims to summarize the current experimental and clinical evidence on the role of NGF/TrkA in the bladder, so as to explore the role of NGF/TrkA signaling in bladder dysfunction diseases.
目的 探讨丁苯酞联合多奈哌齐对卒中后血管性痴呆(VD)患者认知功能、痴呆程度、血液流变学、脑微循环、血清因子的影响.方法 选取南阳市第二人民医院2020年2月至2021年9月就诊的卒中后VD患者94例,根据采取的药物治疗方案不同,分为多奈哌齐组(n=47)和丁苯酞+多奈哌齐组(n=47).对比两组治疗效果、认知功能(MMSE评分)、痴呆程度(HDS评分)、生活能力(ADL评分)、血液流变学相关指标[血浆黏度(PV)、红细胞压积(HT)、纤维蛋白原(FIB)、全血黏度(WBV)]、脑微循环指标[特性阻抗(Zc)、临界压力(CP)、脉搏速度(Wv)、动态阻力(Dr)、外周阻力(Rc)]及神经功能相关因子[神经生长因子(NGF)、低氧诱导因子-1α(HIF-1α)、雌激素(E2)、神经营养因子(BDNF)].结果 丁苯酞+多奈哌齐组总有效率(93.62％)高于多奈哌齐组(78.72％)(P＜0.05);治疗3个月后,丁苯酞+多奈哌齐组MMSE、HDS评分高于多奈哌齐组,ADL评分低于多奈哌齐组(P＜0.05);治疗3个月后,丁苯酞+多奈哌齐组PV、HT、FIB、WBV低于多奈哌齐组(P＜0.05);治疗3个月后,丁苯酞+多奈哌齐组CP高于多奈哌齐组,Zc、Wv、Dr、Rc低于多奈哌齐组(P＜0.05);治疗3个月后,丁苯酞+多奈哌齐组E2、NGF、BDNF水平高于多奈哌齐组,HIF-1α水平低于多奈哌齐组(P＜0.05).结论 丁苯酞联合多奈哌齐对卒中后VD患者的疗效显著,可提高患者的认知功能,改善患者的痴呆程度、脑血流、神经功能,调节微循环,从而提高患者的日常生活能.
【Objective】 To investigate the expression of inflammatory factors in patients with dentition defect and its relationship with the effect of oral implant repair, so as to provide guidance for the follow-up diagnosis and treatment. 【Methods】 A total of 117 patients with dentition defect who received oral implant repair treatment in the hospital from February 2019 to December 2021 were enrolled in this study by chance sampling. All patients were followed up for 1 month after the treatment, and the effects of oral implant repair were observed when the patients were followed up for 1 month. They were divided into good repair group and poor repair group. The general data and laboratory examination results of patients were investigated, and the inflammatory factors including C-reactive protein（CRP）, interleukin-6（IL-6）, human interferon γ（INF-γ） and tumor necrosis factor-α（TNF-α） were detected. The relationship between inflammatory factors and the effect of oral implant repair in patients with dentition defect was analyzed. 【Results】 Among 110 patients with dentition defect who received oral implant repair, 18 patients had poor oral implant repair, accounting for 16.36%. The levels of CRP, INF-γ, IL-6 and TNF-α in the poor repair group were higher than those in the good repair group, with a statistical significant difference（P＜0.05）. By point binary correlation test, the inflammatory factors CRP, INF-γ,IL-6 and TNF-α were positively correlated with the effect of oral implant repair in patients with dentition defect（r＞0, P＜0.05）.According to the bivariate Pearson correlation coefficient test, there was a positive correlation between CRP and TNF-α, and between IL-6 and TNF-α（r＞0, P＜0.05）. 【Conclusion】 The expression of inflammatory factors in patients with dentition defect is closely related to the effect of oral implant repair. When the level of inflammatory factors increases, it indicates that the effect of oral implant repair is poor. The effect of oral implant repair can be estimated by observing the level of inflammatory factors, and targeted treatment can be implemented in time to improve the therapeutic effect.
