Objective To compare the efficacy and safety of cryoablation(CA)and microwave ablation(MWA)for treating rabbit VX2 paravertebral tumors.Methods Forty-eight New Zealand rabbits were selected to establish models of VX2 paravertebral tumor.The rabbits were then randomly divided into CA group(n=24)and MWA group(n=24).The complete ablation rates,survival rates,Bristol rabbit pain scale(BRPS)scores and incidence of complications were compared between groups.Results The complete ablation rate and 21-day survival rate of CA group was 91.67%(22/24)and 33.33%(8/24),both better than those of MWA group(66.67%[16/24]and 16.67%[4/24]),respectively(both P＜0.05).BRPS scores of 4 h,1 day,4 days,7 days and 14 days after treatment of CA group were all lower than those of MWA group(all P＜0.001),and BRPS scores of both groups at the above time points were all lower than that before treatments(all P＜0.05).The incidence of complications in CA group(3/24,12.50%)was lower than in MWA group(8/24,33.33%)(P＜0.05).Conclusion The efficacy and safety of CA were both better than those of MWA for treating rabbit VX2 paravertebral tumors.
系统性红斑狼疮（SLE）是以多系统损害为特征的自身免疫性疾病，常累及肾脏甚至可致患者死亡。早期评估狼疮肾炎（LN）肾脏损伤对于临床治疗及预后至关重要。本文就多模态成像用于评估LN肾脏损害进展进行综述。
目的 探讨基于深度学习(DL)重建列表模式提取低剂量图像用于儿童18 F-FDG PET/CT检查的可行性.方法 对93例患儿行全身18 F-FDG PET/CT,分别以120秒/床位行标准全剂量扫描、20秒/床位行快速扫描,之后以列表模式于120秒/床位图像中提取20秒/床位图像.将20秒/床位图像与以列表模式提取的20秒/床位图像传输至DL平台进行重建,分别获得相应全剂量图像(DL-f20s、DL-20s);对比标准全剂量120s、DL-f20s、DL-20s图像的靶本比(TBR)、对比噪声比(CNR)、变异系数(CV)、图像质量主观评分,以及肝血池、纵隔血池、肌肉血池及原发病灶最大标准摄取值(SUVmax)和平均标准摄取值(SUVmean),分析基于DL-f20s与DL-20s图像所获SUVmax及SUVmean的一致性.结果 120s、DL-f20s和DL-20s图像的主观质量Likert评分、TBR、CNR、CV及各血池、病灶的SUVmax、SUVmean差异均无统计学意义(P均>0.05).DL-f20s与DL-20s图像之间,5％以上肌肉血池SUVmax、SUVmean差值在95％一致性界限(LoA)以外,其余血池及病灶的SUVmax、SUVmean差值在95％LoA以外者均≤5％.结论 基于DL重建列表模式提取低剂量图像可用于儿童18 F-FDG PET/CT检查,且所获图像的质量及代谢参数与快速扫描相当.
Objective To observe the risk factors of recurrence after ultrasound-guided thermal ablation for treating uremia secondary hyperparathyroidism(SHPT).Methods Totally 59 patients with uremia SHPT who underwent ultrasound-guided thermal ablation were enrolled,including 23 cases with(relapse group)and 36 without SHPT recurrence(non relapsed group).Clinical data were compared between groups,univariate and multivariate logistic regression analysis were performed to screen independent risk factors of SHPT recurrence.Results There were significant differences of serum free thyroxine(FT4),urea,intact parathyroid hormone(iPTH)1 day after ablation,1 day decrease rate of iPTH,the maximum diameter of the largest nodule,ablation time,total ablation energy,energy to volume ratio and the proportion of 1 day decrease rate of iPTH≤90%between groups(all P＜0.05).Higher urea,lower energy to volume ratio and 1 day decrease rate of iPTH≤90%were all independent risk factors of SHPT recurrence(all P＜0.05).Conclusion Higher urea,lower energy to volume ratio and 1 day decrease rate of iPTH≤90%were independent risk factors of recurrence after ultrasound-guided thermal ablation for treating uremia SHPT.
希氏-浦肯野系统起搏为生理性心室起搏方式,包括希氏束起搏(His' bundle pacing, HBP)及左束支(left bundle branch, LBB)起 搏(left bundle branch pacing, LBBP),理论上可恢复心肌收缩同步性、改善心脏功能[1-2].相比HBP,LBBP具有起搏阈值低、可跳过希氏束及以下传导阻滞处和操作难度低等优势[3],其成功关键在于准确定位左束支;目前临床常以多导电生理仪定位左束支.本研究报道以临时起搏电极辅助定位19例患者LBB行LBBP的效果.
