Структурно-функциональные Взаимосвязи В Почках Крыс С Гентамициновой Нефропатией

The close interrelation has been established between the renal functional and structural indices in rats having gentamicin-induced nephropathy (60 mg/kg, intraperitoneally, once a day х 10). The positive interconnection between the increased plasma concentration of middle molecules, urea, creatinine and the percentage of severely damaged and lost proximal convoluted tubules (PCT) cortical nephrons (CN)) has been marked. The negative interconnection was found for the urea and the creatinine in the urine. Therefore, it is possible to predict the character and degree of the destruction of PCK CN on the basis of the results of plasma and urine examinations.